C5J411 (XYNC_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable endo-1,4-beta-xylanase C
Short name=Xylanase C
EC=3.2.1.8

Alternative name(s):
1,4-beta-D-xylan xylanohydrolase C

Gene names

Name:

xlnC

Organism

Aspergillus niger

Taxonomic identifier

5061 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose By similarity.
Catalytic activity	Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
Pathway	Glycan degradation; xylan degradation.
Subcellular location	Secreted By similarity.
Induction	Expressed in presence of xylan and repressed by glucose.
Sequence similarities	Belongs to the glycosyl hydrolase 10 (cellulase F) family.

Ontologies

Keywords
Biological process	Xylan degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	xylan catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular region Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	endo-1,4-beta-xylanase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 327	308	Probable endo-1,4-beta-xylanase C		PRO_0000393190
Sites
	Active site	157	1	Proton donor By similarity
	Active site	263	1	Nucleophile By similarity
Amino acid modifications
	Disulfide bond	281 ↔ 287		By similarity
Experimental info
	Sequence conflict	11 – 13	3	MLF → KLI in ACR83565. Ref.1
	Sequence conflict	23	1	D → E in ACR83565. Ref.1
	Sequence conflict	77	1	W → R in ACR83565. Ref.1
	Sequence conflict	123	1	S → A in ACR83565. Ref.1
	Sequence conflict	132	1	E → G in ACR83565. Ref.1
	Sequence conflict	208	1	S → P in ACR83565. Ref.1
	Sequence conflict	268	1	G → D in ACR83565. Ref.1
	Sequence conflict	283	1	N → D in ACR83565. Ref.1
	Sequence conflict	321 – 323	3	DAI → FAV in ACR83565. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	C5J411 [UniParc]. Last modified March 23, 2010. Version 2. Checksum: 90B2F71FFCA70A65	FASTA	327	35,476
	10 20 30 40 50 60 MVQIKVAALA MLFASQVLSE PIDPRQASVS IDTKFKAHGK KYLGNIGDQY TLTKNSKTPA 70 80 90 100 110 120 IIKADFGALT PENSMKWDAT EPSRGQFSFS GSDYLVNFAQ SNNKLIRGHT LVWHSQLPSW 130 140 150 160 170 180 VQSITDKNTL IEVMKNHITT VMQHYKGKIY AWDVVNEIFN EDGSLRDSVF YKVIGEDYVR 190 200 210 220 230 240 IAFETARAAD PNAKLYINDY NLDSASYSKL TGMVSHVKKW IAAGIPIDGI GSQTHLSAGG 250 260 270 280 290 300 GAGISGALNA LAGAGTKEIA VTELDIAGAS STDYVEVVEA CLNQPKCIGI TVWGVADPDS 310 320 WRSSSTPLLF DSNYNPKPAY DAIANAL

References

[1]	"Gene cloning, sequencing, expression and characterization of a xylanase A gene from Aspergillus niger DMS1957." Nguyen S.L.T., Quyen D.T. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DMS1957.
[2]	Huang J.Z., Xu Y., Tian B.Y., Huang Q.G. Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: IME-216.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FJ986225 mRNA. Translation: ACR83565.1. EU848304 mRNA. Translation: ACJ26381.1.
3D structure databases
ProteinModelPortal	C5J411.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG3693.
Enzyme and pathway databases
UniPathway	UPA00114.
Family and domain databases
Gene3D	3.20.20.80. 1 hit.
InterPro	IPR001000. Glyco_hydro_10. IPR013781. Glyco_hydro_catalytic_dom. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF00331. Glyco_hydro_10. 1 hit. [Graphical view]
PRINTS	PR00134. GLHYDRLASE10.
SMART	SM00633. Glyco_10. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00591. GLYCOSYL_HYDROL_F10. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYNC_ASPNG

Accession

Primary (citable) accession number: C5J411
Secondary accession number(s): C6F1T1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 23, 2010
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 21 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program