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C5FYZ3 (DAPB_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:MCYG_07560
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]
Taxonomic identifier554155 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length919 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 919919Probable dipeptidyl-aminopeptidase B
PRO_0000412131

Regions

Topological domain1 – 9595Cytoplasmic Potential
Transmembrane96 – 11621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain117 – 919803Vacuolar Potential

Sites

Active site7601Charge relay system By similarity
Active site8371Charge relay system By similarity
Active site8701Charge relay system By similarity

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Potential
Glycosylation6651N-linked (GlcNAc...) Potential
Glycosylation8141N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5FYZ3 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: ECAF6F5752D96F70

FASTA919103,544
        10         20         30         40         50         60 
MGANSRVNDD EAMPLTGHGA GSRDSIDSSS TASISLTLVD GASHTATEPS KSTNGHKSHT 

        70         80         90        100        110        120 
EGSYVNEKYH DSEEESWRED GYVPSGGKPA QRRTRIVFWL LVALCVGGWA MAFIIMATSP 

       130        140        150        160        170        180 
NNRHSTSDSS SGGSESEIVK PNTPHDGKKI PLDDVLGGMW GPVEHTISWI SGPKGEDGLL 

       190        200        210        220        230        240 
LQKSEGGIGP YLHIEDVRNI HGMRANNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL 

       250        260        270        280        290        300 
AMTREKKNWR HSFTGLYWLF DVETQTAQPL DPEAPNGRVQ LASWSPTSDA VVFTRDNNIY 

       310        320        330        340        350        360 
IRNLTSKAVK PITTDGGANL FYGIPDWVYE EEVFEGNSAT WWSLDGKYIS FLRTNETMVP 

       370        380        390        400        410        420 
EFPIDFYLSR PPGYTPEPGE EAYPYVQQIK YPKAGAPNPT VNLQFYDVER EESFSVNVDN 

       430        440        450        460        470        480 
NLKDDDRIIA EVIPASGGKM LVRETNRESY IVKVTVIDAA KREGKMVRSD NVDEIDGGWV 

       490        500        510        520        530        540 
EPSHSTTYIP SDPSAGRPHD GYIDTIIHEG YNHLAYFTPV ENPKPMMLTT GNWEVVDAPS 

       550        560        570        580        590        600 
GVDLKNNVVY FVATKESPID RHVYSVKLDG SELQMLNDSE KSAYYDVSFS NGAGYMLLKY 

       610        620        630        640        650        660 
QGPNIPWQKL ISSPSNEDFY DEIIEENKNL ARLSNEFSLP SLHYSTITVD GFKLPVVERR 

       670        680        690        700        710        720 
PPNFNETKKY PVLFHLYGGP GSQTVNKKFT VNFQTYVASN LGYLVVTVDG RGTGFNGRKF 

       730        740        750        760        770        780 
RCIVRRNLGY YEAHDQIQTA KEWGKKPYVD KTRIAIWGWS YGGFMTLKTL EQDAGETFQY 

       790        800        810        820        830        840 
GMAVAPVTDW RFYDSVYTER YMHMPQHNTE GYENASISNA TSLSQNTRFL IMHGSADDNV 

       850        860        870        880        890        900 
HFQNTLTLLD KLDIMGMHNY DVHVFPDSNH GIYFHHAYKM VHQRLSDWLV NAFNGEWVRL 

       910 
RNPKPSGLKR VIRRLLHFG 

« Hide

References

[1]"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection."
Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. expand/collapse author list , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.
MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995707 Genomic DNA. Translation: EEQ34741.1.
RefSeqXP_002843777.1. XM_002843731.1.

3D structure databases

ProteinModelPortalC5FYZ3.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9225176.

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_ARTOC
AccessionPrimary (citable) accession number: C5FYZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries