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C5GC75

- KEX1_AJEDR

UniProt

C5GC75 - KEX1_AJEDR

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, BDCG_01958
Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851 By similarity
Active sitei387 – 3871 By similarity
Active sitei449 – 4491 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:BDCG_01958
OrganismiAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Taxonomic identifieri559297 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces
ProteomesiUP000002039: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 520487Lumenal Reviewed prediction
Add
BLAST
Transmembranei521 – 54121Helical; Reviewed prediction
Add
BLAST
Topological domaini542 – 63897Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 638605Pheromone-processing carboxypeptidase KEX1
PRO_0000411897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi438 – 4381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi564 – 5696Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5GC75-1 [UniParc]FASTAAdd to Basket

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MGFSETRAYS AWGAWSTWLT ICLALANLLP VTAKSAADYF VDSLPGQPEG    50
PLVKMHAGHI EINPETSGNF FFWHFANSHI ADKPRTIVWL NGGPGCSSED 100
GALMEIGPYR VTDDHMLNRT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV 150
SELDEMTSQF VTFMEKWFEL FPHYEKDDLY FAGESYAGQY IPYIARAILD 200
RNKKESVQAQ NRQWNLKGLL IGNGWISPRH QYLSYLPYAY REGIIQGGTD 250
ASLRVEATIS KCMKKLNVED TTGTIHIADC EDILQTIVDE THKGNRCINM 300
YDIRLTDAYS ACGMNWPPDL KNIEPYLRYK NVTEALHINS DKQTGWTECS 350
GAVGGNFRAL KSKPSVELLP RLLEEGLPIL LFSGQKDLIC NHMGTEDMIK 400
DMKWSGGTGF ELSPGVWAPR QDWTFEGDSA GFYQQARNLT YVLFYNASHM 450
VPFDYPRRTR DMLDKFIGVD ITDIGGNPAD SRIGGEKGPT TSVGGHPNST 500
TAAEREKEKM KSAAWKAYYK SGEVALIVVA IAAIIWGVFI WRSRRQKLRN 550
PSHEYRGIYP MLGSSSSGSL PRFSNKRGRS ADDVEAADFD ETELDERPSR 600
AVSSRSSREH EPYAIGEEDG SDREGEGSDE RRRLVDKS 638
Length:638
Mass (Da):71,527
Last modified:July 28, 2009 - v1
Checksum:i9885B53732257956
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ999974 Genomic DNA. Translation: EEQ86838.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ999974 Genomic DNA. Translation: EEQ86838.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Blastomyces dermatitidis strain ER-3."
    Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.
    , Galagan J.E., Nusbaum C., Birren B.W.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ER-3 / ATCC MYA-2586.

Entry informationi

Entry nameiKEX1_AJEDR
AccessioniPrimary (citable) accession number: C5GC75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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