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C5DZQ8

- C5DZQ8_ZYGRC

UniProt

C5DZQ8 - C5DZQ8_ZYGRC

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene
ZYRO0G06446g
Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Ordered Locus Names:ZYRO0G06446gImported
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
ProteomesiUP000008536: Chromosome G

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi559307.ZYRO0G06446g.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000066111.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DZQ8-1 [UniParc]FASTAAdd to Basket

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MSGYYRRSYP IPPTGPQRSN FWHESSGSDY NHKPYFNGGY KRYGRYGNFV     50
DNDVSSRNHR NRREEVNDGS SSSYESPLLN HEEDTKRPIP RVKWDTEELK 100
AKYHYFDVRE KKLIHMEEMT NWNKDSKYPP NGYVLVQENN MGQPRPVFKQ 150
RVPQEKAVDP RVEQRQQQQQ QQVIPPTYRK LRSKLALLPH IVYDKFSVGP 200
PPPNEIVLSL LSNVATVQDI SIKNYFKRYG EISHFEAFSD PNSALPLHIY 250
LIRYGSYSGK LDDAARAAYM AFKDHEGRGC SILGTKFNCT LNKNNILEKT 300
ISRTVTDNLN RVRKITNDMK KMEKRQKEEE KKESQAYSER KIPLDLAKQI 350
NGRPVLVVSK SFALHHGLRV EDFKVKLRRY RWSRILDHSS GLYVVFNDLE 400
HARNCQKVES GKMLITSRAK RAPVDVRFQL IAPTVDKQPT NDINGNHAAL 450
PKSSNQLPTY KTKEELISAA TSYILKDLEN ALHVDIRKRI IGPAVFDTLN 500
PASFPDLIAK KEVKEKERKE VVAKKAEELK KKQSTNNDFD IFSLYSGGVT 550
QSNRNRLKRR GSEVIDILPS GRRKLFKGVK PMAHMLNDDS LSKEQTPVAP 600
STSSPFDESE DEEMTSSDAT EYESGEDDNV EQKKMIKVET ESTTPEIDHA 650
EKPLFVSKKA EEIMRIPEPY RPSVGGLPKP IQPDDTIRPN LFIDDLQKTV 700
TDMEDLFILK KVLGLDEPNQ NDEKSEHDGT LEYRIWKLRS QAQNFRVDQE 750
NQLRLLGAPL DSLLLTGNGS FKAQGYRKIP EKLKSCYLPH RRKPHQPLNT 800
VSYHSETKDG TPEVEREESE NLEEPESVPQ EISSSRDNRA SNRRFQQDIE 850
AQRAAIGTES ELLSLNQLNK RKKPVTFARS TIHNWGLYAL EPIAAKEMII 900
EYVGERIRQP VAEMREIRYL KSGIGSSYLF RIDENTVIDA TKKGGIARFI 950
NHCCEPSCTA KIIKVGGMKR IVIYALRDIG ANEELTYDYK FEREIDAEER 1000
LPCLCGAPSC KGFLN 1015
Length:1,015
Mass (Da):116,520
Last modified:July 28, 2009 - v1
Checksum:iDEF92A6E3ED9F35E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928179 Genomic DNA. Translation: CAR29342.1.
RefSeqiXP_002498275.1. XM_002498230.1.

Genome annotation databases

GeneIDi8206075.
KEGGizro:ZYRO0G06446g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928179 Genomic DNA. Translation: CAR29342.1 .
RefSeqi XP_002498275.1. XM_002498230.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 559307.ZYRO0G06446g.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8206075.
KEGGi zro:ZYRO0G06446g.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000066111.
KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229.

Entry informationi

Entry nameiC5DZQ8_ZYGRC
AccessioniPrimary (citable) accession number: C5DZQ8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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