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C5FYZ3

- DAPB_ARTOC

UniProt

C5FYZ3 - DAPB_ARTOC

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei760 – 7601Charge relay systemBy similarity
    Active sitei837 – 8371Charge relay systemBy similarity
    Active sitei870 – 8701Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:MCYG_07560
    OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
    Taxonomic identifieri554155 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000002035: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 919919Probable dipeptidyl-aminopeptidase BPRO_0000412131Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi577 – 5771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi814 – 8141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliC5FYZ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini117 – 919803VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5FYZ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGANSRVNDD EAMPLTGHGA GSRDSIDSSS TASISLTLVD GASHTATEPS    50
    KSTNGHKSHT EGSYVNEKYH DSEEESWRED GYVPSGGKPA QRRTRIVFWL 100
    LVALCVGGWA MAFIIMATSP NNRHSTSDSS SGGSESEIVK PNTPHDGKKI 150
    PLDDVLGGMW GPVEHTISWI SGPKGEDGLL LQKSEGGIGP YLHIEDVRNI 200
    HGMRANNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL AMTREKKNWR 250
    HSFTGLYWLF DVETQTAQPL DPEAPNGRVQ LASWSPTSDA VVFTRDNNIY 300
    IRNLTSKAVK PITTDGGANL FYGIPDWVYE EEVFEGNSAT WWSLDGKYIS 350
    FLRTNETMVP EFPIDFYLSR PPGYTPEPGE EAYPYVQQIK YPKAGAPNPT 400
    VNLQFYDVER EESFSVNVDN NLKDDDRIIA EVIPASGGKM LVRETNRESY 450
    IVKVTVIDAA KREGKMVRSD NVDEIDGGWV EPSHSTTYIP SDPSAGRPHD 500
    GYIDTIIHEG YNHLAYFTPV ENPKPMMLTT GNWEVVDAPS GVDLKNNVVY 550
    FVATKESPID RHVYSVKLDG SELQMLNDSE KSAYYDVSFS NGAGYMLLKY 600
    QGPNIPWQKL ISSPSNEDFY DEIIEENKNL ARLSNEFSLP SLHYSTITVD 650
    GFKLPVVERR PPNFNETKKY PVLFHLYGGP GSQTVNKKFT VNFQTYVASN 700
    LGYLVVTVDG RGTGFNGRKF RCIVRRNLGY YEAHDQIQTA KEWGKKPYVD 750
    KTRIAIWGWS YGGFMTLKTL EQDAGETFQY GMAVAPVTDW RFYDSVYTER 800
    YMHMPQHNTE GYENASISNA TSLSQNTRFL IMHGSADDNV HFQNTLTLLD 850
    KLDIMGMHNY DVHVFPDSNH GIYFHHAYKM VHQRLSDWLV NAFNGEWVRL 900
    RNPKPSGLKR VIRRLLHFG 919
    Length:919
    Mass (Da):103,544
    Last modified:July 28, 2009 - v1
    Checksum:iECAF6F5752D96F70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995707 Genomic DNA. Translation: EEQ34741.1.
    RefSeqiXP_002843777.1. XM_002843731.1.

    Genome annotation databases

    GeneIDi9225176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995707 Genomic DNA. Translation: EEQ34741.1 .
    RefSeqi XP_002843777.1. XM_002843731.1.

    3D structure databases

    ProteinModelPortali C5FYZ3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9225176.

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4605 / CBS 113480.

    Entry informationi

    Entry nameiDAPB_ARTOC
    AccessioniPrimary (citable) accession number: C5FYZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3