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C5E216

- C5E216_LACTC

UniProt

C5E216 - C5E216_LACTC

Protein

DNA ligase

Gene

KLTH0H01408g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:KLTH0H01408gImported
    OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
    Taxonomic identifieri559295 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
    ProteomesiUP000002036: Chromosome H

    Interactioni

    Protein-protein interaction databases

    STRINGi559295.KLTH0H01408g.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036006.
    KOiK10747.
    OrthoDBiEOG7TXKRG.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5E216-1 [UniParc]FASTAAdd to Basket

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    MLRLVRAEMS SIKKQATLAK FFSSKKRSVE EEKSHEPAKK LHSDPIGAGS    50
    GSPSSSPPLA TGSSDAGSVK VETSATSTGE NTKAGTPTLP DSDEPAKRAV 100
    AATKGDPAKL GASAPKDSKI LYAEMCNVFN EIEGTSSRLQ IVKLCGDFLY 150
    SVLLKARKDI VPITYLLINK LGPDYQPGLE LGLGEGLLMK TISESCGKSL 200
    QQIKARYREL GDLGRIAQEA RAVQPTMFKP KPLTTGEVFS NLQAIARSQG 250
    KDSQLRKVQL IKRMLTACQG LEAKFLIRSL ESKLRIGLAE KSVLVALSKA 300
    LLTYEHNGKE PSSELVDTAE QKIRDAFCQV PNYQIVIETA LEHGIMELDK 350
    HCVLTPGIPL KPMLAKPSKS ISEVLDRFQG QRFTCEYKYD GERAQVHLLP 400
    DGSMRIYSRN GENMTERYPE IRISDFIADP ARTHTLILDC EAVAWDKEKN 450
    TILPFQVLST RKRKGVAVED VKVRVCLFAF DILCYNDEPL ITRPLAERRA 500
    CLERALVPVP GELQLASEVT TMSLDELQHY LDQAVRDCCE GLMVKILEGE 550
    ESHYEPSKRS RNWLKLKKDY LQGVGDSLDL CVLGAYYGRG KRTGTYGGFL 600
    LGCYNQDSGE YETCCKIGTG FSEEMLQTLF DRLSPTAIPT PKAFYVHSES 650
    APPDVWFEPT LLFEVLTADL SLSPVYKAGT SSYGKGISLR FPRFIRLRDD 700
    KTPEEATSSE QVVEFYESQS HVS 723
    Length:723
    Mass (Da):80,073
    Last modified:July 28, 2009 - v1
    Checksum:iEF9EDC317480A65A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928180 Genomic DNA. Translation: CAR30077.1.
    RefSeqiXP_002555939.1. XM_002555893.1.

    Genome annotation databases

    GeneIDi8294252.
    KEGGilth:KLTH0H01408g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928180 Genomic DNA. Translation: CAR30077.1 .
    RefSeqi XP_002555939.1. XM_002555893.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 559295.KLTH0H01408g.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8294252.
    KEGGi lth:KLTH0H01408g.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036006.
    KOi K10747.
    OrthoDBi EOG7TXKRG.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of protoploid Saccharomycetaceae."
      The Genolevures Consortium
      Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
      , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
      Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284Imported.

    Entry informationi

    Entry nameiC5E216_LACTC
    AccessioniPrimary (citable) accession number: C5E216
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3