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C5GC75 (KEX1_AJEDR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:BDCG_01958
OrganismAjellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis) [Complete proteome]
Taxonomic identifier559297 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 638605Pheromone-processing carboxypeptidase KEX1
PRO_0000411897

Regions

Topological domain34 – 520487Lumenal Potential
Transmembrane521 – 54121Helical; Potential
Topological domain542 – 63897Cytoplasmic Potential
Compositional bias564 – 5696Poly-Ser

Sites

Active site1851 By similarity
Active site3871 By similarity
Active site4491 By similarity

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation4461N-linked (GlcNAc...) Potential
Glycosylation4981N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5GC75 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 9885B53732257956

FASTA63871,527
        10         20         30         40         50         60 
MGFSETRAYS AWGAWSTWLT ICLALANLLP VTAKSAADYF VDSLPGQPEG PLVKMHAGHI 

        70         80         90        100        110        120 
EINPETSGNF FFWHFANSHI ADKPRTIVWL NGGPGCSSED GALMEIGPYR VTDDHMLNRT 

       130        140        150        160        170        180 
DGSWDEFANL LFVDQPVGTG FSYVSTGAYV SELDEMTSQF VTFMEKWFEL FPHYEKDDLY 

       190        200        210        220        230        240 
FAGESYAGQY IPYIARAILD RNKKESVQAQ NRQWNLKGLL IGNGWISPRH QYLSYLPYAY 

       250        260        270        280        290        300 
REGIIQGGTD ASLRVEATIS KCMKKLNVED TTGTIHIADC EDILQTIVDE THKGNRCINM 

       310        320        330        340        350        360 
YDIRLTDAYS ACGMNWPPDL KNIEPYLRYK NVTEALHINS DKQTGWTECS GAVGGNFRAL 

       370        380        390        400        410        420 
KSKPSVELLP RLLEEGLPIL LFSGQKDLIC NHMGTEDMIK DMKWSGGTGF ELSPGVWAPR 

       430        440        450        460        470        480 
QDWTFEGDSA GFYQQARNLT YVLFYNASHM VPFDYPRRTR DMLDKFIGVD ITDIGGNPAD 

       490        500        510        520        530        540 
SRIGGEKGPT TSVGGHPNST TAAEREKEKM KSAAWKAYYK SGEVALIVVA IAAIIWGVFI 

       550        560        570        580        590        600 
WRSRRQKLRN PSHEYRGIYP MLGSSSSGSL PRFSNKRGRS ADDVEAADFD ETELDERPSR 

       610        620        630 
AVSSRSSREH EPYAIGEEDG SDREGEGSDE RRRLVDKS 

« Hide

References

[1]"The genome sequence of Blastomyces dermatitidis strain ER-3."
Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S. expand/collapse author list , Galagan J.E., Nusbaum C., Birren B.W.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ER-3 / ATCC MYA-2586.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ999974 Genomic DNA. Translation: EEQ86838.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
ProtoNetSearch...

Entry information

Entry nameKEX1_AJEDR
AccessionPrimary (citable) accession number: C5GC75
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries