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C5H3H4

- C5H3H4_MOUSE

UniProt

C5H3H4 - C5H3H4_MOUSE

Protein
Submitted name:

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. induction of positive chemotaxis Source: MGI
    2. inflammatory response Source: MGI

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_198647. Advanced glycosylation endproduct receptor signaling.
    REACT_202898. TRAF6 mediated NF-kB activation.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_222971. RIP-mediated NFkB activation via ZBP1.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Advanced glycosylation end product-specific receptorImported
    Submitted name:
    Advanced glycosylation end products receptor splice variant 1Imported
    Submitted name:
    Advanced glycosylation end products receptor splice variant 3Imported
    Gene namesi
    Name:AgerImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:893592. Ager.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriC5H3H4.

    Family & Domainsi

    Keywords - Domaini

    Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000111389.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5H3H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE    50
    WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA 100
    TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP 150
    AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT 200
    HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG 250
    GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV 300
    ATHPSHGPQE SPPVSIRVTE TGDEGPAEGE GLD 333
    Length:333
    Mass (Da):35,362
    Last modified:July 28, 2009 - v1
    Checksum:i7AC9E992F2DDF3F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT009767 Genomic DNA. No translation available.
    EU570240 mRNA. Translation: ACE63492.1.
    EU570242 mRNA. Translation: ACE63494.1.
    UniGeneiMm.3383.

    Genome annotation databases

    EnsembliENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452.
    UCSCiuc008ccw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT009767 Genomic DNA. No translation available.
    EU570240 mRNA. Translation: ACE63492.1 .
    EU570242 mRNA. Translation: ACE63494.1 .
    UniGenei Mm.3383.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000174069 ; ENSMUSP00000133391 ; ENSMUSG00000015452 .
    UCSCi uc008ccw.2. mouse.

    Organism-specific databases

    MGIi MGI:893592. Ager.

    Phylogenomic databases

    GeneTreei ENSGT00730000111389.

    Enzyme and pathway databases

    Reactomei REACT_198647. Advanced glycosylation endproduct receptor signaling.
    REACT_202898. TRAF6 mediated NF-kB activation.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_222971. RIP-mediated NFkB activation via ZBP1.

    Miscellaneous databases

    NextBioi 35548206.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori C5H3H4.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene."
      Kalea A.Z., Reiniger N., Yang H., Arriero M., Schmidt A.M., Hudson B.I.
      FASEB J. 23:1766-1774(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/cImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiC5H3H4_MOUSE
    AccessioniPrimary (citable) accession number: C5H3H4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3