ID   C5H8V4_MOUSE            Unreviewed;        70 AA.
AC   C5H8V4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
DE   Flags: Fragment;
GN   Name=Slc40a1 {ECO:0000313|EMBL:ACO54854.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000140549.2,
GN   ECO:0000313|MGI:MGI:1315204};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:ACO54854.1};
RN   [1] {ECO:0000313|EMBL:ACO54854.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c {ECO:0000313|EMBL:ACO54854.1};
RC   TISSUE=Spleen {ECO:0000313|EMBL:ACO54854.1};
RA   Zhang D.-L., Rouault T.A.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACO54854.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c {ECO:0000313|EMBL:ACO54854.1};
RC   TISSUE=Spleen {ECO:0000313|EMBL:ACO54854.1};
RX   PubMed=19416716; DOI=10.1016/j.cmet.2009.03.006;
RA   Zhang D.L., Hughes R.M., Ollivierre-Wilson H., Ghosh M.C., Rouault T.A.;
RT   "A ferroportin transcript that lacks an iron-responsive element enables
RT   duodenal and erythroid precursor cells to evade translational repression.";
RL   Cell Metab. 9:461-473(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000140549.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140549.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000140549.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140549.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC       {ECO:0000256|RuleBase:RU365065}.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU365065}.
CC   -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC       subfamily. {ECO:0000256|RuleBase:RU365065}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR   EMBL; FJ207421; ACO54854.1; -; mRNA.
DR   EMBL; FJ207422; ACO54855.1; -; mRNA.
DR   EMBL; FJ207423; ACO54856.1; -; mRNA.
DR   ProteomicsDB; 308446; -.
DR   Antibodypedia; 34022; 443 antibodies from 33 providers.
DR   Ensembl; ENSMUST00000186804.2; ENSMUSP00000140969.2; ENSMUSG00000025993.11.
DR   Ensembl; ENSMUST00000187406.7; ENSMUSP00000140734.2; ENSMUSG00000025993.11.
DR   Ensembl; ENSMUST00000187420.7; ENSMUSP00000140549.2; ENSMUSG00000025993.11.
DR   UCSC; uc011wkh.1; mouse.
DR   AGR; MGI:1315204; -.
DR   MGI; MGI:1315204; Slc40a1.
DR   VEuPathDB; HostDB:ENSMUSG00000025993; -.
DR   GeneTree; ENSGT00390000015143; -.
DR   HOGENOM; CLU_203554_0_0_1; -.
DR   OMA; NIGNWVD; -.
DR   ChiTaRS; Slc40a1; mouse.
DR   Proteomes; UP000000589; Chromosome 1.
DR   Bgee; ENSMUSG00000025993; Expressed in epithelium of small intestine and 240 other cell types or tissues.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR009716; Ferroportin-1.
DR   PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR   PANTHER; PTHR11660:SF47; SOLUTE CARRIER FAMILY 40 MEMBER 1; 1.
DR   Pfam; PF06963; FPN1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|RuleBase:RU365065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:C5H8V4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT   TRANSMEM        41..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   NON_TER         70
FT                   /evidence="ECO:0000313|EMBL:ACO54854.1"
SQ   SEQUENCE   70 AA;  7713 MW;  F933CD44683CD4EE CRC64;
     MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL
     TAVYGLVVAG
//