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C5FEJ1

- MAP21_ARTOC

UniProt

C5FEJ1 - MAP21_ARTOC

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Protein

Methionine aminopeptidase 2-1

Gene

MCYG_01113

Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei215 – 2151SubstrateUniRule annotation
Metal bindingi236 – 2361Divalent metal cation 1UniRule annotation
Metal bindingi247 – 2471Divalent metal cation 1UniRule annotation
Metal bindingi247 – 2471Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi316 – 3161Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei324 – 3241SubstrateUniRule annotation
Metal bindingi349 – 3491Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi444 – 4441Divalent metal cation 1UniRule annotation
Metal bindingi444 – 4441Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-1UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2-1UniRule annotation
Short name:
MetAP 2-1UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:MCYG_01113
OrganismiArthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)
Taxonomic identifieri554155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000002035: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Methionine aminopeptidase 2-1PRO_0000407619Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC5FEJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 836Poly-Lys

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.

Sequencei

Sequence statusi: Complete.

C5FEJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSKTPDGHR QGPNESSTGG TIAVLNPPKS ASASGLVQDA SGEDDEDGDD
60 70 80 90 100
DEEKAGTDLN SRAQPNNDGK KRKRKNNKKK KKKRPLSGQQ TTPPRVALSS
110 120 130 140 150
IFSGQRYPEG EIVKYVTNDD NLQRTTAEEL RHLSVVNNMD DTFLSDYRQA
160 170 180 190 200
AEVHRQVRRY VQTIAKPGIS MSELAQEIED GVRALTGHQG IETGDALKAG
210 220 230 240 250
LAFPTGLCLN NVAAHWTPNP GTKEVILGHD DVLKIDFGVH VHGRIVDSAF
260 270 280 290 300
TVAFNPVYDN LLTAVRAATN TGLKEAGIDA RIDHISGEIQ EVMESYEVEI
310 320 330 340 350
NGNLIPVKAL RSLSGHNILR YKIHGEKQVP FVKSKTTQRM EEGDVFAIET
360 370 380 390 400
FGSTGKGYTR DEAGVYGYGL NEHVSATGLR HASAKSLLKT IRENFGTLVF
410 420 430 440 450
SRRYLEHMGV KNYHLGMRSL ISNDIVECYA PLVDVPGSYV AQFEHTVLLR
460
PNCKEVISRG DDY
Length:463
Mass (Da):50,825
Last modified:July 28, 2009 - v1
Checksum:iE469BEFD96C9E2EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995701 Genomic DNA. Translation: EEQ28225.1.
RefSeqiXP_002851009.1. XM_002850963.1.

Genome annotation databases

GeneIDi9228470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995701 Genomic DNA. Translation: EEQ28225.1 .
RefSeqi XP_002851009.1. XM_002850963.1.

3D structure databases

ProteinModelPortali C5FEJ1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9228470.

Phylogenomic databases

OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4605 / CBS 113480.

Entry informationi

Entry nameiMAP21_ARTOC
AccessioniPrimary (citable) accession number: C5FEJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3