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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei760 – 7601Charge relay systemBy similarity
Active sitei837 – 8371Charge relay systemBy similarity
Active sitei870 – 8701Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:MCYG_07560
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei96 – 11621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini117 – 919803VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Probable dipeptidyl-aminopeptidase BPRO_0000412131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi577 – 5771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi814 – 8141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC5FYZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C5FYZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGANSRVNDD EAMPLTGHGA GSRDSIDSSS TASISLTLVD GASHTATEPS
60 70 80 90 100
KSTNGHKSHT EGSYVNEKYH DSEEESWRED GYVPSGGKPA QRRTRIVFWL
110 120 130 140 150
LVALCVGGWA MAFIIMATSP NNRHSTSDSS SGGSESEIVK PNTPHDGKKI
160 170 180 190 200
PLDDVLGGMW GPVEHTISWI SGPKGEDGLL LQKSEGGIGP YLHIEDVRNI
210 220 230 240 250
HGMRANNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL AMTREKKNWR
260 270 280 290 300
HSFTGLYWLF DVETQTAQPL DPEAPNGRVQ LASWSPTSDA VVFTRDNNIY
310 320 330 340 350
IRNLTSKAVK PITTDGGANL FYGIPDWVYE EEVFEGNSAT WWSLDGKYIS
360 370 380 390 400
FLRTNETMVP EFPIDFYLSR PPGYTPEPGE EAYPYVQQIK YPKAGAPNPT
410 420 430 440 450
VNLQFYDVER EESFSVNVDN NLKDDDRIIA EVIPASGGKM LVRETNRESY
460 470 480 490 500
IVKVTVIDAA KREGKMVRSD NVDEIDGGWV EPSHSTTYIP SDPSAGRPHD
510 520 530 540 550
GYIDTIIHEG YNHLAYFTPV ENPKPMMLTT GNWEVVDAPS GVDLKNNVVY
560 570 580 590 600
FVATKESPID RHVYSVKLDG SELQMLNDSE KSAYYDVSFS NGAGYMLLKY
610 620 630 640 650
QGPNIPWQKL ISSPSNEDFY DEIIEENKNL ARLSNEFSLP SLHYSTITVD
660 670 680 690 700
GFKLPVVERR PPNFNETKKY PVLFHLYGGP GSQTVNKKFT VNFQTYVASN
710 720 730 740 750
LGYLVVTVDG RGTGFNGRKF RCIVRRNLGY YEAHDQIQTA KEWGKKPYVD
760 770 780 790 800
KTRIAIWGWS YGGFMTLKTL EQDAGETFQY GMAVAPVTDW RFYDSVYTER
810 820 830 840 850
YMHMPQHNTE GYENASISNA TSLSQNTRFL IMHGSADDNV HFQNTLTLLD
860 870 880 890 900
KLDIMGMHNY DVHVFPDSNH GIYFHHAYKM VHQRLSDWLV NAFNGEWVRL
910
RNPKPSGLKR VIRRLLHFG
Length:919
Mass (Da):103,544
Last modified:July 28, 2009 - v1
Checksum:iECAF6F5752D96F70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995707 Genomic DNA. Translation: EEQ34741.1.
RefSeqiXP_002843777.1. XM_002843731.1.

Genome annotation databases

GeneIDi9225176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995707 Genomic DNA. Translation: EEQ34741.1.
RefSeqiXP_002843777.1. XM_002843731.1.

3D structure databases

ProteinModelPortaliC5FYZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9225176.

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiDAPB_ARTOC
AccessioniPrimary (citable) accession number: C5FYZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: January 7, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.