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C5FYZ3

- DAPB_ARTOC

UniProt

C5FYZ3 - DAPB_ARTOC

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, MCYG_07560
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei760 – 7601Charge relay system By similarity
Active sitei837 – 8371Charge relay system By similarity
Active sitei870 – 8701Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:MCYG_07560
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei96 – 11621Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini117 – 919803Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Probable dipeptidyl-aminopeptidase BPRO_0000412131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi577 – 5771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi665 – 6651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi814 – 8141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi819 – 8191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC5FYZ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C5FYZ3-1 [UniParc]FASTAAdd to Basket

« Hide

MGANSRVNDD EAMPLTGHGA GSRDSIDSSS TASISLTLVD GASHTATEPS    50
KSTNGHKSHT EGSYVNEKYH DSEEESWRED GYVPSGGKPA QRRTRIVFWL 100
LVALCVGGWA MAFIIMATSP NNRHSTSDSS SGGSESEIVK PNTPHDGKKI 150
PLDDVLGGMW GPVEHTISWI SGPKGEDGLL LQKSEGGIGP YLHIEDVRNI 200
HGMRANNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL AMTREKKNWR 250
HSFTGLYWLF DVETQTAQPL DPEAPNGRVQ LASWSPTSDA VVFTRDNNIY 300
IRNLTSKAVK PITTDGGANL FYGIPDWVYE EEVFEGNSAT WWSLDGKYIS 350
FLRTNETMVP EFPIDFYLSR PPGYTPEPGE EAYPYVQQIK YPKAGAPNPT 400
VNLQFYDVER EESFSVNVDN NLKDDDRIIA EVIPASGGKM LVRETNRESY 450
IVKVTVIDAA KREGKMVRSD NVDEIDGGWV EPSHSTTYIP SDPSAGRPHD 500
GYIDTIIHEG YNHLAYFTPV ENPKPMMLTT GNWEVVDAPS GVDLKNNVVY 550
FVATKESPID RHVYSVKLDG SELQMLNDSE KSAYYDVSFS NGAGYMLLKY 600
QGPNIPWQKL ISSPSNEDFY DEIIEENKNL ARLSNEFSLP SLHYSTITVD 650
GFKLPVVERR PPNFNETKKY PVLFHLYGGP GSQTVNKKFT VNFQTYVASN 700
LGYLVVTVDG RGTGFNGRKF RCIVRRNLGY YEAHDQIQTA KEWGKKPYVD 750
KTRIAIWGWS YGGFMTLKTL EQDAGETFQY GMAVAPVTDW RFYDSVYTER 800
YMHMPQHNTE GYENASISNA TSLSQNTRFL IMHGSADDNV HFQNTLTLLD 850
KLDIMGMHNY DVHVFPDSNH GIYFHHAYKM VHQRLSDWLV NAFNGEWVRL 900
RNPKPSGLKR VIRRLLHFG 919
Length:919
Mass (Da):103,544
Last modified:July 28, 2009 - v1
Checksum:iECAF6F5752D96F70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995707 Genomic DNA. Translation: EEQ34741.1.
RefSeqiXP_002843777.1. XM_002843731.1.

Genome annotation databases

GeneIDi9225176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995707 Genomic DNA. Translation: EEQ34741.1 .
RefSeqi XP_002843777.1. XM_002843731.1.

3D structure databases

ProteinModelPortali C5FYZ3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9225176.

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiDAPB_ARTOC
AccessioniPrimary (citable) accession number: C5FYZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3