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C5DWA5

- C5DWA5_ZYGRC

UniProt

C5DWA5 - C5DWA5_ZYGRC

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

ZYRO0D13200g

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei418 – 4181S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    Ordered Locus Names:ZYRO0D13200gImported
    OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)Imported
    Taxonomic identifieri559307 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
    ProteomesiUP000008536: Chromosome D

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi559307.ZYRO0D13200g.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni368 – 3714S-adenosyl-L-methionine bindingUniRule annotation
    Regioni391 – 40010S-adenosyl-L-methionine bindingUniRule annotation
    Regioni455 – 4562S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    HOGENOMiHOG000112251.
    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5DWA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDPIDDNST ENFSQVPTTS SSGSGSKRSR KNRTTELQGL LDEANKYNSH    50
    YEYDMPRGFL RDKSSKEDVI QEEETEDSKE SLVPRKKSKG GRPRKNDINR 100
    QNGTKRSIPS PQTLIEEPAP KKKSGRVRSR KTDTGHRQDS TGSLTPMTPS 150
    SQGSEDTNTA VTAHLDDSRV RNQEKQNGVD NTFTNWNAST NDVRFDIIDL 200
    EYIKSHTYFE GEPTPSTVLT AKRREKSTEV ITVKLQSVLF ENYQEEYDIC 250
    FTKDLNVYNP MSEIGKIVEY MAAIFLPLQP ATKVQREVIP PMNRAFDEED 300
    IHTFVQMVEK YNEIVLSVTR QETIDHLSTV KRIPSIFIHD FLHMVYTRSI 350
    FPQCRRLKQY EAFSNYVYGE LLPGFLTEAF VKCQLNPNQL FMDLGSGVGN 400
    CVVQAALECG CGLSFGCEIM PNASDLTEAQ YKELVQRCKL FGLKLPSIEY 450
    SLRQSFIDNK RVDELIPQCD VLLINNFLFD SDMNLQVEKL IQNAKVGCKI 500
    ITLKNLRASG YTINFYNLES ILNRLRVERF ELKEDSVSWT HSGGEYYIST 550
    VMETMDESLF DPSLRQRSTR RPTRYTR 577
    Length:577
    Mass (Da):66,134
    Last modified:July 28, 2009 - v1
    Checksum:i39EF7652FA801FD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928176 Genomic DNA. Translation: CAR28074.1.
    RefSeqiXP_002497007.1. XM_002496962.1.

    Genome annotation databases

    GeneIDi8204269.
    KEGGizro:ZYRO0D13200g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928176 Genomic DNA. Translation: CAR28074.1 .
    RefSeqi XP_002497007.1. XM_002496962.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 559307.ZYRO0D13200g.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8204269.
    KEGGi zro:ZYRO0D13200g.

    Phylogenomic databases

    eggNOGi NOG294902.
    HOGENOMi HOG000112251.
    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of protoploid Saccharomycetaceae."
      The Genolevures Consortium
      Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
      , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
      Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229Imported.

    Entry informationi

    Entry nameiC5DWA5_ZYGRC
    AccessioniPrimary (citable) accession number: C5DWA5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3