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C5GVF3

- DAPB_AJEDR

UniProt

C5GVF3 - DAPB_AJEDR

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei754 – 7541Charge relay systemBy similarity
    Active sitei831 – 8311Charge relay systemBy similarity
    Active sitei864 – 8641Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:BDCG_08583
    OrganismiAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
    Taxonomic identifieri559297 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000002039: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 915915Probable dipeptidyl-aminopeptidase BPRO_0000412127Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi900 – 9001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliC5GVF3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini117 – 915799VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5GVF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGEKGGSRD EEREPLTRGS IEFRDSINSF DYSSSTASLS LAVIDRINGS    50
    TQDSRLGEKD QRDDDHDQYR NEEEYDVEDA DYIPSGGKTV QKTTKIVLWA 100
    LLFLCVGGWS LAFVIFLFRG HDTPQTSIAS EENISSGGAR GNRITLDEVL 150
    GGEWAPRAHS ISWFPGPNGE DGLILEKDNL SATAYLRVED IVGRKDPKAS 200
    KKSIVLMQKK MFTVGRETVY SAQAWPSPDL KTVLVLSDQQ KNWRHSFTGK 250
    YWLFDVETQT GQPLDPGAPD RRIQLASWSP QSDAVVFTRD NNMFLRKLTS 300
    NEVATITTDG GVDLFYGVPD WVYEEEVFSG NSATWWASDG DYIAFLRTNE 350
    SSVPDYPIQY FASRPSGENP KPGEENYPEV REVKYPKAGA PNPIVDLQFY 400
    DVGKGEVFSV DVTSEFADDD RLIIEVLWAS NGKALVRETN RESDILSIAI 450
    IDVLSRTGRI VRREDVNALD GGWVEPTQST RFIPADPDHG RLDDGYIDTV 500
    IYEGRDQLAY FTPLDNPKPI MLTKGHSEVV NAPSGVDLKR GLVYFVVAGN 550
    EPWERHIYSV NFDGTSLQPL TNVTESSYYD VSFSNGAGYA LLNYRGPKVP 600
    WQKVINTPAN ENSFEAIIEQ NDHLSRKLRL FSLESKVYQH VTVDGFSLPV 650
    MERRPPNFDP AKKYPVLFHL YGGPGSQTVS KKFSVDFQSY VASTLGYIVV 700
    TVDGRGTGHI GRKARCIIRG NLGHYEARDQ IETAKKWAAK PYVDESRMAI 750
    WGWSYGGFMT LKTLEQDGGR TFQYGMAVAP VTDWRYYDSI YTERYMRTPQ 800
    HNQGGYDTSA ISNTTALASN IRFLLMHGTA DDNVHIQNSL TLLDKLDLDD 850
    VDNYDVHVFP DSDHSIYFHN AHKMVYNRLG DWLINAFNGE WLKVHKPTPN 900
    NSLFRRAETW GGLPV 915
    Length:915
    Mass (Da):102,912
    Last modified:July 28, 2009 - v1
    Checksum:i396FF2E496FA8454
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ999983 Genomic DNA. Translation: EEQ85314.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ999983 Genomic DNA. Translation: EEQ85314.1 .

    3D structure databases

    ProteinModelPortali C5GVF3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Blastomyces dermatitidis strain ER-3."
      Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
      , Galagan J.E., Nusbaum C., Birren B.W.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ER-3 / ATCC MYA-2586.

    Entry informationi

    Entry nameiDAPB_AJEDR
    AccessioniPrimary (citable) accession number: C5GVF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3