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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

KLTH0G07480g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (KLTH0G07480g), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (KLTH0E05742g)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0G07480gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi381046.XP_002555363.1

Structurei

3D structure databases

ProteinModelPortaliC5DMB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 447FAD_binding_2InterPro annotationAdd BLAST396
Domaini502 – 636Succ_DH_flav_CInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

HOGENOMiHOG000160475
InParanoidiC5DMB5
KOiK00234
OrthoDBiEOG092C17LB

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

C5DMB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVRQMKLS TSRRLFSRTS RALRAFAANG DVDGQNSAPF GGQYQVVDHE
60 70 80 90 100
YDCLVVGAGG AGLRAAFGLA EAGYKTACIS KLFPTRSHTV AAQGGINAAL
110 120 130 140 150
GNMHKDNWKW HMYDTVKGSD WLGDQDSIHY MTREAADSII ELEHFGVPFS
160 170 180 190 200
RTEEGRIYQR AFGGQTKENG KGGQAYRTCA VADRTGHALL HTLYGQALRH
210 220 230 240 250
NTHFFIEYFA LDLLVHNGEV VGVIAYNQED GTIHRFRAHK TVIATGGYGR
260 270 280 290 300
AYFSCTSAHT CTGDGNAMVS RAGFPLQDLE FVQFHPSGIY GSGCLITEGA
310 320 330 340 350
RGEGGFLVNS EGERFMERYA PTAKDLACRD VVSRAITMEI REGRGVGPEK
360 370 380 390 400
DHMYLQLNHL PASVLKERLP GISETAAIFA GVDVTKEPIP ILPTVHYNMG
410 420 430 440 450
GIPTKWTGEA LTVDEEGNDQ VIPGLMACGE AACVSVHGAN RLGANSLLDL
460 470 480 490 500
VVFGRAVAHT VADTLQPGLP HKPLPSDLGK ESIANLDKLR NATGSKPTSQ
510 520 530 540 550
IRLAMQKAMQ ADVSVFRTQE SLDEGVRNVG AIDESFEDVG TTDRSMIWNS
560 570 580 590 600
DMVETLELQN LLSNARQTAV SAANRKESRG AHAREDYPER DDKEWMKHTL
610 620 630
SWQKHPQGNV ELGYRSVIAT TLDESECPPV LPTVRAY
Length:637
Mass (Da):69,516
Last modified:July 28, 2009 - v1
Checksum:i121EB6909E23B5C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928171 Genomic DNA Translation: CAR24926.1
RefSeqiXP_002555363.1, XM_002555317.1

Genome annotation databases

EnsemblFungiiCAR24926; CAR24926; KLTH0G07480g
GeneIDi8293633
KEGGilth:KLTH0G07480g

Entry informationi

Entry nameiC5DMB5_LACTC
AccessioniPrimary (citable) accession number: C5DMB5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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