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C5DZQ8

- C5DZQ8_ZYGRC

UniProt

C5DZQ8 - C5DZQ8_ZYGRC

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

ZYRO0G06446g

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    Ordered Locus Names:ZYRO0G06446gImported
    OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)Imported
    Taxonomic identifieri559307 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
    ProteomesiUP000008536: Chromosome G

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi559307.ZYRO0G06446g.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000066111.
    KOiK11422.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5DZQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGYYRRSYP IPPTGPQRSN FWHESSGSDY NHKPYFNGGY KRYGRYGNFV     50
    DNDVSSRNHR NRREEVNDGS SSSYESPLLN HEEDTKRPIP RVKWDTEELK 100
    AKYHYFDVRE KKLIHMEEMT NWNKDSKYPP NGYVLVQENN MGQPRPVFKQ 150
    RVPQEKAVDP RVEQRQQQQQ QQVIPPTYRK LRSKLALLPH IVYDKFSVGP 200
    PPPNEIVLSL LSNVATVQDI SIKNYFKRYG EISHFEAFSD PNSALPLHIY 250
    LIRYGSYSGK LDDAARAAYM AFKDHEGRGC SILGTKFNCT LNKNNILEKT 300
    ISRTVTDNLN RVRKITNDMK KMEKRQKEEE KKESQAYSER KIPLDLAKQI 350
    NGRPVLVVSK SFALHHGLRV EDFKVKLRRY RWSRILDHSS GLYVVFNDLE 400
    HARNCQKVES GKMLITSRAK RAPVDVRFQL IAPTVDKQPT NDINGNHAAL 450
    PKSSNQLPTY KTKEELISAA TSYILKDLEN ALHVDIRKRI IGPAVFDTLN 500
    PASFPDLIAK KEVKEKERKE VVAKKAEELK KKQSTNNDFD IFSLYSGGVT 550
    QSNRNRLKRR GSEVIDILPS GRRKLFKGVK PMAHMLNDDS LSKEQTPVAP 600
    STSSPFDESE DEEMTSSDAT EYESGEDDNV EQKKMIKVET ESTTPEIDHA 650
    EKPLFVSKKA EEIMRIPEPY RPSVGGLPKP IQPDDTIRPN LFIDDLQKTV 700
    TDMEDLFILK KVLGLDEPNQ NDEKSEHDGT LEYRIWKLRS QAQNFRVDQE 750
    NQLRLLGAPL DSLLLTGNGS FKAQGYRKIP EKLKSCYLPH RRKPHQPLNT 800
    VSYHSETKDG TPEVEREESE NLEEPESVPQ EISSSRDNRA SNRRFQQDIE 850
    AQRAAIGTES ELLSLNQLNK RKKPVTFARS TIHNWGLYAL EPIAAKEMII 900
    EYVGERIRQP VAEMREIRYL KSGIGSSYLF RIDENTVIDA TKKGGIARFI 950
    NHCCEPSCTA KIIKVGGMKR IVIYALRDIG ANEELTYDYK FEREIDAEER 1000
    LPCLCGAPSC KGFLN 1015
    Length:1,015
    Mass (Da):116,520
    Last modified:July 28, 2009 - v1
    Checksum:iDEF92A6E3ED9F35E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928179 Genomic DNA. Translation: CAR29342.1.
    RefSeqiXP_002498275.1. XM_002498230.1.

    Genome annotation databases

    GeneIDi8206075.
    KEGGizro:ZYRO0G06446g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928179 Genomic DNA. Translation: CAR29342.1 .
    RefSeqi XP_002498275.1. XM_002498230.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 559307.ZYRO0G06446g.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8206075.
    KEGGi zro:ZYRO0G06446g.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000066111.
    KOi K11422.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of protoploid Saccharomycetaceae."
      The Genolevures Consortium
      Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
      , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
      Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229Imported.

    Entry informationi

    Entry nameiC5DZQ8_ZYGRC
    AccessioniPrimary (citable) accession number: C5DZQ8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3