Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C5DWA5 (C5DWA5_ZYGRC) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
Ordered Locus Names:ZYRO0D13200g EMBL CAR28074.1
OrganismZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii) [Complete proteome]
Taxonomic identifier559307 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region368 – 3714S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region391 – 40010S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region455 – 4562S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site4181S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
C5DWA5 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 39EF7652FA801FD7

FASTA57766,134
        10         20         30         40         50         60 
MTDPIDDNST ENFSQVPTTS SSGSGSKRSR KNRTTELQGL LDEANKYNSH YEYDMPRGFL 

        70         80         90        100        110        120 
RDKSSKEDVI QEEETEDSKE SLVPRKKSKG GRPRKNDINR QNGTKRSIPS PQTLIEEPAP 

       130        140        150        160        170        180 
KKKSGRVRSR KTDTGHRQDS TGSLTPMTPS SQGSEDTNTA VTAHLDDSRV RNQEKQNGVD 

       190        200        210        220        230        240 
NTFTNWNAST NDVRFDIIDL EYIKSHTYFE GEPTPSTVLT AKRREKSTEV ITVKLQSVLF 

       250        260        270        280        290        300 
ENYQEEYDIC FTKDLNVYNP MSEIGKIVEY MAAIFLPLQP ATKVQREVIP PMNRAFDEED 

       310        320        330        340        350        360 
IHTFVQMVEK YNEIVLSVTR QETIDHLSTV KRIPSIFIHD FLHMVYTRSI FPQCRRLKQY 

       370        380        390        400        410        420 
EAFSNYVYGE LLPGFLTEAF VKCQLNPNQL FMDLGSGVGN CVVQAALECG CGLSFGCEIM 

       430        440        450        460        470        480 
PNASDLTEAQ YKELVQRCKL FGLKLPSIEY SLRQSFIDNK RVDELIPQCD VLLINNFLFD 

       490        500        510        520        530        540 
SDMNLQVEKL IQNAKVGCKI ITLKNLRASG YTINFYNLES ILNRLRVERF ELKEDSVSWT 

       550        560        570 
HSGGEYYIST VMETMDESLF DPSLRQRSTR RPTRYTR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU928176 Genomic DNA. Translation: CAR28074.1.
RefSeqXP_002497007.1. XM_002496962.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING559307.ZYRO0D13200g.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8204269.
KEGGzro:ZYRO0D13200g.

Phylogenomic databases

eggNOGNOG294902.
HOGENOMHOG000112251.
KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5DWA5_ZYGRC
AccessionPrimary (citable) accession number: C5DWA5
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)