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C5FSW4 (XKS1_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable D-xylulose kinase A

Short name=Xylulokinase A
EC=2.7.1.17
Gene names
Name:xkiA
ORF Names:MCYG_05786
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]
Taxonomic identifier554155 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activity

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Subcellular location

Cytoplasm By similarity.

Induction

By D-xylose, L-arabinose or L-arabitol.

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Xylose metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylulokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Probable D-xylulose kinase A
PRO_0000393525

Regions

Nucleotide binding470 – 4712ATP By similarity

Sites

Binding site981Substrate By similarity
Binding site2791Substrate By similarity
Binding site2801Substrate By similarity
Binding site3631ATP By similarity
Binding site4741ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C5FSW4 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 30B542C940D3778D

FASTA57062,891
        10         20         30         40         50         60 
MGSSGGPLYI GFDLSTQQLK GLVVSSDLKV VHIAKFDFDS DSKGFNISKG VLTNEDEGEV 

        70         80         90        100        110        120 
FAPVAMWLQA LDAVLQDLKH QGLDFSLVRG ISGAGQQHGS VYWNESAEEI LGGLDGGKTL 

       130        140        150        160        170        180 
EDQLQQALSY PYSPNWQDSS TQRECDEFDA FLGSEEELAR VTGSKAHHIL RFQRKHPDAY 

       190        200        210        220        230        240 
RKTSRISLVS SFLASIFLGS VAPFDISDVC GMNLWDMPMN RWNERLLKLC AGEAGPEELK 

       250        260        270        280        290        300 
KKLGDVPHDG GQELGKISSY FAKRYSFHPD CAITPSTGDN PATILALPLR PLDAMVSLGT 

       310        320        330        340        350        360 
STTFLMSTPQ YKPDPSTHFF NHPTTPGLYM FMLCYKNGGL AREQVRDAIN ATSGEKTDPS 

       370        380        390        400        410        420 
NPWSNFDRVL LETPPGGQKA GSGPMKMGLF FPRPEIVPNL GEGEWHFNYT PGQANEELKE 

       430        440        450        460        470        480 
TDEGWTHPRD DARAIVESQF LSLRLRSKEL VHSPSGGVPP QPRRIYLVGG GSRNAAIAKV 

       490        500        510        520        530        540 
AGEVLGGIEG VYKLDVGENA CALGAAYKAV WALERAPDQT FEDLIGRRWR EDEFVEKIAD 

       550        560        570 
GFQPDIFEKY RQAVQGFEKM EKQVLMEAKQ 

« Hide

References

[1]"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection."
Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. expand/collapse author list , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.
MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995705 Genomic DNA. Translation: EEQ32967.1.
RefSeqXP_002845917.1. XM_002845871.1.

3D structure databases

ProteinModelPortalC5FSW4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9224217.

Phylogenomic databases

OrthoDBEOG7CRTZN.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXKS1_ARTOC
AccessionPrimary (citable) accession number: C5FSW4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families