Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

ZYRO0D13200g

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei418 – 4181S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:ZYRO0D13200gImported
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)Imported
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
ProteomesiUP000008536 Componenti: Chromosome D

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi4956.XP_002497007.1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3714S-adenosyl-L-methionine bindingUniRule annotation
Regioni391 – 40010S-adenosyl-L-methionine bindingUniRule annotation
Regioni455 – 4562S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000112251.
InParanoidiC5DWA5.
KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DWA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDPIDDNST ENFSQVPTTS SSGSGSKRSR KNRTTELQGL LDEANKYNSH
60 70 80 90 100
YEYDMPRGFL RDKSSKEDVI QEEETEDSKE SLVPRKKSKG GRPRKNDINR
110 120 130 140 150
QNGTKRSIPS PQTLIEEPAP KKKSGRVRSR KTDTGHRQDS TGSLTPMTPS
160 170 180 190 200
SQGSEDTNTA VTAHLDDSRV RNQEKQNGVD NTFTNWNAST NDVRFDIIDL
210 220 230 240 250
EYIKSHTYFE GEPTPSTVLT AKRREKSTEV ITVKLQSVLF ENYQEEYDIC
260 270 280 290 300
FTKDLNVYNP MSEIGKIVEY MAAIFLPLQP ATKVQREVIP PMNRAFDEED
310 320 330 340 350
IHTFVQMVEK YNEIVLSVTR QETIDHLSTV KRIPSIFIHD FLHMVYTRSI
360 370 380 390 400
FPQCRRLKQY EAFSNYVYGE LLPGFLTEAF VKCQLNPNQL FMDLGSGVGN
410 420 430 440 450
CVVQAALECG CGLSFGCEIM PNASDLTEAQ YKELVQRCKL FGLKLPSIEY
460 470 480 490 500
SLRQSFIDNK RVDELIPQCD VLLINNFLFD SDMNLQVEKL IQNAKVGCKI
510 520 530 540 550
ITLKNLRASG YTINFYNLES ILNRLRVERF ELKEDSVSWT HSGGEYYIST
560 570
VMETMDESLF DPSLRQRSTR RPTRYTR
Length:577
Mass (Da):66,134
Last modified:July 28, 2009 - v1
Checksum:i39EF7652FA801FD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928176 Genomic DNA. Translation: CAR28074.1.
RefSeqiXP_002497007.1. XM_002496962.1.

Genome annotation databases

GeneIDi8204269.
KEGGizro:ZYRO0D13200g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928176 Genomic DNA. Translation: CAR28074.1.
RefSeqiXP_002497007.1. XM_002496962.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4956.XP_002497007.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8204269.
KEGGizro:ZYRO0D13200g.

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000112251.
InParanoidiC5DWA5.
KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Genolevures Consortium, Souciet J.L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B.
    , Val M.E., Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.F., Sacerdot C., Straub M.L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229Imported.

Entry informationi

Entry nameiC5DWA5_ZYGRC
AccessioniPrimary (citable) accession number: C5DWA5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: June 24, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.