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Protein

Mitogen-activated protein kinase

Gene

KLTH0H08316g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseUniRule annotationSAAS annotation (EC:2.7.11.24UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:KLTH0H08316gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome H

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi381046.XP_002556241.1.

Structurei

3D structure databases

ProteinModelPortaliC5E2W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 304Protein kinaseInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000233024.
InParanoidiC5E2W8.
KOiK04371.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

C5E2W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKIVFNIS SEFQLQQMLG EGAYGVVCSA RHLPTGQMVA IKKIEPFDRP
60 70 80 90 100
LFCLRTLREI KLLRCFQHEN IISIFDIQRP ASFETFSEVY IIQELMDTDL
110 120 130 140 150
HRVITTQTLS DDHVQYFVYQ ILRALKCLHG AEVIHRDLKP SNLLVNANCD
160 170 180 190 200
LKLCDFGLAR CAGGGTKPGD AGHMTEYVAT RWYRAPEVML TAAEYTFAMD
210 220 230 240 250
VWSCGCILAE LLMRRPLFPG KDYHHQLLLI FQVIGSPTAG DLGCVRSKRA
260 270 280 290 300
RQYLNTLPRY AGDGNLRSLV PDASAEALDL LEQMLVFDPR RRITASQALK
310 320 330 340 350
HPYLQAYHDP QDEPATAKVD PALFHFDERK DKLGAGDLKR LLWDEIFGKR

ERTDS
Length:355
Mass (Da):40,348
Last modified:July 28, 2009 - v1
Checksum:iEC604FCEE7D68AD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928180 Genomic DNA. Translation: CAR30379.1.
RefSeqiXP_002556241.1. XM_002556195.1.

Genome annotation databases

EnsemblFungiiCAR30379; CAR30379; KLTH0H08316g.
GeneIDi8294559.
KEGGilth:KLTH0H08316g.

Similar proteinsi

Entry informationi

Entry nameiC5E2W8_LACTC
AccessioniPrimary (citable) accession number: C5E2W8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 27, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported