C5GKT2 (AMPP2_AJEDR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase BDCG_04966
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

BDCG_04966

Organism

Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis) [Complete proteome]

Taxonomic identifier

559297 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Ajellomycetaceae › Ajellomyces › Ajellomyces dermatitidis

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Probable Xaa-Pro aminopeptidase BDCG_04966		PRO_0000411818
Sites
	Metal binding	285	1	Manganese 2 By similarity
	Metal binding	296	1	Manganese 1 By similarity
	Metal binding	296	1	Manganese 2 By similarity
	Metal binding	433	1	Manganese 1 By similarity
	Metal binding	471	1	Manganese 1 By similarity
	Metal binding	471	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5GKT2 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: E0CCEE9619BBB78B	FASTA	506	56,861
	10 20 30 40 50 60 MISAIEPKNL LRPHSQPVVT TSTLQPDDEC NIELRIEDTT VDKYPAKQHA RRVAAEIHRD 70 80 90 100 110 120 RGLVYLMGQK STLYEDSDQE RTFRQRRYFF YMSGVDEPDC DLTYDINADK LTLYVPDFDL 130 140 150 160 170 180 KRTIWMGPTL GREEALQRFD IDEVKYQSSL DEDVKQWAQN QGRGSTLYLL HESQKPAEKV 190 200 210 220 230 240 PNVFIDSKTL KHAMDTSRAI KDEHEIGLIR RANEVSAAAH IDVLRGIRKM SNERDIEASF 250 260 270 280 290 300 LNTSVSLGAH KQAYHIIAAS GSNAATLHYS KNNEPLKGRQ FVCLDAGAEW NCYASDVTRT 310 320 330 340 350 360 FPMTSQWPSA EAKHIYKLVE HMQESCIVRV KEGVRYLDLH ILAHRSLIRG FLTLGIFKGG 370 380 390 400 410 420 TLEEIQNSGA SNLFFPHGLG HHIGLEVHDV SPESIMAQDN GDYSDNVLIS PNNLSPCTTS 430 440 450 460 470 480 SPTLKSGMVV TIEPGIYFSQ IALDNAKPEQ LKYVDLELVK TYMPVGGVRI EDDILVTKTG 490 500 YENLTTAPKG DGMLEIIRQG DGSCNI

References

[1]

"The genome sequence of Blastomyces dermatitidis strain ER-3." Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S. , Galagan J.E., Nusbaum C., Birren B.W. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ER-3 / ATCC MYA-2586.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EQ999977 Genomic DNA. Translation: EEQ89846.1.
3D structure databases
ProteinModelPortal	C5GKT2.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
OrthoDB	EOG4897VR.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_AJEDR

Accession

Primary (citable) accession number: C5GKT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 28, 2009
Last modified:	March 6, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program