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Protein
Submitted name:

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • advanced glycation end-product binding Source: MGI
  • heparin binding Source: MGI
  • identical protein binding Source: MGI
  • S100 protein binding Source: MGI

GO - Biological processi

  • astrocyte development Source: MGI
  • induction of positive chemotaxis Source: MGI
  • inflammatory response Source: MGI
  • negative regulation of advanced glycation end-product receptor activity Source: MGI
  • negative regulation of connective tissue replacement involved in inflammatory response wound healing Source: MGI
  • neuron projection development Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of JUN kinase activity Source: MGI
  • positive regulation of monocyte chemotactic protein-1 production Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • protein localization to membrane Source: MGI
  • regulation of DNA binding Source: MGI
  • response to hypoxia Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-MMU-1810476. RIP-mediated NFkB activation via ZBP1.
R-MMU-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-879415. Advanced glycosylation endproduct receptor signaling.
R-MMU-933542. TRAF6 mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Submitted name:
Advanced glycosylation end product-specific receptorImported
Submitted name:
Advanced glycosylation end products receptor splice variant 1Imported
Submitted name:
Advanced glycosylation end products receptor splice variant 3Imported
Gene namesi
Name:AgerImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:893592. Ager.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 333311Sequence analysisPRO_5005906589Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 109108Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini123 – 21997Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini233 – 31583Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
GeneTreeiENSGT00530000063457.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5H3H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA
110 120 130 140 150
TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP
160 170 180 190 200
AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT
210 220 230 240 250
HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG
260 270 280 290 300
GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV
310 320 330
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGE GLD
Length:333
Mass (Da):35,362
Last modified:July 28, 2009 - v1
Checksum:i7AC9E992F2DDF3F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009767 Genomic DNA. No translation available.
EU570240 mRNA. Translation: ACE63492.1.
EU570242 mRNA. Translation: ACE63494.1.
UniGeneiMm.3383.

Genome annotation databases

EnsembliENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452.
UCSCiuc008ccw.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009767 Genomic DNA. No translation available.
EU570240 mRNA. Translation: ACE63492.1.
EU570242 mRNA. Translation: ACE63494.1.
UniGeneiMm.3383.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452.
UCSCiuc008ccw.3. mouse.

Organism-specific databases

MGIiMGI:893592. Ager.

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
GeneTreeiENSGT00530000063457.

Enzyme and pathway databases

ReactomeiR-MMU-1810476. RIP-mediated NFkB activation via ZBP1.
R-MMU-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-879415. Advanced glycosylation endproduct receptor signaling.
R-MMU-933542. TRAF6 mediated NF-kB activation.

Miscellaneous databases

NextBioi35548206.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene."
    Kalea A.Z., Reiniger N., Yang H., Arriero M., Schmidt A.M., Hudson B.I.
    FASEB J. 23:1766-1774(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiC5H3H4_MOUSE
AccessioniPrimary (citable) accession number: C5H3H4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: January 20, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.