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Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei238PROSITE-ProRule annotation1
Active sitei458PROSITE-ProRule annotation1
Binding sitei461SubstrateBy similarity1
Active sitei515PROSITE-ProRule annotation1
Binding sitei516SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processVirulence

Protein family/group databases

ESTHERiartoc-spca. Carboxypeptidase_S10.
MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
ORF Names:MCYG_06933
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeMicrosporum
Proteomesi
  • UP000002035 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000038411320 – 625Carboxypeptidase S1 homolog AAdd BLAST606
PropeptideiPRO_0000384114626 – 651Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 121By similarity
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi325 ↔ 361By similarity
Disulfide bondi332 ↔ 354By similarity
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi625GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi554155.XP_002844969.1.

Structurei

3D structure databases

SMRiC5FW30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C16XU.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiView protein in Pfam
PF00450. Peptidase_S10. 1 hit.
PRINTSiPR00724. CRBOXYPTASEC.
PROSITEiView protein in PROSITE
PS00131. CARBOXYPEPT_SER_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FW30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLATGLAVA LPFIGAASAQ YFPPPVEGVT VVESKFDKNV KITYKENDIC
60 70 80 90 100
ETTEGVRSFT GHVHLPPNNN DFGVNQNYSI NTFFWFFEAR EDPKNAPLSI
110 120 130 140 150
WLNGGPGSSS MIGLFQENGP CMVNNDSNST TNNPYSWNNK VNMLYIDQPN
160 170 180 190 200
QVGFSYDVPT NVTVNPINDE VTVADFSNGV PEQNNTLLVG TLGSQNPYAT
210 220 230 240 250
ANNTQNAARS IWHFAQVWFQ EFPEYKPNND KVSIWTESYG GRYGPAFTSY
260 270 280 290 300
FQEQNEKIKN HTITEEGEMH ILHLDTVGII NGCVDLMEQA TSYPDFAYNN
310 320 330 340 350
TYGIKAYNQS QYDSMINEFY RTGGCRDQLI HCRDVAAESD PHFYSHNETV
360 370 380 390 400
NKICNDAGDF CGQKLEDAFE SANLGFYDIA HPLNDPFPPQ FYKGYLSQAH
410 420 430 440 450
VLADMGMPVN FSQASDAVWK AFHTVGDYGR GDVRGYIDDL AYLLENGIKV
460 470 480 490 500
ALVYGDRDYI CNWFGGEKVS LALNYTGTEN FHKAGYTDVK VNSQVGGQVR
510 520 530 540 550
QYGNFSFTRV YEAGHEVPAY QPEVSLEIFH RIMFNKDIAT GEIDIAQKPD
560 570 580 590 600
YSTTGTADTF HIKNDIPPEP EPTCYVLSMG RTCSEEQVKA VKDGTAVVEN
610 620 630 640 650
YIVKSPAGKK QGPPPTSTSP PSPTSSSEGS VKEFSVSVLG VSVLAAITFF

L
Length:651
Mass (Da):72,198
Last modified:July 28, 2009 - v1
Checksum:i074F1DA49231EAE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995706 Genomic DNA. Translation: EEQ34114.1.
RefSeqiXP_002844969.1. XM_002844923.1.

Genome annotation databases

EnsemblFungiiEEQ34114; EEQ34114; MCYG_06933.
GeneIDi9228194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995706 Genomic DNA. Translation: EEQ34114.1.
RefSeqiXP_002844969.1. XM_002844923.1.

3D structure databases

SMRiC5FW30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi554155.XP_002844969.1.

Protein family/group databases

ESTHERiartoc-spca. Carboxypeptidase_S10.
MEROPSiS10.016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ34114; EEQ34114; MCYG_06933.
GeneIDi9228194.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C16XU.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiView protein in Pfam
PF00450. Peptidase_S10. 1 hit.
PRINTSiPR00724. CRBOXYPTASEC.
PROSITEiView protein in PROSITE
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPCA_ARTOC
AccessioniPrimary (citable) accession number: C5FW30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 10, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.