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C5FW30 (SPCA_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase S1 homolog A

EC=3.4.16.6
Alternative name(s):
Serine carboxypeptidase A
Short name=SPCA
Gene names
Name:SCPA
ORF Names:MCYG_06933
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]
Taxonomic identifier554155 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length651 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell membrane
Membrane
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 625606Carboxypeptidase S1 homolog A
PRO_0000384113
Propeptide626 – 65126Removed in mature form Potential
PRO_0000384114

Sites

Active site2381 By similarity
Active site4581 By similarity
Active site5151 By similarity
Binding site4611Substrate By similarity
Binding site5161Substrate By similarity

Amino acid modifications

Lipidation6251GPI-anchor amidated serine Potential
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation3081N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation4101N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Glycosylation5041N-linked (GlcNAc...) Potential
Disulfide bond50 ↔ 121 By similarity
Disulfide bond325 ↔ 361 By similarity
Disulfide bond332 ↔ 354 By similarity

Sequences

Sequence LengthMass (Da)Tools
C5FW30 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 074F1DA49231EAE6

FASTA65172,198
        10         20         30         40         50         60 
MHLATGLAVA LPFIGAASAQ YFPPPVEGVT VVESKFDKNV KITYKENDIC ETTEGVRSFT 

        70         80         90        100        110        120 
GHVHLPPNNN DFGVNQNYSI NTFFWFFEAR EDPKNAPLSI WLNGGPGSSS MIGLFQENGP 

       130        140        150        160        170        180 
CMVNNDSNST TNNPYSWNNK VNMLYIDQPN QVGFSYDVPT NVTVNPINDE VTVADFSNGV 

       190        200        210        220        230        240 
PEQNNTLLVG TLGSQNPYAT ANNTQNAARS IWHFAQVWFQ EFPEYKPNND KVSIWTESYG 

       250        260        270        280        290        300 
GRYGPAFTSY FQEQNEKIKN HTITEEGEMH ILHLDTVGII NGCVDLMEQA TSYPDFAYNN 

       310        320        330        340        350        360 
TYGIKAYNQS QYDSMINEFY RTGGCRDQLI HCRDVAAESD PHFYSHNETV NKICNDAGDF 

       370        380        390        400        410        420 
CGQKLEDAFE SANLGFYDIA HPLNDPFPPQ FYKGYLSQAH VLADMGMPVN FSQASDAVWK 

       430        440        450        460        470        480 
AFHTVGDYGR GDVRGYIDDL AYLLENGIKV ALVYGDRDYI CNWFGGEKVS LALNYTGTEN 

       490        500        510        520        530        540 
FHKAGYTDVK VNSQVGGQVR QYGNFSFTRV YEAGHEVPAY QPEVSLEIFH RIMFNKDIAT 

       550        560        570        580        590        600 
GEIDIAQKPD YSTTGTADTF HIKNDIPPEP EPTCYVLSMG RTCSEEQVKA VKDGTAVVEN 

       610        620        630        640        650 
YIVKSPAGKK QGPPPTSTSP PSPTSSSEGS VKEFSVSVLG VSVLAAITFF L 

« Hide

References

[1]"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection."
Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. expand/collapse author list , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.
MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995706 Genomic DNA. Translation: EEQ34114.1.
RefSeqXP_002844969.1. XM_002844923.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9228194.

Phylogenomic databases

OrthoDBEOG7FV40C.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPCA_ARTOC
AccessionPrimary (citable) accession number: C5FW30
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries