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C5FWJ1 (CBPYA_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:CPYA
ORF Names:MCYG_07094
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]
Taxonomic identifier554155 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 122105 By similarity
PRO_0000407428
Chain123 – 541419Carboxypeptidase Y homolog A
PRO_0000407429

Sites

Active site2641 By similarity
Active site4561 By similarity
Active site5181 By similarity

Amino acid modifications

Glycosylation2081N-linked (GlcNAc...) Potential
Glycosylation5071N-linked (GlcNAc...) Potential
Disulfide bond177 ↔ 417 By similarity
Disulfide bond311 ↔ 325 By similarity
Disulfide bond335 ↔ 358 By similarity
Disulfide bond342 ↔ 351 By similarity
Disulfide bond380 ↔ 387 By similarity

Sequences

Sequence LengthMass (Da)Tools
C5FWJ1 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 5AC030C02D6B5BE1

FASTA54160,467
        10         20         30         40         50         60 
MKLLMTGLLA SAAVAAAQEQ QVLQAEGSAQ QQPAPSIFDE TLKQFESGLE EGITHFWSEM 

        70         80         90        100        110        120 
KTNFKHYLPL ISVPKEHTRR ADSEWDHVVR GADVESVWVQ GANGEKHREI DGKLQSYDLR 

       130        140        150        160        170        180 
VKAVDPAELG IDPGVKQYSG YLDDNETDKH LFYWFFESRN DPKNDPVVLW LNGGPGCSSL 

       190        200        210        220        230        240 
TGLFLELGPA TIDKNLKIVP NPYSWNSNAS VIFLDQPVNV GFSYSGSSVS DTVAAGKDIY 

       250        260        270        280        290        300 
ALLTLFFKQF PEYATQDFHI SGESYAGHYI PVFASEILSH KNTNINLKSV LIGNGLTDPL 

       310        320        330        340        350        360 
TQYPQYRPMA CGDGGYPAVL DQGTCRSMDN SLERCLSLIE TCYSSESAWV CVPAAMYCNS 

       370        380        390        400        410        420 
AIIGPYQQTG MNPYDVRSKC EDMSSLCYPQ LNTITEWLNQ KSVMKALGVE VESYESCNGG 

       430        440        450        460        470        480 
INRDFLFHGD WMKPYHRLVP SLLEKIPVLI YAGDADFICN WLGNLAWTNA LEWPGHKKFA 

       490        500        510        520        530        540 
DAKMNDLKIV DNKSKGKKIG QVKSSGNFTF MRIFGAGHMV PLNQPEASLE FFNRWLRGEW 


R 

« Hide

References

[1]"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection."
Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. expand/collapse author list , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.
MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995706 Genomic DNA. Translation: EEQ34275.1.
RefSeqXP_002845130.1. XM_002845084.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9228162.

Phylogenomic databases

OrthoDBEOG7XDBR1.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_ARTOC
AccessionPrimary (citable) accession number: C5FWJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries