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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185By similarity1
Active sitei387By similarity1
Active sitei449By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:BDCG_01958
OrganismiAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Taxonomic identifieri559297 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeBlastomyces
Proteomesi
  • UP000002039 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 520LumenalSequence analysisAdd BLAST487
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 638CytoplasmicSequence analysisAdd BLAST97

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000041189734 – 638Pheromone-processing carboxypeptidase KEX1Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi446N-linked (GlcNAc...)Sequence analysis1
Glycosylationi498N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi564 – 569Poly-Ser6

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5GC75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSETRAYS AWGAWSTWLT ICLALANLLP VTAKSAADYF VDSLPGQPEG
60 70 80 90 100
PLVKMHAGHI EINPETSGNF FFWHFANSHI ADKPRTIVWL NGGPGCSSED
110 120 130 140 150
GALMEIGPYR VTDDHMLNRT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV
160 170 180 190 200
SELDEMTSQF VTFMEKWFEL FPHYEKDDLY FAGESYAGQY IPYIARAILD
210 220 230 240 250
RNKKESVQAQ NRQWNLKGLL IGNGWISPRH QYLSYLPYAY REGIIQGGTD
260 270 280 290 300
ASLRVEATIS KCMKKLNVED TTGTIHIADC EDILQTIVDE THKGNRCINM
310 320 330 340 350
YDIRLTDAYS ACGMNWPPDL KNIEPYLRYK NVTEALHINS DKQTGWTECS
360 370 380 390 400
GAVGGNFRAL KSKPSVELLP RLLEEGLPIL LFSGQKDLIC NHMGTEDMIK
410 420 430 440 450
DMKWSGGTGF ELSPGVWAPR QDWTFEGDSA GFYQQARNLT YVLFYNASHM
460 470 480 490 500
VPFDYPRRTR DMLDKFIGVD ITDIGGNPAD SRIGGEKGPT TSVGGHPNST
510 520 530 540 550
TAAEREKEKM KSAAWKAYYK SGEVALIVVA IAAIIWGVFI WRSRRQKLRN
560 570 580 590 600
PSHEYRGIYP MLGSSSSGSL PRFSNKRGRS ADDVEAADFD ETELDERPSR
610 620 630
AVSSRSSREH EPYAIGEEDG SDREGEGSDE RRRLVDKS
Length:638
Mass (Da):71,527
Last modified:July 28, 2009 - v1
Checksum:i9885B53732257956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ999974 Genomic DNA. Translation: EEQ86838.1.

Genome annotation databases

EnsemblFungiiEEQ86838; EEQ86838; BDCG_01958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ999974 Genomic DNA. Translation: EEQ86838.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ86838; EEQ86838; BDCG_01958.

Phylogenomic databases

OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_AJEDR
AccessioniPrimary (citable) accession number: C5GC75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.