C5E7S2 (C5E7S2_BIFLI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412

Gene names

Name:	proA HAMAP MF_00412
ORF Names:	BLIG_00015 EMBL EEQ54066.1

Organism

Bifidobacterium longum subsp. infantis CCUG 52486 EMBL EEQ54066.1

Taxonomic identifier

537937 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593
Subcellular location	Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis HAMAP MF_00412 SAAS SAAS020593
Cellular component	Cytoplasm HAMAP MF_00412 SAAS SAAS020593
Ligand	NADP HAMAP MF_00412 SAAS SAAS020593
Molecular function	Oxidoreductase HAMAP MF_00412 SAAS SAAS020593
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C5E7S2 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 66243B4679DABEB0	FASTA	431	45,571
	10 20 30 40 50 60 MSDELSPEVF DAVCRQADQA ARAQERLAQA NTEAKNELLL AIADALDEHA ADIEAANALD 70 80 90 100 110 120 MLESKENGMD AGKLDRLLFD VPRVAAAAQG VRHVATLPDP VGEIVRGYNL PNGLRLTQTR 130 140 150 160 170 180 VPMGVIGMIY EARPNVTVDV ASLCLKSGNA ALLRGGHAAE RTNAATLGVI APVLEAHGFE 190 200 210 220 230 240 SALVQSVDQY GRAGATAMME ARGHIDVLVP RGGAGLIQAV VRNSKVPVIE TGAGNVHIYI 250 260 270 280 290 300 DKSGDLAKAI PIIINAKTQR VGVCNAAEKL LVHKDVAAEF LPQIAAALAE ANVVLQTDTT 310 320 330 340 350 360 SYGIISGAAI EGLDLNHAAE EDWDTEYLAL KMGIKVVSDL DAAIDHINTH STGHTESIIA 370 380 390 400 410 420 EDYAAIEEFT KRIDSAVVMV NASTRFTDGG VFGFGAELGI STQKMHARGP MGLREMTTTK 430 WIGYGTGQVR A

References

[1]

"Annotation of Bifidobacterium longum subsp. infantis CCUG 52486." The Broad Institute Genome Sequencing Platform Gougoulias C., Tuohy K.M., Gibson G.R., Ward D., Mehta T., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D., Hepburn T., Shea T., Sykes S., Alvarado L., Kodira C., Borodovsky M., Lander E., Galagan J., Nusbaum C., Birren B. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CCUG 52486 EMBL EEQ54066.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS990238 Genomic DNA. Translation: EEQ54066.1.
3D structure databases
ProteinModelPortal	C5E7S2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	26494621. VBIBifLon94805_0015.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 2 hits. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C5E7S2_BIFLI

Accession

Primary (citable) accession number: C5E7S2

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)