C5FUV0 (AMPP2_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase MCYG_06503
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

MCYG_06503

Organism

Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]

Taxonomic identifier

554155 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Arthroderma › Arthroderma otae

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Probable Xaa-Pro aminopeptidase MCYG_06503		PRO_0000411822
Sites
	Metal binding	233	1	Manganese 2 By similarity
	Metal binding	244	1	Manganese 1 By similarity
	Metal binding	244	1	Manganese 2 By similarity
	Metal binding	409	1	Manganese 1 By similarity
	Metal binding	453	1	Manganese 1 By similarity
	Metal binding	453	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5FUV0 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: E61D5F9136D5491C	FASTA	483	53,305
	10 20 30 40 50 60 MTSYSISVSV KGTNINKYPG KQHARRVAAR LAKQKGLIYL PGQQTVLSED SDQARPFKQR 70 80 90 100 110 120 RYFFYVTGVV EPDCHVTYDI AEDKLTLYVP DFDFKRTIWT GPTLGKDDAK QRYDVDAVEY 130 140 150 160 170 180 YSSLEGDVQR WAQGNPSTPI YILHPDQKPV TPLTVAYLYE SKSLQHAMDA CRVIKDEHES 190 200 210 220 230 240 EAQIAGLFID VCLSLRSRGT AYQTIAASGP NGATLHYTRN NEPLAGRQMV VLDAGAEWDC 250 260 270 280 290 300 YASDVTRSFP IPSSVSGKEN SGKGDWPSRE AEEVYAIVQR MQEESISRVR EGAMFFSIHQ 310 320 330 340 350 360 HAHSIALDEL LRLGILRIPH GSSKADLVKA EATALFFPHG LGHHLGLEVH DVAPDSGTVP 370 380 390 400 410 420 VTSSSSSSSS RVTAVTAQCQ DGLMSVTEHR PPCTLSAPPL AAGMVITVEP GIYFNRLAID 430 440 450 460 470 480 QARAERDKPG SKGRFVDFDV VERYMAVGGV RIEDDVLVTK DGSRNLTDAP KGQDMLDMIY DRC

References

[1]

"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection." Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C. MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS995706 Genomic DNA. Translation: EEQ33684.1.
RefSeq	XP_002844539.1. XM_002844493.1.
3D structure databases
ProteinModelPortal	C5FUV0.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9222311.
Phylogenomic databases
OrthoDB	EOG4897VR.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_ARTOC

Accession

Primary (citable) accession number: C5FUV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 28, 2009
Last modified:	March 6, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program