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C5GEU5

- CBPYA_AJEDR

UniProt

C5GEU5 - CBPYA_AJEDR

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei264 – 2641PROSITE-ProRule annotation
    Active sitei455 – 4551PROSITE-ProRule annotation
    Active sitei517 – 5171PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:BDCG_02414
    OrganismiAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
    Taxonomic identifieri559297 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
    ProteomesiUP000002039: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 123106By similarityPRO_0000407420Add
    BLAST
    Chaini124 – 545422Carboxypeptidase Y homolog APRO_0000407421Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi177 ↔ 416By similarity
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi311 ↔ 325By similarity
    Disulfide bondi335 ↔ 358By similarity
    Disulfide bondi342 ↔ 351By similarity
    Disulfide bondi380 ↔ 386By similarity
    Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5GEU5-1 [UniParc]FASTAAdd to Basket

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    MKSLALALLV GGAIAAGPQQ QVLQAPVDNP DVAEPPLQTI ADTFDHLRGQ    50
    ATNLWNDVID KVPNIMDTIT HTPPPKKFNR RPDSEWNHIV RGAEIQAVWV 100
    EGDDGEKHRK VGGKLEAYDL RVKAVDPKSL GVDTVRQYSG YLDDNENDKH 150
    LFYWFFESRN DPENDPVVLW LNGGPGCSSL TGLFLELGPS SITEDLKVNY 200
    NPYSWNANAS VIFLDQPVNV GYSYSGGSVS DTNAAGKDVY ALLTLFFEQF 250
    PEYAKQDFHI AGESYAGHYI PVFASEIMAH KERNINLKSI LIGNGLTDPL 300
    TQYPLYRPMA CGEGGYPAVL DQASCQSMDN ALPRCLSMIE ACYSSESAWT 350
    CVPASIYCNN AIIGPYQRTG RNPYDVRTDC EGGNLCYTQL GDISKYLNQA 400
    EVMKALGAEV STYDSCNMDI NRNFLFRGDW MKPFHRLVPG LIAEMPVLLY 450
    AGDADFICNW LGNKAWAEAL EYPGHAKFAA AEMKNLTIVD NKSKGKVIGQ 500
    VKSAGNFTFM RLYGGGHMVP LDQPEASLEF MNRWLKGEWS AKSSS 545
    Length:545
    Mass (Da):60,313
    Last modified:July 28, 2009 - v1
    Checksum:i0585AD0619F2B453
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ999975 Genomic DNA. Translation: EEQ87294.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ999975 Genomic DNA. Translation: EEQ87294.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Blastomyces dermatitidis strain ER-3."
      Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
      , Galagan J.E., Nusbaum C., Birren B.W.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ER-3 / ATCC MYA-2586.

    Entry informationi

    Entry nameiCBPYA_AJEDR
    AccessioniPrimary (citable) accession number: C5GEU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3