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Protein
Submitted name:

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. identical protein binding Source: MGI
  2. S100 protein binding Source: MGI

GO - Biological processi

  1. induction of positive chemotaxis Source: MGI
  2. inflammatory response Source: MGI
  3. neuron projection development Source: MGI
  4. positive regulation of JUN kinase activity Source: MGI
  5. positive regulation of NF-kappaB transcription factor activity Source: MGI
  6. protein localization to membrane Source: MGI
  7. regulation of DNA binding Source: MGI
  8. response to hypoxia Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_275137. TRAF6 mediated NF-kB activation.
REACT_283225. RIP-mediated NFkB activation via ZBP1.
REACT_305279. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_342554. Advanced glycosylation endproduct receptor signaling.
REACT_343658. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.

Names & Taxonomyi

Protein namesi
Submitted name:
Advanced glycosylation end product-specific receptorImported
Submitted name:
Advanced glycosylation end products receptor splice variant 1Imported
Submitted name:
Advanced glycosylation end products receptor splice variant 3Imported
Gene namesi
Name:AgerImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:893592. Ager.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiC5H3H4.
ExpressionAtlasiC5H3H4. baseline and differential.
GenevestigatoriC5H3H4.

Structurei

3D structure databases

ProteinModelPortaliC5H3H4.
SMRiC5H3H4. Positions 21-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00770000120702.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5H3H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA
110 120 130 140 150
TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP
160 170 180 190 200
AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT
210 220 230 240 250
HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG
260 270 280 290 300
GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV
310 320 330
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGE GLD
Length:333
Mass (Da):35,362
Last modified:July 28, 2009 - v1
Checksum:i7AC9E992F2DDF3F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009767 Genomic DNA. No translation available.
EU570240 mRNA. Translation: ACE63492.1.
EU570242 mRNA. Translation: ACE63494.1.
UniGeneiMm.3383.

Genome annotation databases

EnsembliENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452.
UCSCiuc008ccw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009767 Genomic DNA. No translation available.
EU570240 mRNA. Translation: ACE63492.1.
EU570242 mRNA. Translation: ACE63494.1.
UniGeneiMm.3383.

3D structure databases

ProteinModelPortaliC5H3H4.
SMRiC5H3H4. Positions 21-318.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452.
UCSCiuc008ccw.2. mouse.

Organism-specific databases

MGIiMGI:893592. Ager.

Phylogenomic databases

GeneTreeiENSGT00770000120702.

Enzyme and pathway databases

ReactomeiREACT_275137. TRAF6 mediated NF-kB activation.
REACT_283225. RIP-mediated NFkB activation via ZBP1.
REACT_305279. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_342554. Advanced glycosylation endproduct receptor signaling.
REACT_343658. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.

Miscellaneous databases

NextBioi35548206.
SOURCEiSearch...

Gene expression databases

BgeeiC5H3H4.
ExpressionAtlasiC5H3H4. baseline and differential.
GenevestigatoriC5H3H4.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene."
    Kalea A.Z., Reiniger N., Yang H., Arriero M., Schmidt A.M., Hudson B.I.
    FASEB J. 23:1766-1774(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (AUG-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiC5H3H4_MOUSE
AccessioniPrimary (citable) accession number: C5H3H4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.