Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dipeptidyl peptidase 4

Gene

DPP4

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity (By similarity).By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei613 – 6131Charge relay systemPROSITE-ProRule annotation
Active sitei690 – 6901Charge relay systemPROSITE-ProRule annotation
Active sitei725 – 7251Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Keywords - Biological processi

Virulence

Protein family/group databases

ESTHERinanot-dpp4. DPP4N_Peptidase_S9.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:DPP4
ORF Names:MCYG_02383
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 775760Dipeptidyl peptidase 4PRO_0000384087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi554155.XP_002849449.1.

Structurei

3D structure databases

ProteinModelPortaliC5FJE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FJE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLSLLLLV GVAQAIVPPR EPRPPTGGGK KLLTYKECVP RATLAPRSTS
60 70 80 90 100
LAWINSDEDG QYISQSDDGA LILQNIVTNT NKTLVAADKV PKGFYDYWIK
110 120 130 140 150
PDLTAVLWAT NYTKQYRHSY FANYFILDIE KGSLTPLAED QSGDIQYAQW
160 170 180 190 200
NPVDNSIAYV RGNDLYVWNS GKTKRITENG GPDTFNGVPD WVYEEEIFGD
210 220 230 240 250
RFALWFSPDG EYLAYLRFNE TGVPTYTVPY YKNKQKIAPA YPRELEIRYP
260 270 280 290 300
KVSAKNPTVQ FHLLNLASSE ETSIPVTAFP EDDLIIGEVA WLSSGHDSVA
310 320 330 340 350
FRAFNRVQDT EKIVNVKVGS KESKVIRERD GTDGWIDNLL SMSYIGKVNG
360 370 380 390 400
KEYYVDISDA SGWAHLYLYP VDGGKEIALT KGEWEVTAIL KVDTKSKLIY
410 420 430 440 450
FTSTKFHSTT RHVYSVSYDT KVMTPLVNDR EAAYYSASFS AKGGYYILSY
460 470 480 490 500
QGPNVPYQEL YSVKDKKKPI KTITSNDALI EKLKDYKLPK ITFFEIKLPS
510 520 530 540 550
GESLNVMQRL PPNFNPFKKY PVLFTPYGGP GAQEVSQAWK ALDFKAYITS
560 570 580 590 600
DPELEYVTWT VDNRGTGFKG RKFRSTVTKR LGFLEPQDQV FAAKEILKNR
610 620 630 640 650
WADKDHVGMW GWSYGGFLTA KTMETDSGVF TFGMSTAPVS DFRLYDSMYT
660 670 680 690 700
ERYMKTVELN ADGYSETAVH KTDGFKNLKG HYLIQHGTGD DNVHFQNSAV
710 720 730 740 750
LSNTLMNGGV TPDRLTTQWF TDSDHGVRYD NDSTFQYKQL TKMVYDQKQP
760 770
RPQTTPLHQW SKRVLAALFG EEAEE
Length:775
Mass (Da):87,917
Last modified:September 22, 2009 - v2
Checksum:i311C8FA3E063EA23
GO

Sequence cautioni

The sequence EEQ29564.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995702 Genomic DNA. Translation: EEQ29564.1. Different initiation.
RefSeqiXP_002849449.1. XM_002849403.1.

Genome annotation databases

GeneIDi9226525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995702 Genomic DNA. Translation: EEQ29564.1. Different initiation.
RefSeqiXP_002849449.1. XM_002849403.1.

3D structure databases

ProteinModelPortaliC5FJE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi554155.XP_002849449.1.

Protein family/group databases

ESTHERinanot-dpp4. DPP4N_Peptidase_S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9226525.

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiDPP4_ARTOC
AccessioniPrimary (citable) accession number: C5FJE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 24, 2015
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.