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C5DZQ8 (C5DZQ8_ZYGRC) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length1015 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity. PIRNR PIRNR037104

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR037104 SAAS SAAS001214

Subunit structure

Component of the COMPASS (Set1C) complex By similarity. PIRNR PIRNR037104

Subcellular location

Nucleus By similarity PIRNR PIRNR037104.

Sequence similarities

Contains 1 SET domain. RuleBase RU004538

Contains SET domain. SAAS SAAS001214

Contains post-SET domain. SAAS SAAS001214

Sequences

Sequence LengthMass (Da)Tools
C5DZQ8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: DEF92A6E3ED9F35E

FASTA1,015116,520
        10         20         30         40         50         60 
MSGYYRRSYP IPPTGPQRSN FWHESSGSDY NHKPYFNGGY KRYGRYGNFV DNDVSSRNHR 

        70         80         90        100        110        120 
NRREEVNDGS SSSYESPLLN HEEDTKRPIP RVKWDTEELK AKYHYFDVRE KKLIHMEEMT 

       130        140        150        160        170        180 
NWNKDSKYPP NGYVLVQENN MGQPRPVFKQ RVPQEKAVDP RVEQRQQQQQ QQVIPPTYRK 

       190        200        210        220        230        240 
LRSKLALLPH IVYDKFSVGP PPPNEIVLSL LSNVATVQDI SIKNYFKRYG EISHFEAFSD 

       250        260        270        280        290        300 
PNSALPLHIY LIRYGSYSGK LDDAARAAYM AFKDHEGRGC SILGTKFNCT LNKNNILEKT 

       310        320        330        340        350        360 
ISRTVTDNLN RVRKITNDMK KMEKRQKEEE KKESQAYSER KIPLDLAKQI NGRPVLVVSK 

       370        380        390        400        410        420 
SFALHHGLRV EDFKVKLRRY RWSRILDHSS GLYVVFNDLE HARNCQKVES GKMLITSRAK 

       430        440        450        460        470        480 
RAPVDVRFQL IAPTVDKQPT NDINGNHAAL PKSSNQLPTY KTKEELISAA TSYILKDLEN 

       490        500        510        520        530        540 
ALHVDIRKRI IGPAVFDTLN PASFPDLIAK KEVKEKERKE VVAKKAEELK KKQSTNNDFD 

       550        560        570        580        590        600 
IFSLYSGGVT QSNRNRLKRR GSEVIDILPS GRRKLFKGVK PMAHMLNDDS LSKEQTPVAP 

       610        620        630        640        650        660 
STSSPFDESE DEEMTSSDAT EYESGEDDNV EQKKMIKVET ESTTPEIDHA EKPLFVSKKA 

       670        680        690        700        710        720 
EEIMRIPEPY RPSVGGLPKP IQPDDTIRPN LFIDDLQKTV TDMEDLFILK KVLGLDEPNQ 

       730        740        750        760        770        780 
NDEKSEHDGT LEYRIWKLRS QAQNFRVDQE NQLRLLGAPL DSLLLTGNGS FKAQGYRKIP 

       790        800        810        820        830        840 
EKLKSCYLPH RRKPHQPLNT VSYHSETKDG TPEVEREESE NLEEPESVPQ EISSSRDNRA 

       850        860        870        880        890        900 
SNRRFQQDIE AQRAAIGTES ELLSLNQLNK RKKPVTFARS TIHNWGLYAL EPIAAKEMII 

       910        920        930        940        950        960 
EYVGERIRQP VAEMREIRYL KSGIGSSYLF RIDENTVIDA TKKGGIARFI NHCCEPSCTA 

       970        980        990       1000       1010 
KIIKVGGMKR IVIYALRDIG ANEELTYDYK FEREIDAEER LPCLCGAPSC KGFLN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU928179 Genomic DNA. Translation: CAR29342.1.
RefSeqXP_002498275.1. XM_002498230.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING559307.ZYRO0G06446g.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8206075.
KEGGzro:ZYRO0G06446g.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000066111.
KOK11422.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR015722. Histone-lysine_MeTfrase.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PANTHERPTHR22884:SF10. PTHR22884:SF10. 1 hit.
PfamPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5DZQ8_ZYGRC
AccessionPrimary (citable) accession number: C5DZQ8
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)