C5GXZ9 (AMPP1_AJEDR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	BDCG_09239

Organism

Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis) [Complete proteome]

Taxonomic identifier

559297 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces › Ajellomyces dermatitidis

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 617	617	Probable Xaa-Pro aminopeptidase P		PRO_0000411773
Sites
	Metal binding	414	1	Manganese 2 By similarity
	Metal binding	425	1	Manganese 1 By similarity
	Metal binding	425	1	Manganese 2 By similarity
	Metal binding	523	1	Manganese 1 By similarity
	Metal binding	537	1	Manganese 1 By similarity
	Metal binding	537	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5GXZ9 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: FCE8AE5E32AF2D65	FASTA	617	68,559
	10 20 30 40 50 60 MGPVDTSQRL ARLRELMQER KVDVYIVPSE DSHQSEYIAP CDGRREFISG FTGSAGCAIV 70 80 90 100 110 120 SMSKAALSTD GRYFNQAAKQ LDNNWMLLKR GFENMPTWQE WTAEQAEGGK VVGVDPSLIT 130 140 150 160 170 180 ASEARSLSET IEKSGGSLQG VQENLIDLVW GKERPARPSE KVALHPIEFA GKSFEEKISD 190 200 210 220 230 240 LRKELQKKKS AGFVISMLDE IAWLFNLRGN DIPYNPVFFA YAIITPTTAD LYIDDEKLPA 250 260 270 280 290 300 EVKKYLGDQV SVKPYGSIFE DAKALSQSAQ KKSDGDASTS PSEKFLISTK ASWSLSLALG 310 320 330 340 350 360 GEKNVEEVRS PITDAKAIKN EAELEGMRAC HIRDGAALTE YFAWLENELV NKKTVLNEVD 370 380 390 400 410 420 GSDKLEQIRS KHKHFVGLSF DTISSTGPNA AVIHYKAERD TCSIIDPKAV YLCDSGAQYL 430 440 450 460 470 480 DGTTDTTRTL HFGEPTEMER KAYTLVLKGL ISIDTAVFPK GTTGFALDAF ARQHLWKEGL 490 500 510 520 530 540 DYLHGTGHGV GSYLNVHEGP IGLGTRVQYA EVAITPGNVI SDEPGFYEDG VFGIRIENII 550 560 570 580 590 600 IAKEVKTTHG FGEKPWLGFE HVTMTPLCQK LINPSLLTDG EKKWVNDYHS KVWEKTSSYF 610 ENDELTRNWL KRETQPI

References

[1]

"The genome sequence of Blastomyces dermatitidis strain ER-3." Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S. , Galagan J.E., Nusbaum C., Birren B.W. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ER-3 / ATCC MYA-2586.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EQ999986 Genomic DNA. Translation: EEQ85970.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M24.009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
OrthoDB	EOG45F0XX.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_AJEDR

Accession

Primary (citable) accession number: C5GXZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 28, 2009
Last modified:	March 6, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program