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C5FWJ1

- CBPYA_ARTOC

UniProt

C5FWJ1 - CBPYA_ARTOC

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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei264 – 2641PROSITE-ProRule annotation
Active sitei456 – 4561PROSITE-ProRule annotation
Active sitei518 – 5181PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:MCYG_07094
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 122105By similarityPRO_0000407428Add
BLAST
Chaini123 – 541419Carboxypeptidase Y homolog APRO_0000407429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi177 ↔ 417By similarity
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi311 ↔ 325By similarity
Disulfide bondi335 ↔ 358By similarity
Disulfide bondi342 ↔ 351By similarity
Disulfide bondi380 ↔ 387By similarity
Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FWJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLMTGLLA SAAVAAAQEQ QVLQAEGSAQ QQPAPSIFDE TLKQFESGLE
60 70 80 90 100
EGITHFWSEM KTNFKHYLPL ISVPKEHTRR ADSEWDHVVR GADVESVWVQ
110 120 130 140 150
GANGEKHREI DGKLQSYDLR VKAVDPAELG IDPGVKQYSG YLDDNETDKH
160 170 180 190 200
LFYWFFESRN DPKNDPVVLW LNGGPGCSSL TGLFLELGPA TIDKNLKIVP
210 220 230 240 250
NPYSWNSNAS VIFLDQPVNV GFSYSGSSVS DTVAAGKDIY ALLTLFFKQF
260 270 280 290 300
PEYATQDFHI SGESYAGHYI PVFASEILSH KNTNINLKSV LIGNGLTDPL
310 320 330 340 350
TQYPQYRPMA CGDGGYPAVL DQGTCRSMDN SLERCLSLIE TCYSSESAWV
360 370 380 390 400
CVPAAMYCNS AIIGPYQQTG MNPYDVRSKC EDMSSLCYPQ LNTITEWLNQ
410 420 430 440 450
KSVMKALGVE VESYESCNGG INRDFLFHGD WMKPYHRLVP SLLEKIPVLI
460 470 480 490 500
YAGDADFICN WLGNLAWTNA LEWPGHKKFA DAKMNDLKIV DNKSKGKKIG
510 520 530 540
QVKSSGNFTF MRIFGAGHMV PLNQPEASLE FFNRWLRGEW R
Length:541
Mass (Da):60,467
Last modified:July 28, 2009 - v1
Checksum:i5AC030C02D6B5BE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995706 Genomic DNA. Translation: EEQ34275.1.
RefSeqiXP_002845130.1. XM_002845084.1.

Genome annotation databases

GeneIDi9228162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995706 Genomic DNA. Translation: EEQ34275.1 .
RefSeqi XP_002845130.1. XM_002845084.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9228162.

Phylogenomic databases

OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiCBPYA_ARTOC
AccessioniPrimary (citable) accession number: C5FWJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3