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C5GVF3 (DAPB_AJEDR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:BDCG_08583
OrganismAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis) [Complete proteome]
Taxonomic identifier559297 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Protein attributes

Sequence length915 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 915915Probable dipeptidyl-aminopeptidase B
PRO_0000412127

Regions

Topological domain1 – 9595Cytoplasmic Potential
Transmembrane96 – 11621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain117 – 915799Vacuolar Potential

Sites

Active site7541Charge relay system By similarity
Active site8311Charge relay system By similarity
Active site8641Charge relay system By similarity

Amino acid modifications

Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation5721N-linked (GlcNAc...) Potential
Glycosylation8131N-linked (GlcNAc...) Potential
Glycosylation9001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5GVF3 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 396FF2E496FA8454

FASTA915102,912
        10         20         30         40         50         60 
MAGEKGGSRD EEREPLTRGS IEFRDSINSF DYSSSTASLS LAVIDRINGS TQDSRLGEKD 

        70         80         90        100        110        120 
QRDDDHDQYR NEEEYDVEDA DYIPSGGKTV QKTTKIVLWA LLFLCVGGWS LAFVIFLFRG 

       130        140        150        160        170        180 
HDTPQTSIAS EENISSGGAR GNRITLDEVL GGEWAPRAHS ISWFPGPNGE DGLILEKDNL 

       190        200        210        220        230        240 
SATAYLRVED IVGRKDPKAS KKSIVLMQKK MFTVGRETVY SAQAWPSPDL KTVLVLSDQQ 

       250        260        270        280        290        300 
KNWRHSFTGK YWLFDVETQT GQPLDPGAPD RRIQLASWSP QSDAVVFTRD NNMFLRKLTS 

       310        320        330        340        350        360 
NEVATITTDG GVDLFYGVPD WVYEEEVFSG NSATWWASDG DYIAFLRTNE SSVPDYPIQY 

       370        380        390        400        410        420 
FASRPSGENP KPGEENYPEV REVKYPKAGA PNPIVDLQFY DVGKGEVFSV DVTSEFADDD 

       430        440        450        460        470        480 
RLIIEVLWAS NGKALVRETN RESDILSIAI IDVLSRTGRI VRREDVNALD GGWVEPTQST 

       490        500        510        520        530        540 
RFIPADPDHG RLDDGYIDTV IYEGRDQLAY FTPLDNPKPI MLTKGHSEVV NAPSGVDLKR 

       550        560        570        580        590        600 
GLVYFVVAGN EPWERHIYSV NFDGTSLQPL TNVTESSYYD VSFSNGAGYA LLNYRGPKVP 

       610        620        630        640        650        660 
WQKVINTPAN ENSFEAIIEQ NDHLSRKLRL FSLESKVYQH VTVDGFSLPV MERRPPNFDP 

       670        680        690        700        710        720 
AKKYPVLFHL YGGPGSQTVS KKFSVDFQSY VASTLGYIVV TVDGRGTGHI GRKARCIIRG 

       730        740        750        760        770        780 
NLGHYEARDQ IETAKKWAAK PYVDESRMAI WGWSYGGFMT LKTLEQDGGR TFQYGMAVAP 

       790        800        810        820        830        840 
VTDWRYYDSI YTERYMRTPQ HNQGGYDTSA ISNTTALASN IRFLLMHGTA DDNVHIQNSL 

       850        860        870        880        890        900 
TLLDKLDLDD VDNYDVHVFP DSDHSIYFHN AHKMVYNRLG DWLINAFNGE WLKVHKPTPN 

       910 
NSLFRRAETW GGLPV 

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References

[1]"The genome sequence of Blastomyces dermatitidis strain ER-3."
Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S. expand/collapse author list , Galagan J.E., Nusbaum C., Birren B.W.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ER-3 / ATCC MYA-2586.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ999983 Genomic DNA. Translation: EEQ85314.1.

3D structure databases

ProteinModelPortalC5GVF3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_AJEDR
AccessionPrimary (citable) accession number: C5GVF3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries