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C5FWJ1

- CBPYA_ARTOC

UniProt

C5FWJ1 - CBPYA_ARTOC

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei264 – 2641PROSITE-ProRule annotation
    Active sitei456 – 4561PROSITE-ProRule annotation
    Active sitei518 – 5181PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:MCYG_07094
    OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
    Taxonomic identifieri554155 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000002035: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 122105By similarityPRO_0000407428Add
    BLAST
    Chaini123 – 541419Carboxypeptidase Y homolog APRO_0000407429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi177 ↔ 417By similarity
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi311 ↔ 325By similarity
    Disulfide bondi335 ↔ 358By similarity
    Disulfide bondi342 ↔ 351By similarity
    Disulfide bondi380 ↔ 387By similarity
    Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5FWJ1-1 [UniParc]FASTAAdd to Basket

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    MKLLMTGLLA SAAVAAAQEQ QVLQAEGSAQ QQPAPSIFDE TLKQFESGLE    50
    EGITHFWSEM KTNFKHYLPL ISVPKEHTRR ADSEWDHVVR GADVESVWVQ 100
    GANGEKHREI DGKLQSYDLR VKAVDPAELG IDPGVKQYSG YLDDNETDKH 150
    LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLFLELGPA TIDKNLKIVP 200
    NPYSWNSNAS VIFLDQPVNV GFSYSGSSVS DTVAAGKDIY ALLTLFFKQF 250
    PEYATQDFHI SGESYAGHYI PVFASEILSH KNTNINLKSV LIGNGLTDPL 300
    TQYPQYRPMA CGDGGYPAVL DQGTCRSMDN SLERCLSLIE TCYSSESAWV 350
    CVPAAMYCNS AIIGPYQQTG MNPYDVRSKC EDMSSLCYPQ LNTITEWLNQ 400
    KSVMKALGVE VESYESCNGG INRDFLFHGD WMKPYHRLVP SLLEKIPVLI 450
    YAGDADFICN WLGNLAWTNA LEWPGHKKFA DAKMNDLKIV DNKSKGKKIG 500
    QVKSSGNFTF MRIFGAGHMV PLNQPEASLE FFNRWLRGEW R 541
    Length:541
    Mass (Da):60,467
    Last modified:July 28, 2009 - v1
    Checksum:i5AC030C02D6B5BE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995706 Genomic DNA. Translation: EEQ34275.1.
    RefSeqiXP_002845130.1. XM_002845084.1.

    Genome annotation databases

    GeneIDi9228162.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995706 Genomic DNA. Translation: EEQ34275.1 .
    RefSeqi XP_002845130.1. XM_002845084.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9228162.

    Phylogenomic databases

    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4605 / CBS 113480.

    Entry informationi

    Entry nameiCBPYA_ARTOC
    AccessioniPrimary (citable) accession number: C5FWJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3