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Protein

L-lactate dehydrogenase

Gene

KLTH0G19536g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (KLTH0G19558g), L-lactate dehydrogenase (KLTH0G19536g), L-lactate dehydrogenase (KLTH0D00440g)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei189Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0G19536gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome G

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi381046.XP_002555876.1.

Structurei

3D structure databases

ProteinModelPortaliC5DNS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 156Ldh_1_NInterPro annotationAdd BLAST139
Domaini159 – 320Ldh_1_CInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793.
InParanoidiC5DNS8.
KOiK00016.
OrthoDBiEOG092C3G32.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

C5DNS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSIYPPAS TIKKVNPVKV AVIGVGSVGS TTAYTLLFSE MISEVVLIDI
60 70 80 90 100
NTHKAEGESM DLNHAAPSTT GSVVYVGDYS DCADAAIVII TGGANQKPGQ
110 120 130 140 150
TRMDLAATNA RILQGIIPKI VEYAPKTILL IATNPVDVLT YVSYKVSGFP
160 170 180 190 200
LNRVIGSGTL LDSARLKYHL SQHFKTSSKN VDAFIVGEHG DSSLPVWSHV
210 220 230 240 250
KISGIRLRDY CEQSQQAYDH ELFHQMFEKT RNAAYDIIER KGYTAYGIAA
260 270 280 290 300
GILRIVETIL KDGGSPLTVS TVGNYFGIEQ VALSVPTKLN RNGAHSPVDL
310 320
SFDIKEIELI KKSALQIKSV CSTLELL
Length:327
Mass (Da):35,409
Last modified:July 28, 2009 - v1
Checksum:iAD3A4D6BB8B0EB3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928171 Genomic DNA. Translation: CAR25439.1.
RefSeqiXP_002555876.1. XM_002555830.1.

Genome annotation databases

EnsemblFungiiCAR25439; CAR25439; KLTH0G19536g.
GeneIDi8294172.
KEGGilth:KLTH0G19536g.

Similar proteinsi

Entry informationi

Entry nameiC5DNS8_LACTC
AccessioniPrimary (citable) accession number: C5DNS8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported