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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei264PROSITE-ProRule annotation1
Active sitei455PROSITE-ProRule annotation1
Active sitei517PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:BDCG_02414
OrganismiAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Taxonomic identifieri559297 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeBlastomyces
Proteomesi
  • UP000002039 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040742018 – 123By similarityAdd BLAST106
ChainiPRO_0000407421124 – 545Carboxypeptidase Y homolog AAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi177 ↔ 416By similarity
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi311 ↔ 325By similarity
Disulfide bondi335 ↔ 358By similarity
Disulfide bondi342 ↔ 351By similarity
Disulfide bondi380 ↔ 386By similarity
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi506N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiC5GEU5

Structurei

3D structure databases

SMRiC5GEU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5GEU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLALALLV GGAIAAGPQQ QVLQAPVDNP DVAEPPLQTI ADTFDHLRGQ
60 70 80 90 100
ATNLWNDVID KVPNIMDTIT HTPPPKKFNR RPDSEWNHIV RGAEIQAVWV
110 120 130 140 150
EGDDGEKHRK VGGKLEAYDL RVKAVDPKSL GVDTVRQYSG YLDDNENDKH
160 170 180 190 200
LFYWFFESRN DPENDPVVLW LNGGPGCSSL TGLFLELGPS SITEDLKVNY
210 220 230 240 250
NPYSWNANAS VIFLDQPVNV GYSYSGGSVS DTNAAGKDVY ALLTLFFEQF
260 270 280 290 300
PEYAKQDFHI AGESYAGHYI PVFASEIMAH KERNINLKSI LIGNGLTDPL
310 320 330 340 350
TQYPLYRPMA CGEGGYPAVL DQASCQSMDN ALPRCLSMIE ACYSSESAWT
360 370 380 390 400
CVPASIYCNN AIIGPYQRTG RNPYDVRTDC EGGNLCYTQL GDISKYLNQA
410 420 430 440 450
EVMKALGAEV STYDSCNMDI NRNFLFRGDW MKPFHRLVPG LIAEMPVLLY
460 470 480 490 500
AGDADFICNW LGNKAWAEAL EYPGHAKFAA AEMKNLTIVD NKSKGKVIGQ
510 520 530 540
VKSAGNFTFM RLYGGGHMVP LDQPEASLEF MNRWLKGEWS AKSSS
Length:545
Mass (Da):60,313
Last modified:July 28, 2009 - v1
Checksum:i0585AD0619F2B453
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ999975 Genomic DNA Translation: EEQ87294.1

Genome annotation databases

EnsemblFungiiEEQ87294; EEQ87294; BDCG_02414

Similar proteinsi

Entry informationi

Entry nameiCBPYA_AJEDR
AccessioniPrimary (citable) accession number: C5GEU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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