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C5DT72 (KEX1_ZYGRC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
Ordered Locus Names:ZYRO0C06006g
OrganismZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii) [Complete proteome]
Taxonomic identifier559307 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 684668Pheromone-processing carboxypeptidase KEX1
PRO_0000411957

Regions

Topological domain17 – 588572Lumenal Potential
Transmembrane589 – 60921Helical; Potential
Topological domain610 – 68475Cytoplasmic Potential
Compositional bias514 – 5218Poly-Glu

Sites

Active site1811 By similarity
Active site3901 By similarity
Active site4541 By similarity

Amino acid modifications

Glycosylation4431N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5DT72 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: BDC4CF4CFF0A311E

FASTA68478,284
        10         20         30         40         50         60 
MRFWYFSAIL WVVCQALPSK KQYSVAPELL PGLSEIEDKS TIPEMYAGHM PLAQSNSDDK 

        70         80         90        100        110        120 
DEIDYFFWKF SRPDKVLNTL IIWLNGGPGC SSMDGALVEN GPFRVNKDLK LVVNEGSWHT 

       130        140        150        160        170        180 
RADMLYVDQP VNTGFSVSNS KEKKYDEDLT LTTQHFMDFL ESYFKVFPDD QFKDLIIAGE 

       190        200        210        220        230        240 
SYSGQYVPFL AEAIQKRNAE TSDDLAKYNL RGILVGNGWM DPDTQSLAYL PFALSKGLID 

       250        260        270        280        290        300 
QNNPHFSTLL RQQEKCQDRI ISRNPNEHQP FQYEECENIL QSILTATRDV SADTPSNQVC 

       310        320        330        340        350        360 
MNIYSYNLRD SYPACGSNWP DEVLHVPGFF DRPGILEALN LDPSKVPQWK ECNLEVYYHL 

       370        380        390        400        410        420 
KNRKAVPSVR KLPALLDSGL KVILYNGEMD LLCNERGVLD MIDKLQWGGA KGFSSKTKEY 

       430        440        450        460        470        480 
DWNYRDFETN TDHIAGNVLH DRNLTYISVH NASHMVPNDK SLYSRGVVDI YLDDIFLEEL 

       490        500        510        520        530        540 
HGKDVLVTTS EKDMDDFDNS KLGVLGITDG KPSEEEELEE EFDQYVDELE EGESESGLLD 

       550        560        570        580        590        600 
DDKEDETVGA TDQNDDKNKG GEDKPNENPD KEKEEQDRQR KRRKGTFKIF GITILVVLTL 

       610        620        630        640        650        660 
GSFVFYIYIR KHTNKTRAIL IDPSRRQHDS QNKRVSWADD LEHGYDFETD QSQPRSGQSA 

       670        680 
PKKNGSYTRV PNTELDESFE LENL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU928175 Genomic DNA. Translation: CAR26983.1.
RefSeqXP_002495916.1. XM_002495871.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING559307.ZYRO0C06006g.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8203117.
KEGGzro:ZYRO0C06006g.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000208879.
KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_ZYGRC
AccessionPrimary (citable) accession number: C5DT72
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries