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C5FTV7 (KEX1_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:MCYG_06129
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]
Taxonomic identifier554155 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 636598Pheromone-processing carboxypeptidase KEX1
PRO_0000411900

Regions

Topological domain39 – 522484Lumenal Potential
Transmembrane523 – 54321Helical; Potential
Topological domain544 – 63693Cytoplasmic Potential
Compositional bias563 – 5708Poly-Ser

Sites

Active site1901 By similarity
Active site3891 By similarity
Active site4511 By similarity

Amino acid modifications

Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation4401N-linked (GlcNAc...) Potential
Glycosylation4481N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5FTV7 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 547BA0A159BB67C2

FASTA63671,407
        10         20         30         40         50         60 
MSATHKMRYN LQLVLPSNTR ARWAWLLLLL SNPAAVLAKC ASDYFVHSLP GQPEGSVLKM 

        70         80         90        100        110        120 
HAGHIEIDSE HKGNLFFWHY QNRHIANRQR TVIWLNGGPG CSSMDGALME VGPYRLKDDH 

       130        140        150        160        170        180 
SLVYNEGSWD EFANLLFVDQ PVGTGFSYVS TDSYVHELGP MADQFIIFLD RWFKLFPEYE 

       190        200        210        220        230        240 
NDDIYLAGES YAGQYIPYIA KAIVKRNEKL PANQTAWNVE GLIIGNGWIA PNEQYRSYLT 

       250        260        270        280        290        300 
YAYKEGILKE SSEGAQAAEA QLSQCSSKLS EVGKFGIHID ECERVMELIL DTTKINGKCL 

       310        320        330        340        350        360 
NMYDIRLDDT SDSCGMNWPP DISSVTTYLR RPDVVKALNI NEDKTTGWRE CSPGVGRNLR 

       370        380        390        400        410        420 
ATESVPSIQL LPGLLEGGIP VLLFSGDKDL ICNHVGTEDL IQNMKWSRGT GFELSPGVRA 

       430        440        450        460        470        480 
PRHDWVFEGL PAGVYQQARN LTYVKFYNAS HMVPFDFPRR SRDMLDRFLG VDITTIGGDP 

       490        500        510        520        530        540 
ADSRIDGLKG TITSVGAHPN STTAEEREKE KMKIAAWQAY YKSGEIALIV VAIAATIWGF 

       550        560        570        580        590        600 
FVWRSKRREQ GGEYQGIYPN LESLSSSSLS TFRSKRRGRH DIESTSRSDE AELESLYNGP 

       610        620        630 
EISEVLETQD GRQRELSADG SNEKASASLM VERNLR 

« Hide

References

[1]"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection."
Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. expand/collapse author list , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.
MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995705 Genomic DNA. Translation: EEQ33310.1.
RefSeqXP_002846260.1. XM_002846214.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9228429.

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_ARTOC
AccessionPrimary (citable) accession number: C5FTV7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries