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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei264PROSITE-ProRule annotation1
Active sitei456PROSITE-ProRule annotation1
Active sitei518PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:MCYG_07094
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeMicrosporum
Proteomesi
  • UP000002035 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040742818 – 122By similarityAdd BLAST105
ChainiPRO_0000407429123 – 541Carboxypeptidase Y homolog AAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi177 ↔ 417By similarity
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi311 ↔ 325By similarity
Disulfide bondi335 ↔ 358By similarity
Disulfide bondi342 ↔ 351By similarity
Disulfide bondi380 ↔ 387By similarity
Glycosylationi507N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiC5FWJ1

Interactioni

Protein-protein interaction databases

STRINGi554155.XP_002845130.1

Structurei

3D structure databases

SMRiC5FWJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FWJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLMTGLLA SAAVAAAQEQ QVLQAEGSAQ QQPAPSIFDE TLKQFESGLE
60 70 80 90 100
EGITHFWSEM KTNFKHYLPL ISVPKEHTRR ADSEWDHVVR GADVESVWVQ
110 120 130 140 150
GANGEKHREI DGKLQSYDLR VKAVDPAELG IDPGVKQYSG YLDDNETDKH
160 170 180 190 200
LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLFLELGPA TIDKNLKIVP
210 220 230 240 250
NPYSWNSNAS VIFLDQPVNV GFSYSGSSVS DTVAAGKDIY ALLTLFFKQF
260 270 280 290 300
PEYATQDFHI SGESYAGHYI PVFASEILSH KNTNINLKSV LIGNGLTDPL
310 320 330 340 350
TQYPQYRPMA CGDGGYPAVL DQGTCRSMDN SLERCLSLIE TCYSSESAWV
360 370 380 390 400
CVPAAMYCNS AIIGPYQQTG MNPYDVRSKC EDMSSLCYPQ LNTITEWLNQ
410 420 430 440 450
KSVMKALGVE VESYESCNGG INRDFLFHGD WMKPYHRLVP SLLEKIPVLI
460 470 480 490 500
YAGDADFICN WLGNLAWTNA LEWPGHKKFA DAKMNDLKIV DNKSKGKKIG
510 520 530 540
QVKSSGNFTF MRIFGAGHMV PLNQPEASLE FFNRWLRGEW R
Length:541
Mass (Da):60,467
Last modified:July 28, 2009 - v1
Checksum:i5AC030C02D6B5BE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995706 Genomic DNA Translation: EEQ34275.1
RefSeqiXP_002845130.1, XM_002845084.1

Genome annotation databases

EnsemblFungiiEEQ34275; EEQ34275; MCYG_07094
GeneIDi9228162

Similar proteinsi

Entry informationi

Entry nameiCBPYA_ARTOC
AccessioniPrimary (citable) accession number: C5FWJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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