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C5FTV7

- KEX1_ARTOC

UniProt

C5FTV7 - KEX1_ARTOC

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, MCYG_06129
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901 By similarity
Active sitei389 – 3891 By similarity
Active sitei451 – 4511 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:MCYG_06129
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 522484Lumenal Reviewed prediction
Add
BLAST
Transmembranei523 – 54321Helical; Reviewed prediction
Add
BLAST
Topological domaini544 – 63693Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed prediction
Add
BLAST
Chaini39 – 636598Pheromone-processing carboxypeptidase KEX1
PRO_0000411900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi563 – 5708Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FTV7-1 [UniParc]FASTAAdd to Basket

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MSATHKMRYN LQLVLPSNTR ARWAWLLLLL SNPAAVLAKC ASDYFVHSLP    50
GQPEGSVLKM HAGHIEIDSE HKGNLFFWHY QNRHIANRQR TVIWLNGGPG 100
CSSMDGALME VGPYRLKDDH SLVYNEGSWD EFANLLFVDQ PVGTGFSYVS 150
TDSYVHELGP MADQFIIFLD RWFKLFPEYE NDDIYLAGES YAGQYIPYIA 200
KAIVKRNEKL PANQTAWNVE GLIIGNGWIA PNEQYRSYLT YAYKEGILKE 250
SSEGAQAAEA QLSQCSSKLS EVGKFGIHID ECERVMELIL DTTKINGKCL 300
NMYDIRLDDT SDSCGMNWPP DISSVTTYLR RPDVVKALNI NEDKTTGWRE 350
CSPGVGRNLR ATESVPSIQL LPGLLEGGIP VLLFSGDKDL ICNHVGTEDL 400
IQNMKWSRGT GFELSPGVRA PRHDWVFEGL PAGVYQQARN LTYVKFYNAS 450
HMVPFDFPRR SRDMLDRFLG VDITTIGGDP ADSRIDGLKG TITSVGAHPN 500
STTAEEREKE KMKIAAWQAY YKSGEIALIV VAIAATIWGF FVWRSKRREQ 550
GGEYQGIYPN LESLSSSSLS TFRSKRRGRH DIESTSRSDE AELESLYNGP 600
EISEVLETQD GRQRELSADG SNEKASASLM VERNLR 636
Length:636
Mass (Da):71,407
Last modified:July 28, 2009 - v1
Checksum:i547BA0A159BB67C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995705 Genomic DNA. Translation: EEQ33310.1.
RefSeqiXP_002846260.1. XM_002846214.1.

Genome annotation databases

GeneIDi9228429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995705 Genomic DNA. Translation: EEQ33310.1 .
RefSeqi XP_002846260.1. XM_002846214.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9228429.

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiKEX1_ARTOC
AccessioniPrimary (citable) accession number: C5FTV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi