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C5FGX1

- SCPB_ARTOC

UniProt

C5FGX1 - SCPB_ARTOC

Protein

Carboxypeptidase S1 homolog B

Gene

SCPB

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei240 – 2401PROSITE-ProRule annotation
    Active sitei459 – 4591PROSITE-ProRule annotation
    Binding sitei462 – 4621SubstrateBy similarity
    Active sitei517 – 5171PROSITE-ProRule annotation
    Binding sitei518 – 5181SubstrateBy similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Virulence

    Protein family/group databases

    MEROPSiS10.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase S1 homolog B (EC:3.4.16.6)
    Alternative name(s):
    Serine carboxypeptidase B
    Short name:
    SPCB
    Gene namesi
    Name:SCPB
    ORF Names:MCYG_02825
    OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
    Taxonomic identifieri554155 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000002035: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 631610Carboxypeptidase S1 homolog BPRO_0000384121Add
    BLAST
    Propeptidei632 – 65524Removed in mature formSequence AnalysisPRO_0000384122Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 123By similarity
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi328 ↔ 364By similarity
    Disulfide bondi335 ↔ 357By similarity
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Lipidationi631 – 6311GPI-anchor amidated glycineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7FV40C.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5FGX1-1 [UniParc]FASTAAdd to Basket

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    MRPFARAALC LLAAAGHLAQ AQFPPRPEGV TVLESKFGGG ARISYKEPGL    50
    CETTEGVKSY AGYVHLPPGT LKDLGVEQDY PINTFFWFFE ARKDPENAPL 100
    SIWMNGGPGS SSMFGMMTEN GPCFVNPDSN STRLNPHSWN NEVNMLYLDQ 150
    PVQVGLSYDT LANFTRNLVT DEITKLEPGD PIPEQNATFL VGTYASRNMD 200
    TTAKGTRNAA IALWHFAQVW FQEFPGYHPR DSRISIATES YGGRYGPAFT 250
    AFFEEQNQKI KDGTWNGSEG NRHVLHLDTL MIVNGCIDRL VQWPAYPQMA 300
    YNNTYSIEAV NASIHEGMLD ALYREGGCRD KINHCRSISA VSDPENIGIN 350
    AMVNDVCKDA ETFCSTEVRD PYQEFSGRNY YDIGQLDPSP FPAPFYMAWL 400
    NQPHVQAALG VPLNWTQSND VVTTAFRAIG DYPRPGWLED LAYLLENGIK 450
    VSLVYGDRDY ACNWFGGELS SLAINYTDTQ NFHNAGYAGI QVNSSYIGGQ 500
    VRQYGNLSFS RVYEAGHEVP SYQPETALQI FHRALFNKDI ATGTIDTSSR 550
    REDGKFYGSS GPSDSFVFKN EPPPQHVHFC HILDTSTCTK EQIESVENGT 600
    AVVRSWIVVD SNSTSLFPEV VGSAEPTPMP GAALVSGRIK FHVHVIKSFD 650
    YYIFI 655
    Length:655
    Mass (Da):72,791
    Last modified:July 28, 2009 - v1
    Checksum:i4E95D4568D454EB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995702 Genomic DNA. Translation: EEQ30006.1.
    RefSeqiXP_002849891.1. XM_002849845.1.

    Genome annotation databases

    GeneIDi9223265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995702 Genomic DNA. Translation: EEQ30006.1 .
    RefSeqi XP_002849891.1. XM_002849845.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9223265.

    Phylogenomic databases

    OrthoDBi EOG7FV40C.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4605 / CBS 113480.

    Entry informationi

    Entry nameiSCPB_ARTOC
    AccessioniPrimary (citable) accession number: C5FGX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3