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C5DT72

- KEX1_ZYGRC

UniProt

C5DT72 - KEX1_ZYGRC

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811PROSITE-ProRule annotation
Active sitei390 – 3901PROSITE-ProRule annotation
Active sitei454 – 4541PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:ZYRO0C06006g
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
ProteomesiUP000008536: Chromosome C

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 588572LumenalSequence AnalysisAdd
BLAST
Transmembranei589 – 60921HelicalSequence AnalysisAdd
BLAST
Topological domaini610 – 68475CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 684668Pheromone-processing carboxypeptidase KEX1PRO_0000411957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi559307.ZYRO0C06006g.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi514 – 5218Poly-Glu

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000208879.
InParanoidiC5DT72.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5DT72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFWYFSAIL WVVCQALPSK KQYSVAPELL PGLSEIEDKS TIPEMYAGHM
60 70 80 90 100
PLAQSNSDDK DEIDYFFWKF SRPDKVLNTL IIWLNGGPGC SSMDGALVEN
110 120 130 140 150
GPFRVNKDLK LVVNEGSWHT RADMLYVDQP VNTGFSVSNS KEKKYDEDLT
160 170 180 190 200
LTTQHFMDFL ESYFKVFPDD QFKDLIIAGE SYSGQYVPFL AEAIQKRNAE
210 220 230 240 250
TSDDLAKYNL RGILVGNGWM DPDTQSLAYL PFALSKGLID QNNPHFSTLL
260 270 280 290 300
RQQEKCQDRI ISRNPNEHQP FQYEECENIL QSILTATRDV SADTPSNQVC
310 320 330 340 350
MNIYSYNLRD SYPACGSNWP DEVLHVPGFF DRPGILEALN LDPSKVPQWK
360 370 380 390 400
ECNLEVYYHL KNRKAVPSVR KLPALLDSGL KVILYNGEMD LLCNERGVLD
410 420 430 440 450
MIDKLQWGGA KGFSSKTKEY DWNYRDFETN TDHIAGNVLH DRNLTYISVH
460 470 480 490 500
NASHMVPNDK SLYSRGVVDI YLDDIFLEEL HGKDVLVTTS EKDMDDFDNS
510 520 530 540 550
KLGVLGITDG KPSEEEELEE EFDQYVDELE EGESESGLLD DDKEDETVGA
560 570 580 590 600
TDQNDDKNKG GEDKPNENPD KEKEEQDRQR KRRKGTFKIF GITILVVLTL
610 620 630 640 650
GSFVFYIYIR KHTNKTRAIL IDPSRRQHDS QNKRVSWADD LEHGYDFETD
660 670 680
QSQPRSGQSA PKKNGSYTRV PNTELDESFE LENL
Length:684
Mass (Da):78,284
Last modified:July 28, 2009 - v1
Checksum:iBDC4CF4CFF0A311E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928175 Genomic DNA. Translation: CAR26983.1.
RefSeqiXP_002495916.1. XM_002495871.1.

Genome annotation databases

GeneIDi8203117.
KEGGizro:ZYRO0C06006g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928175 Genomic DNA. Translation: CAR26983.1 .
RefSeqi XP_002495916.1. XM_002495871.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 559307.ZYRO0C06006g.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8203117.
KEGGi zro:ZYRO0C06006g.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000208879.
InParanoidi C5DT72.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229.

Entry informationi

Entry nameiKEX1_ZYGRC
AccessioniPrimary (citable) accession number: C5DT72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3