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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay systemBy similarity
Active sitei831 – 8311Charge relay systemBy similarity
Active sitei864 – 8641Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:BDCG_08583
OrganismiAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Taxonomic identifieri559297 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeBlastomyces
ProteomesiUP000002039 Componenti: Unassembled WGS sequence

Subcellular locationi

  1. Vacuole membrane By similarity; Single-pass type II membrane protein By similarity

  2. Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei96 – 11621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini117 – 915799VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915Probable dipeptidyl-aminopeptidase BPRO_0000412127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi900 – 9001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC5GVF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C5GVF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKGGSRD EEREPLTRGS IEFRDSINSF DYSSSTASLS LAVIDRINGS
60 70 80 90 100
TQDSRLGEKD QRDDDHDQYR NEEEYDVEDA DYIPSGGKTV QKTTKIVLWA
110 120 130 140 150
LLFLCVGGWS LAFVIFLFRG HDTPQTSIAS EENISSGGAR GNRITLDEVL
160 170 180 190 200
GGEWAPRAHS ISWFPGPNGE DGLILEKDNL SATAYLRVED IVGRKDPKAS
210 220 230 240 250
KKSIVLMQKK MFTVGRETVY SAQAWPSPDL KTVLVLSDQQ KNWRHSFTGK
260 270 280 290 300
YWLFDVETQT GQPLDPGAPD RRIQLASWSP QSDAVVFTRD NNMFLRKLTS
310 320 330 340 350
NEVATITTDG GVDLFYGVPD WVYEEEVFSG NSATWWASDG DYIAFLRTNE
360 370 380 390 400
SSVPDYPIQY FASRPSGENP KPGEENYPEV REVKYPKAGA PNPIVDLQFY
410 420 430 440 450
DVGKGEVFSV DVTSEFADDD RLIIEVLWAS NGKALVRETN RESDILSIAI
460 470 480 490 500
IDVLSRTGRI VRREDVNALD GGWVEPTQST RFIPADPDHG RLDDGYIDTV
510 520 530 540 550
IYEGRDQLAY FTPLDNPKPI MLTKGHSEVV NAPSGVDLKR GLVYFVVAGN
560 570 580 590 600
EPWERHIYSV NFDGTSLQPL TNVTESSYYD VSFSNGAGYA LLNYRGPKVP
610 620 630 640 650
WQKVINTPAN ENSFEAIIEQ NDHLSRKLRL FSLESKVYQH VTVDGFSLPV
660 670 680 690 700
MERRPPNFDP AKKYPVLFHL YGGPGSQTVS KKFSVDFQSY VASTLGYIVV
710 720 730 740 750
TVDGRGTGHI GRKARCIIRG NLGHYEARDQ IETAKKWAAK PYVDESRMAI
760 770 780 790 800
WGWSYGGFMT LKTLEQDGGR TFQYGMAVAP VTDWRYYDSI YTERYMRTPQ
810 820 830 840 850
HNQGGYDTSA ISNTTALASN IRFLLMHGTA DDNVHIQNSL TLLDKLDLDD
860 870 880 890 900
VDNYDVHVFP DSDHSIYFHN AHKMVYNRLG DWLINAFNGE WLKVHKPTPN
910
NSLFRRAETW GGLPV
Length:915
Mass (Da):102,912
Last modified:July 28, 2009 - v1
Checksum:i396FF2E496FA8454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ999983 Genomic DNA. Translation: EEQ85314.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ999983 Genomic DNA. Translation: EEQ85314.1.

3D structure databases

ProteinModelPortaliC5GVF3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Blastomyces dermatitidis strain ER-3."
    Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
    , Galagan J.E., Nusbaum C., Birren B.W.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ER-3 / ATCC MYA-2586.

Entry informationi

Entry nameiDAPB_AJEDR
AccessioniPrimary (citable) accession number: C5GVF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: February 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.