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C5FW30

- SPCA_ARTOC

UniProt

C5FW30 - SPCA_ARTOC

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Protein

Carboxypeptidase S1 homolog A

Gene
SCPA, MCYG_06933
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381 By similarity
Active sitei458 – 4581 By similarity
Binding sitei461 – 4611Substrate By similarity
Active sitei515 – 5151 By similarity
Binding sitei516 – 5161Substrate By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
ORF Names:MCYG_06933
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035: Unassembled WGS sequence

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 625606Carboxypeptidase S1 homolog APRO_0000384113Add
BLAST
Propeptidei626 – 65126Removed in mature form Reviewed predictionPRO_0000384114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 361 By similarity
Disulfide bondi332 ↔ 354 By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi504 – 5041N-linked (GlcNAc...) Reviewed prediction
Lipidationi625 – 6251GPI-anchor amidated serine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7FV40C.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FW30-1 [UniParc]FASTAAdd to Basket

« Hide

MHLATGLAVA LPFIGAASAQ YFPPPVEGVT VVESKFDKNV KITYKENDIC    50
ETTEGVRSFT GHVHLPPNNN DFGVNQNYSI NTFFWFFEAR EDPKNAPLSI 100
WLNGGPGSSS MIGLFQENGP CMVNNDSNST TNNPYSWNNK VNMLYIDQPN 150
QVGFSYDVPT NVTVNPINDE VTVADFSNGV PEQNNTLLVG TLGSQNPYAT 200
ANNTQNAARS IWHFAQVWFQ EFPEYKPNND KVSIWTESYG GRYGPAFTSY 250
FQEQNEKIKN HTITEEGEMH ILHLDTVGII NGCVDLMEQA TSYPDFAYNN 300
TYGIKAYNQS QYDSMINEFY RTGGCRDQLI HCRDVAAESD PHFYSHNETV 350
NKICNDAGDF CGQKLEDAFE SANLGFYDIA HPLNDPFPPQ FYKGYLSQAH 400
VLADMGMPVN FSQASDAVWK AFHTVGDYGR GDVRGYIDDL AYLLENGIKV 450
ALVYGDRDYI CNWFGGEKVS LALNYTGTEN FHKAGYTDVK VNSQVGGQVR 500
QYGNFSFTRV YEAGHEVPAY QPEVSLEIFH RIMFNKDIAT GEIDIAQKPD 550
YSTTGTADTF HIKNDIPPEP EPTCYVLSMG RTCSEEQVKA VKDGTAVVEN 600
YIVKSPAGKK QGPPPTSTSP PSPTSSSEGS VKEFSVSVLG VSVLAAITFF 650
L 651
Length:651
Mass (Da):72,198
Last modified:July 28, 2009 - v1
Checksum:i074F1DA49231EAE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995706 Genomic DNA. Translation: EEQ34114.1.
RefSeqiXP_002844969.1. XM_002844923.1.

Genome annotation databases

GeneIDi9228194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995706 Genomic DNA. Translation: EEQ34114.1 .
RefSeqi XP_002844969.1. XM_002844923.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9228194.

Phylogenomic databases

OrthoDBi EOG7FV40C.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiSPCA_ARTOC
AccessioniPrimary (citable) accession number: C5FW30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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