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C5H3H4

- C5H3H4_MOUSE

UniProt

C5H3H4 - C5H3H4_MOUSE

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Protein
Submitted name:

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. induction of positive chemotaxis Source: MGI
  2. inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_198647. Advanced glycosylation endproduct receptor signaling.
REACT_202898. TRAF6 mediated NF-kB activation.
REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_222971. RIP-mediated NFkB activation via ZBP1.

Names & Taxonomyi

Protein namesi
Submitted name:
Advanced glycosylation end product-specific receptorImported
Submitted name:
Advanced glycosylation end products receptor splice variant 1Imported
Submitted name:
Advanced glycosylation end products receptor splice variant 3Imported
Gene namesi
Name:AgerImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:893592. Ager.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriC5H3H4.

Family & Domainsi

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063457.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5H3H4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA
110 120 130 140 150
TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP
160 170 180 190 200
AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT
210 220 230 240 250
HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG
260 270 280 290 300
GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV
310 320 330
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGE GLD
Length:333
Mass (Da):35,362
Last modified:July 28, 2009 - v1
Checksum:i7AC9E992F2DDF3F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT009767 Genomic DNA. No translation available.
EU570240 mRNA. Translation: ACE63492.1.
EU570242 mRNA. Translation: ACE63494.1.
UniGeneiMm.3383.

Genome annotation databases

EnsembliENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452.
UCSCiuc008ccw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT009767 Genomic DNA. No translation available.
EU570240 mRNA. Translation: ACE63492.1 .
EU570242 mRNA. Translation: ACE63494.1 .
UniGenei Mm.3383.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000174069 ; ENSMUSP00000133391 ; ENSMUSG00000015452 .
UCSCi uc008ccw.2. mouse.

Organism-specific databases

MGIi MGI:893592. Ager.

Phylogenomic databases

GeneTreei ENSGT00530000063457.

Enzyme and pathway databases

Reactomei REACT_198647. Advanced glycosylation endproduct receptor signaling.
REACT_202898. TRAF6 mediated NF-kB activation.
REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_222971. RIP-mediated NFkB activation via ZBP1.

Miscellaneous databases

NextBioi 35548206.
SOURCEi Search...

Gene expression databases

Genevestigatori C5H3H4.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene."
    Kalea A.Z., Reiniger N., Yang H., Arriero M., Schmidt A.M., Hudson B.I.
    FASEB J. 23:1766-1774(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiC5H3H4_MOUSE
AccessioniPrimary (citable) accession number: C5H3H4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3