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Protein

Hydroxymethylglutaryl-CoA synthase

Gene

ZYRO0A00770g

Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.UniRule annotation

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylglutaryl-CoA synthase (ZYRO0A00770g)
  3. 3-hydroxy-3-methylglutaryl coenzyme A reductase (ZYRO0B14696g)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism

Enzyme and pathway databases

UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthaseUniRule annotation (EC:2.3.3.10UniRule annotation)
Short name:
HMG-CoA synthaseUniRule annotation
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthaseUniRule annotation
Gene namesi
Ordered Locus Names:ZYRO0A00770gImported
OrganismiZygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)Imported
Taxonomic identifieri559307 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces
Proteomesi
  • UP000008536 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi4956.XP_002494408.1.

Structurei

3D structure databases

ProteinModelPortaliC5DP64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 186HMG_CoA_synt_NInterPro annotationAdd BLAST172
Domaini187 – 460HMG_CoA_synt_CInterPro annotationAdd BLAST274

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000012351.
InParanoidiC5DP64.
KOiK01641.
OrthoDBiEOG092C22BG.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
PfamiView protein in Pfam
PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

C5DP64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETKKQKTV QHPGKPQNVG IKGIEIYIPS QCVSQEELEK KDGVSAGKYT
60 70 80 90 100
IGLGQTKMSY VNDREDIYSM SLTVCSRLLK NYGIDPHSVG RLEVGTETLL
110 120 130 140 150
DKAKAVKTVL TQLFEGNNDL EGIDTYNACY GGTNALFNSI NWIESNAWDG
160 170 180 190 200
RDAIVVCGDI AIYDKGAARP TGGAGTVALW IGPDAPLVFD NVRASYMEHA
210 220 230 240 250
YDFYKPDFTS EYPYVDGHFS LTCYVKAVDQ VYRSYSKKAI ARGLAKDPLS
260 270 280 290 300
PESIGVKNHF DYNIFHVPTC KLVTKSYARL LYDDFRAKPE LYPEVDSNLA
310 320 330 340 350
KVDYEKSLTD KSIEKTFVGA TKQLCQERVQ PSLIVPTNTG NMYTGSLYAS
360 370 380 390 400
LASLLYYVGS EKLQGKRVGL FSYGSGLAAS LFSLKVVGDV SHINKLLDLD
410 420 430 440 450
NKLNSRAVET PEQYEAAIHL REEAHLKKSF EPKGSIDLVA PGAYYLTSID
460
DKFRRNYSVK Q
Length:461
Mass (Da):51,176
Last modified:July 28, 2009 - v1
Checksum:i3338229EB34399C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928173 Genomic DNA. Translation: CAR25475.1.
RefSeqiXP_002494408.1. XM_002494363.1.

Genome annotation databases

EnsemblFungiiCAR25475; CAR25475; ZYRO0A00770g.
GeneIDi8201808.
KEGGizro:ZYRO0A00770g.

Similar proteinsi

Entry informationi

Entry nameiC5DP64_ZYGRC
AccessioniPrimary (citable) accession number: C5DP64
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: August 30, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported