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Protein

Carboxypeptidase S1 homolog B

Gene

SCPB

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240PROSITE-ProRule annotation1
Active sitei459PROSITE-ProRule annotation1
Binding sitei462SubstrateBy similarity1
Active sitei517PROSITE-ProRule annotation1
Binding sitei518SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

ESTHERiartoc-scpb. Carboxypeptidase_S10.
MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog B (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase B
Short name:
SPCB
Gene namesi
Name:SCPB
ORF Names:MCYG_02825
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
Proteomesi
  • UP000002035 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000038412122 – 631Carboxypeptidase S1 homolog BAdd BLAST610
PropeptideiPRO_0000384122632 – 655Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 123By similarity
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi328 ↔ 364By similarity
Disulfide bondi335 ↔ 357By similarity
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1
Glycosylationi475N-linked (GlcNAc...)Sequence analysis1
Glycosylationi493N-linked (GlcNAc...)Sequence analysis1
Glycosylationi506N-linked (GlcNAc...)Sequence analysis1
Glycosylationi598N-linked (GlcNAc...)Sequence analysis1
Glycosylationi612N-linked (GlcNAc...)Sequence analysis1
Lipidationi631GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi554155.XP_002849891.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C16XU.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 2 hits.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5FGX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPFARAALC LLAAAGHLAQ AQFPPRPEGV TVLESKFGGG ARISYKEPGL
60 70 80 90 100
CETTEGVKSY AGYVHLPPGT LKDLGVEQDY PINTFFWFFE ARKDPENAPL
110 120 130 140 150
SIWMNGGPGS SSMFGMMTEN GPCFVNPDSN STRLNPHSWN NEVNMLYLDQ
160 170 180 190 200
PVQVGLSYDT LANFTRNLVT DEITKLEPGD PIPEQNATFL VGTYASRNMD
210 220 230 240 250
TTAKGTRNAA IALWHFAQVW FQEFPGYHPR DSRISIATES YGGRYGPAFT
260 270 280 290 300
AFFEEQNQKI KDGTWNGSEG NRHVLHLDTL MIVNGCIDRL VQWPAYPQMA
310 320 330 340 350
YNNTYSIEAV NASIHEGMLD ALYREGGCRD KINHCRSISA VSDPENIGIN
360 370 380 390 400
AMVNDVCKDA ETFCSTEVRD PYQEFSGRNY YDIGQLDPSP FPAPFYMAWL
410 420 430 440 450
NQPHVQAALG VPLNWTQSND VVTTAFRAIG DYPRPGWLED LAYLLENGIK
460 470 480 490 500
VSLVYGDRDY ACNWFGGELS SLAINYTDTQ NFHNAGYAGI QVNSSYIGGQ
510 520 530 540 550
VRQYGNLSFS RVYEAGHEVP SYQPETALQI FHRALFNKDI ATGTIDTSSR
560 570 580 590 600
REDGKFYGSS GPSDSFVFKN EPPPQHVHFC HILDTSTCTK EQIESVENGT
610 620 630 640 650
AVVRSWIVVD SNSTSLFPEV VGSAEPTPMP GAALVSGRIK FHVHVIKSFD

YYIFI
Length:655
Mass (Da):72,791
Last modified:July 28, 2009 - v1
Checksum:i4E95D4568D454EB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995702 Genomic DNA. Translation: EEQ30006.1.
RefSeqiXP_002849891.1. XM_002849845.1.

Genome annotation databases

EnsemblFungiiEEQ30006; EEQ30006; MCYG_02825.
GeneIDi9223265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995702 Genomic DNA. Translation: EEQ30006.1.
RefSeqiXP_002849891.1. XM_002849845.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi554155.XP_002849891.1.

Protein family/group databases

ESTHERiartoc-scpb. Carboxypeptidase_S10.
MEROPSiS10.016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ30006; EEQ30006; MCYG_02825.
GeneIDi9223265.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C16XU.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 2 hits.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCPB_ARTOC
AccessioniPrimary (citable) accession number: C5FGX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.