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C5FTV7

- KEX1_ARTOC

UniProt

C5FTV7 - KEX1_ARTOC

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901PROSITE-ProRule annotation
    Active sitei389 – 3891PROSITE-ProRule annotation
    Active sitei451 – 4511PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:MCYG_06129
    OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
    Taxonomic identifieri554155 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000002035: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 636598Pheromone-processing carboxypeptidase KEX1PRO_0000411900Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 522484LumenalSequence AnalysisAdd
    BLAST
    Topological domaini544 – 63693CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi563 – 5708Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5FTV7-1 [UniParc]FASTAAdd to Basket

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    MSATHKMRYN LQLVLPSNTR ARWAWLLLLL SNPAAVLAKC ASDYFVHSLP    50
    GQPEGSVLKM HAGHIEIDSE HKGNLFFWHY QNRHIANRQR TVIWLNGGPG 100
    CSSMDGALME VGPYRLKDDH SLVYNEGSWD EFANLLFVDQ PVGTGFSYVS 150
    TDSYVHELGP MADQFIIFLD RWFKLFPEYE NDDIYLAGES YAGQYIPYIA 200
    KAIVKRNEKL PANQTAWNVE GLIIGNGWIA PNEQYRSYLT YAYKEGILKE 250
    SSEGAQAAEA QLSQCSSKLS EVGKFGIHID ECERVMELIL DTTKINGKCL 300
    NMYDIRLDDT SDSCGMNWPP DISSVTTYLR RPDVVKALNI NEDKTTGWRE 350
    CSPGVGRNLR ATESVPSIQL LPGLLEGGIP VLLFSGDKDL ICNHVGTEDL 400
    IQNMKWSRGT GFELSPGVRA PRHDWVFEGL PAGVYQQARN LTYVKFYNAS 450
    HMVPFDFPRR SRDMLDRFLG VDITTIGGDP ADSRIDGLKG TITSVGAHPN 500
    STTAEEREKE KMKIAAWQAY YKSGEIALIV VAIAATIWGF FVWRSKRREQ 550
    GGEYQGIYPN LESLSSSSLS TFRSKRRGRH DIESTSRSDE AELESLYNGP 600
    EISEVLETQD GRQRELSADG SNEKASASLM VERNLR 636
    Length:636
    Mass (Da):71,407
    Last modified:July 28, 2009 - v1
    Checksum:i547BA0A159BB67C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995705 Genomic DNA. Translation: EEQ33310.1.
    RefSeqiXP_002846260.1. XM_002846214.1.

    Genome annotation databases

    GeneIDi9228429.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995705 Genomic DNA. Translation: EEQ33310.1 .
    RefSeqi XP_002846260.1. XM_002846214.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9228429.

    Phylogenomic databases

    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4605 / CBS 113480.

    Entry informationi

    Entry nameiKEX1_ARTOC
    AccessioniPrimary (citable) accession number: C5FTV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3