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C5DT72

- KEX1_ZYGRC

UniProt

C5DT72 - KEX1_ZYGRC

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, ZYRO0C06006g
Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811 By similarity
Active sitei390 – 3901 By similarity
Active sitei454 – 4541 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:ZYRO0C06006g
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
ProteomesiUP000008536: Chromosome C

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 588572Lumenal Reviewed prediction
Add
BLAST
Transmembranei589 – 60921Helical; Reviewed prediction
Add
BLAST
Topological domaini610 – 68475Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 684668Pheromone-processing carboxypeptidase KEX1
PRO_0000411957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi451 – 4511N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi559307.ZYRO0C06006g.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi514 – 5218Poly-Glu

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000208879.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C5DT72-1 [UniParc]FASTAAdd to Basket

« Hide

MRFWYFSAIL WVVCQALPSK KQYSVAPELL PGLSEIEDKS TIPEMYAGHM    50
PLAQSNSDDK DEIDYFFWKF SRPDKVLNTL IIWLNGGPGC SSMDGALVEN 100
GPFRVNKDLK LVVNEGSWHT RADMLYVDQP VNTGFSVSNS KEKKYDEDLT 150
LTTQHFMDFL ESYFKVFPDD QFKDLIIAGE SYSGQYVPFL AEAIQKRNAE 200
TSDDLAKYNL RGILVGNGWM DPDTQSLAYL PFALSKGLID QNNPHFSTLL 250
RQQEKCQDRI ISRNPNEHQP FQYEECENIL QSILTATRDV SADTPSNQVC 300
MNIYSYNLRD SYPACGSNWP DEVLHVPGFF DRPGILEALN LDPSKVPQWK 350
ECNLEVYYHL KNRKAVPSVR KLPALLDSGL KVILYNGEMD LLCNERGVLD 400
MIDKLQWGGA KGFSSKTKEY DWNYRDFETN TDHIAGNVLH DRNLTYISVH 450
NASHMVPNDK SLYSRGVVDI YLDDIFLEEL HGKDVLVTTS EKDMDDFDNS 500
KLGVLGITDG KPSEEEELEE EFDQYVDELE EGESESGLLD DDKEDETVGA 550
TDQNDDKNKG GEDKPNENPD KEKEEQDRQR KRRKGTFKIF GITILVVLTL 600
GSFVFYIYIR KHTNKTRAIL IDPSRRQHDS QNKRVSWADD LEHGYDFETD 650
QSQPRSGQSA PKKNGSYTRV PNTELDESFE LENL 684
Length:684
Mass (Da):78,284
Last modified:July 28, 2009 - v1
Checksum:iBDC4CF4CFF0A311E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928175 Genomic DNA. Translation: CAR26983.1.
RefSeqiXP_002495916.1. XM_002495871.1.

Genome annotation databases

GeneIDi8203117.
KEGGizro:ZYRO0C06006g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928175 Genomic DNA. Translation: CAR26983.1 .
RefSeqi XP_002495916.1. XM_002495871.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 559307.ZYRO0C06006g.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8203117.
KEGGi zro:ZYRO0C06006g.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000208879.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229.

Entry informationi

Entry nameiKEX1_ZYGRC
AccessioniPrimary (citable) accession number: C5DT72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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