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Protein
Submitted name:

Amiloride-sensitive sodium channel subunit alpha 1

Gene

SCNN1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Sodium channelSAAS annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Submitted name:
Amiloride-sensitive sodium channel subunit alpha 1Imported
Gene namesi
Name:SCNN1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei144 – 165HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiC5HTY8.

Family & Domainsi

Sequence similaritiesi

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
HOGENOMiHOG000236286.

Family and domain databases

InterProiView protein in InterPro
IPR001873. ENaC.
IPR004724. ENaC_chordates.
IPR020903. ENaC_CS.
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiView protein in Pfam
PF00858. ASC. 1 hit.
PRINTSiPR01078. AMINACHANNEL.
TIGRFAMsiTIGR00859. ENaC. 1 hit.
PROSITEiView protein in PROSITE
PS01206. ASC. 1 hit.

Sequencei

Sequence statusi: Complete.

C5HTY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMARGSLTR VPGVMGEGTQ GPELSLDPDP CSPQSTPGLM KGNKLEEQDP
60 70 80 90 100
RPLQPIPGLM EGNKLEEQDS SPPQSTPGLM KGNKREEQGL GPEPAAPQQP
110 120 130 140 150
TAEEEALIEF HRSYRELFEF FCNNTTIHGA IRLVCSQHNR MKTAFWAVLW
160 170 180 190 200
LCTFGMMYWQ FGLLFGEYFS YPVSLNINLN SDKLVFPAVT ICTLNPYRYP
210 220 230 240 250
EIKEELEELD RITEQTLFDL YKYSSFTTLV AGSRSRRDLR GTLPHPLQRL
260 270 280 290 300
RVPPPPHGAR RARSVASSLR DNNPQVDWKD WKIGFQLCNQ NKSDCFYQTY
310 320 330 340 350
SSGVDAVREW YRFHYINILS RLPETLPSLE EDTLGNFIFA CRFNQVSCNQ
360 370 380 390 400
ANYSHFHHPM YGNCYTFNDK NNSNLWMSSM PGINNGLSLM LRAEQNDFIP
410 420 430 440 450
LLSTVTGARV MVHGQDEPAF MDDGGFNLRP GGEASRRGWQ ETLDRLGGDY
460 470 480 490 500
GDCTKNGSDV PVENLYPSKY TQQVCIHSCF QESMIKECGC AYIFYPRPQN
510 520 530 540 550
VEYCDYRKHS SWGYCYYKLQ VDFSSDHLGC FTKCRKPCSV TSYQLSAGYS
560 570 580 590 600
RWPSVTSQEW VFQMLSRQNN YTVNNKRNGV AKVNIFFKEL NYKTNSESPS
610 620 630 640 650
VTMVTLLSNL GSQWSLWFGS SVLSVVEMAE LVFDLLVIMF LMLLRRFRSR
660 670 680 690 700
YWSPGRGGRG AQEVASTLAS SPPSHFCPHP MSLSLSQPGP APSPALTAPP
710 720
PAYATLGPRP SPGGSAGASS STCPLGGP
Length:728
Mass (Da):81,852
Last modified:July 28, 2009 - v1
Checksum:i0234FF9B64B096ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ515830 Genomic DNA. Translation: ACS13720.1.
UniGeneiHs.591047.

Similar proteinsi

Entry informationi

Entry nameiC5HTY8_HUMAN
AccessioniPrimary (citable) accession number: C5HTY8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 27, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.