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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

ZYRO0G06446g

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Ordered Locus Names:ZYRO0G06446gImported
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)Imported
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
ProteomesiUP000008536 Componenti: Chromosome G

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi559307.ZYRO0G06446g.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000066111.
InParanoidiC5DZQ8.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DZQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYYRRSYP IPPTGPQRSN FWHESSGSDY NHKPYFNGGY KRYGRYGNFV
60 70 80 90 100
DNDVSSRNHR NRREEVNDGS SSSYESPLLN HEEDTKRPIP RVKWDTEELK
110 120 130 140 150
AKYHYFDVRE KKLIHMEEMT NWNKDSKYPP NGYVLVQENN MGQPRPVFKQ
160 170 180 190 200
RVPQEKAVDP RVEQRQQQQQ QQVIPPTYRK LRSKLALLPH IVYDKFSVGP
210 220 230 240 250
PPPNEIVLSL LSNVATVQDI SIKNYFKRYG EISHFEAFSD PNSALPLHIY
260 270 280 290 300
LIRYGSYSGK LDDAARAAYM AFKDHEGRGC SILGTKFNCT LNKNNILEKT
310 320 330 340 350
ISRTVTDNLN RVRKITNDMK KMEKRQKEEE KKESQAYSER KIPLDLAKQI
360 370 380 390 400
NGRPVLVVSK SFALHHGLRV EDFKVKLRRY RWSRILDHSS GLYVVFNDLE
410 420 430 440 450
HARNCQKVES GKMLITSRAK RAPVDVRFQL IAPTVDKQPT NDINGNHAAL
460 470 480 490 500
PKSSNQLPTY KTKEELISAA TSYILKDLEN ALHVDIRKRI IGPAVFDTLN
510 520 530 540 550
PASFPDLIAK KEVKEKERKE VVAKKAEELK KKQSTNNDFD IFSLYSGGVT
560 570 580 590 600
QSNRNRLKRR GSEVIDILPS GRRKLFKGVK PMAHMLNDDS LSKEQTPVAP
610 620 630 640 650
STSSPFDESE DEEMTSSDAT EYESGEDDNV EQKKMIKVET ESTTPEIDHA
660 670 680 690 700
EKPLFVSKKA EEIMRIPEPY RPSVGGLPKP IQPDDTIRPN LFIDDLQKTV
710 720 730 740 750
TDMEDLFILK KVLGLDEPNQ NDEKSEHDGT LEYRIWKLRS QAQNFRVDQE
760 770 780 790 800
NQLRLLGAPL DSLLLTGNGS FKAQGYRKIP EKLKSCYLPH RRKPHQPLNT
810 820 830 840 850
VSYHSETKDG TPEVEREESE NLEEPESVPQ EISSSRDNRA SNRRFQQDIE
860 870 880 890 900
AQRAAIGTES ELLSLNQLNK RKKPVTFARS TIHNWGLYAL EPIAAKEMII
910 920 930 940 950
EYVGERIRQP VAEMREIRYL KSGIGSSYLF RIDENTVIDA TKKGGIARFI
960 970 980 990 1000
NHCCEPSCTA KIIKVGGMKR IVIYALRDIG ANEELTYDYK FEREIDAEER
1010
LPCLCGAPSC KGFLN
Length:1,015
Mass (Da):116,520
Last modified:July 28, 2009 - v1
Checksum:iDEF92A6E3ED9F35E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928179 Genomic DNA. Translation: CAR29342.1.
RefSeqiXP_002498275.1. XM_002498230.1.

Genome annotation databases

GeneIDi8206075.
KEGGizro:ZYRO0G06446g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928179 Genomic DNA. Translation: CAR29342.1.
RefSeqiXP_002498275.1. XM_002498230.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi559307.ZYRO0G06446g.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8206075.
KEGGizro:ZYRO0G06446g.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000066111.
InParanoidiC5DZQ8.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229Imported.

Entry informationi

Entry nameiC5DZQ8_ZYGRC
AccessioniPrimary (citable) accession number: C5DZQ8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 1, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.