C5FJE3 (DPP4_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dipeptidyl peptidase 4
EC=3.4.14.5

Alternative name(s):
Dipeptidyl peptidase IV
Short name=DPP IV
Short name=DppIV

Gene names

Name:	DPP4
ORF Names:	MCYG_02383

Organism

Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]

Taxonomic identifier

554155 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Arthroderma › Arthroderma otae

Protein attributes

Sequence length	775 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the peptidase S9B family.
Sequence caution	The sequence EEQ29564.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 775	760	Dipeptidyl peptidase 4		PRO_0000384087
Sites
	Active site	613	1	Charge relay system By similarity
	Active site	690	1	Charge relay system By similarity
	Active site	725	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	81	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	219	1	N-linked (GlcNAc...) Potential
	Glycosylation	731	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	C5FJE3 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 311C8FA3E063EA23	FASTA	775	87,917
	10 20 30 40 50 60 MKFLSLLLLV GVAQAIVPPR EPRPPTGGGK KLLTYKECVP RATLAPRSTS LAWINSDEDG 70 80 90 100 110 120 QYISQSDDGA LILQNIVTNT NKTLVAADKV PKGFYDYWIK PDLTAVLWAT NYTKQYRHSY 130 140 150 160 170 180 FANYFILDIE KGSLTPLAED QSGDIQYAQW NPVDNSIAYV RGNDLYVWNS GKTKRITENG 190 200 210 220 230 240 GPDTFNGVPD WVYEEEIFGD RFALWFSPDG EYLAYLRFNE TGVPTYTVPY YKNKQKIAPA 250 260 270 280 290 300 YPRELEIRYP KVSAKNPTVQ FHLLNLASSE ETSIPVTAFP EDDLIIGEVA WLSSGHDSVA 310 320 330 340 350 360 FRAFNRVQDT EKIVNVKVGS KESKVIRERD GTDGWIDNLL SMSYIGKVNG KEYYVDISDA 370 380 390 400 410 420 SGWAHLYLYP VDGGKEIALT KGEWEVTAIL KVDTKSKLIY FTSTKFHSTT RHVYSVSYDT 430 440 450 460 470 480 KVMTPLVNDR EAAYYSASFS AKGGYYILSY QGPNVPYQEL YSVKDKKKPI KTITSNDALI 490 500 510 520 530 540 EKLKDYKLPK ITFFEIKLPS GESLNVMQRL PPNFNPFKKY PVLFTPYGGP GAQEVSQAWK 550 560 570 580 590 600 ALDFKAYITS DPELEYVTWT VDNRGTGFKG RKFRSTVTKR LGFLEPQDQV FAAKEILKNR 610 620 630 640 650 660 WADKDHVGMW GWSYGGFLTA KTMETDSGVF TFGMSTAPVS DFRLYDSMYT ERYMKTVELN 670 680 690 700 710 720 ADGYSETAVH KTDGFKNLKG HYLIQHGTGD DNVHFQNSAV LSNTLMNGGV TPDRLTTQWF 730 740 750 760 770 TDSDHGVRYD NDSTFQYKQL TKMVYDQKQP RPQTTPLHQW SKRVLAALFG EEAEE

References

[1]

"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection." Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C. MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS995702 Genomic DNA. Translation: EEQ29564.1. Different initiation.
RefSeq	XP_002849449.1. XM_002849403.1.
3D structure databases
ProteinModelPortal	C5FJE3.
ModBase	Search...
Protein family/group databases
MEROPS	S09.008.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9226525.
Phylogenomic databases
OrthoDB	EOG4HB1TN.
Family and domain databases
InterPro	IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPP4_ARTOC

Accession

Primary (citable) accession number: C5FJE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	March 6, 2013
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program