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C5FW30

- SPCA_ARTOC

UniProt

C5FW30 - SPCA_ARTOC

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Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381PROSITE-ProRule annotation
Active sitei458 – 4581PROSITE-ProRule annotation
Binding sitei461 – 4611SubstrateBy similarity
Active sitei515 – 5151PROSITE-ProRule annotation
Binding sitei516 – 5161SubstrateBy similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
ORF Names:MCYG_06933
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 625606Carboxypeptidase S1 homolog APRO_0000384113Add
BLAST
Propeptidei626 – 65126Removed in mature formSequence AnalysisPRO_0000384114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121By similarity
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 361By similarity
Disulfide bondi332 ↔ 354By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
Lipidationi625 – 6251GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7FV40C.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FW30-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLATGLAVA LPFIGAASAQ YFPPPVEGVT VVESKFDKNV KITYKENDIC
60 70 80 90 100
ETTEGVRSFT GHVHLPPNNN DFGVNQNYSI NTFFWFFEAR EDPKNAPLSI
110 120 130 140 150
WLNGGPGSSS MIGLFQENGP CMVNNDSNST TNNPYSWNNK VNMLYIDQPN
160 170 180 190 200
QVGFSYDVPT NVTVNPINDE VTVADFSNGV PEQNNTLLVG TLGSQNPYAT
210 220 230 240 250
ANNTQNAARS IWHFAQVWFQ EFPEYKPNND KVSIWTESYG GRYGPAFTSY
260 270 280 290 300
FQEQNEKIKN HTITEEGEMH ILHLDTVGII NGCVDLMEQA TSYPDFAYNN
310 320 330 340 350
TYGIKAYNQS QYDSMINEFY RTGGCRDQLI HCRDVAAESD PHFYSHNETV
360 370 380 390 400
NKICNDAGDF CGQKLEDAFE SANLGFYDIA HPLNDPFPPQ FYKGYLSQAH
410 420 430 440 450
VLADMGMPVN FSQASDAVWK AFHTVGDYGR GDVRGYIDDL AYLLENGIKV
460 470 480 490 500
ALVYGDRDYI CNWFGGEKVS LALNYTGTEN FHKAGYTDVK VNSQVGGQVR
510 520 530 540 550
QYGNFSFTRV YEAGHEVPAY QPEVSLEIFH RIMFNKDIAT GEIDIAQKPD
560 570 580 590 600
YSTTGTADTF HIKNDIPPEP EPTCYVLSMG RTCSEEQVKA VKDGTAVVEN
610 620 630 640 650
YIVKSPAGKK QGPPPTSTSP PSPTSSSEGS VKEFSVSVLG VSVLAAITFF

L
Length:651
Mass (Da):72,198
Last modified:July 28, 2009 - v1
Checksum:i074F1DA49231EAE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995706 Genomic DNA. Translation: EEQ34114.1.
RefSeqiXP_002844969.1. XM_002844923.1.

Genome annotation databases

GeneIDi9228194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995706 Genomic DNA. Translation: EEQ34114.1 .
RefSeqi XP_002844969.1. XM_002844923.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9228194.

Phylogenomic databases

OrthoDBi EOG7FV40C.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiSPCA_ARTOC
AccessioniPrimary (citable) accession number: C5FW30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3