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C5FGX1 (SCPB_ARTOC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase S1 homolog B

EC=3.4.16.6
Alternative name(s):
Serine carboxypeptidase B
Short name=SPCB
Gene names
Name:SCPB
ORF Names:MCYG_02825
OrganismArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) [Complete proteome]
Taxonomic identifier554155 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell membrane
Membrane
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 631610Carboxypeptidase S1 homolog B
PRO_0000384121
Propeptide632 – 65524Removed in mature form Potential
PRO_0000384122

Sites

Active site2401 By similarity
Active site4591 By similarity
Active site5171 By similarity
Binding site4621Substrate By similarity
Binding site5181Substrate By similarity

Amino acid modifications

Lipidation6311GPI-anchor amidated glycine Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential
Glycosylation4751N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Potential
Glycosylation5061N-linked (GlcNAc...) Potential
Glycosylation5981N-linked (GlcNAc...) Potential
Glycosylation6121N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 123 By similarity
Disulfide bond328 ↔ 364 By similarity
Disulfide bond335 ↔ 357 By similarity

Sequences

Sequence LengthMass (Da)Tools
C5FGX1 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 4E95D4568D454EB5

FASTA65572,791
        10         20         30         40         50         60 
MRPFARAALC LLAAAGHLAQ AQFPPRPEGV TVLESKFGGG ARISYKEPGL CETTEGVKSY 

        70         80         90        100        110        120 
AGYVHLPPGT LKDLGVEQDY PINTFFWFFE ARKDPENAPL SIWMNGGPGS SSMFGMMTEN 

       130        140        150        160        170        180 
GPCFVNPDSN STRLNPHSWN NEVNMLYLDQ PVQVGLSYDT LANFTRNLVT DEITKLEPGD 

       190        200        210        220        230        240 
PIPEQNATFL VGTYASRNMD TTAKGTRNAA IALWHFAQVW FQEFPGYHPR DSRISIATES 

       250        260        270        280        290        300 
YGGRYGPAFT AFFEEQNQKI KDGTWNGSEG NRHVLHLDTL MIVNGCIDRL VQWPAYPQMA 

       310        320        330        340        350        360 
YNNTYSIEAV NASIHEGMLD ALYREGGCRD KINHCRSISA VSDPENIGIN AMVNDVCKDA 

       370        380        390        400        410        420 
ETFCSTEVRD PYQEFSGRNY YDIGQLDPSP FPAPFYMAWL NQPHVQAALG VPLNWTQSND 

       430        440        450        460        470        480 
VVTTAFRAIG DYPRPGWLED LAYLLENGIK VSLVYGDRDY ACNWFGGELS SLAINYTDTQ 

       490        500        510        520        530        540 
NFHNAGYAGI QVNSSYIGGQ VRQYGNLSFS RVYEAGHEVP SYQPETALQI FHRALFNKDI 

       550        560        570        580        590        600 
ATGTIDTSSR REDGKFYGSS GPSDSFVFKN EPPPQHVHFC HILDTSTCTK EQIESVENGT 

       610        620        630        640        650 
AVVRSWIVVD SNSTSLFPEV VGSAEPTPMP GAALVSGRIK FHVHVIKSFD YYIFI 

« Hide

References

[1]"Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection."
Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W., Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E., Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I., Rossi A., Saif S. expand/collapse author list , Samalova M., Saunders C.W., Shea T., Summerbell R.C., Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.
MBio 3:E259-E259(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4605 / CBS 113480.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995702 Genomic DNA. Translation: EEQ30006.1.
RefSeqXP_002849891.1. XM_002849845.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9223265.

Phylogenomic databases

OrthoDBEOG7FV40C.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 2 hits.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSCPB_ARTOC
AccessionPrimary (citable) accession number: C5FGX1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries