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Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981SubstrateBy similarity
Binding sitei279 – 2791SubstrateBy similarity
Binding sitei280 – 2801SubstrateBy similarity
Binding sitei363 – 3631ATPBy similarity
Binding sitei474 – 4741ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi470 – 4712ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:MCYG_05786
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035 Componenti: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Probable D-xylulose kinase APRO_0000393525Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5FSW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSGGPLYI GFDLSTQQLK GLVVSSDLKV VHIAKFDFDS DSKGFNISKG
60 70 80 90 100
VLTNEDEGEV FAPVAMWLQA LDAVLQDLKH QGLDFSLVRG ISGAGQQHGS
110 120 130 140 150
VYWNESAEEI LGGLDGGKTL EDQLQQALSY PYSPNWQDSS TQRECDEFDA
160 170 180 190 200
FLGSEEELAR VTGSKAHHIL RFQRKHPDAY RKTSRISLVS SFLASIFLGS
210 220 230 240 250
VAPFDISDVC GMNLWDMPMN RWNERLLKLC AGEAGPEELK KKLGDVPHDG
260 270 280 290 300
GQELGKISSY FAKRYSFHPD CAITPSTGDN PATILALPLR PLDAMVSLGT
310 320 330 340 350
STTFLMSTPQ YKPDPSTHFF NHPTTPGLYM FMLCYKNGGL AREQVRDAIN
360 370 380 390 400
ATSGEKTDPS NPWSNFDRVL LETPPGGQKA GSGPMKMGLF FPRPEIVPNL
410 420 430 440 450
GEGEWHFNYT PGQANEELKE TDEGWTHPRD DARAIVESQF LSLRLRSKEL
460 470 480 490 500
VHSPSGGVPP QPRRIYLVGG GSRNAAIAKV AGEVLGGIEG VYKLDVGENA
510 520 530 540 550
CALGAAYKAV WALERAPDQT FEDLIGRRWR EDEFVEKIAD GFQPDIFEKY
560 570
RQAVQGFEKM EKQVLMEAKQ
Length:570
Mass (Da):62,891
Last modified:July 28, 2009 - v1
Checksum:i30B542C940D3778D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995705 Genomic DNA. Translation: EEQ32967.1.
RefSeqiXP_002845917.1. XM_002845871.1.

Genome annotation databases

GeneIDi9224217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995705 Genomic DNA. Translation: EEQ32967.1.
RefSeqiXP_002845917.1. XM_002845871.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9224217.

Phylogenomic databases

OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiXKS1_ARTOC
AccessioniPrimary (citable) accession number: C5FSW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: July 28, 2009
Last modified: April 1, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.