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C5DWA5

- C5DWA5_ZYGRC

UniProt

C5DWA5 - C5DWA5_ZYGRC

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

ZYRO0D13200g

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei418 – 4181S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:ZYRO0D13200gImported
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)Imported
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
ProteomesiUP000008536: Chromosome D

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi559307.ZYRO0D13200g.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3714S-adenosyl-L-methionine bindingUniRule annotation
Regioni391 – 40010S-adenosyl-L-methionine bindingUniRule annotation
Regioni455 – 4562S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000112251.
InParanoidiC5DWA5.
KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DWA5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDPIDDNST ENFSQVPTTS SSGSGSKRSR KNRTTELQGL LDEANKYNSH
60 70 80 90 100
YEYDMPRGFL RDKSSKEDVI QEEETEDSKE SLVPRKKSKG GRPRKNDINR
110 120 130 140 150
QNGTKRSIPS PQTLIEEPAP KKKSGRVRSR KTDTGHRQDS TGSLTPMTPS
160 170 180 190 200
SQGSEDTNTA VTAHLDDSRV RNQEKQNGVD NTFTNWNAST NDVRFDIIDL
210 220 230 240 250
EYIKSHTYFE GEPTPSTVLT AKRREKSTEV ITVKLQSVLF ENYQEEYDIC
260 270 280 290 300
FTKDLNVYNP MSEIGKIVEY MAAIFLPLQP ATKVQREVIP PMNRAFDEED
310 320 330 340 350
IHTFVQMVEK YNEIVLSVTR QETIDHLSTV KRIPSIFIHD FLHMVYTRSI
360 370 380 390 400
FPQCRRLKQY EAFSNYVYGE LLPGFLTEAF VKCQLNPNQL FMDLGSGVGN
410 420 430 440 450
CVVQAALECG CGLSFGCEIM PNASDLTEAQ YKELVQRCKL FGLKLPSIEY
460 470 480 490 500
SLRQSFIDNK RVDELIPQCD VLLINNFLFD SDMNLQVEKL IQNAKVGCKI
510 520 530 540 550
ITLKNLRASG YTINFYNLES ILNRLRVERF ELKEDSVSWT HSGGEYYIST
560 570
VMETMDESLF DPSLRQRSTR RPTRYTR
Length:577
Mass (Da):66,134
Last modified:July 28, 2009 - v1
Checksum:i39EF7652FA801FD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928176 Genomic DNA. Translation: CAR28074.1.
RefSeqiXP_002497007.1. XM_002496962.1.

Genome annotation databases

GeneIDi8204269.
KEGGizro:ZYRO0D13200g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928176 Genomic DNA. Translation: CAR28074.1 .
RefSeqi XP_002497007.1. XM_002496962.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 559307.ZYRO0D13200g.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8204269.
KEGGi zro:ZYRO0D13200g.

Phylogenomic databases

eggNOGi NOG294902.
HOGENOMi HOG000112251.
InParanoidi C5DWA5.
KOi K11427.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229Imported.

Entry informationi

Entry nameiC5DWA5_ZYGRC
AccessioniPrimary (citable) accession number: C5DWA5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3