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C5DLM9 (KEX1_LACTC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
Ordered Locus Names:KLTH0G01980g
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) [Complete proteome]
Taxonomic identifier559295 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4747 Potential
Chain48 – 745698Pheromone-processing carboxypeptidase KEX1
PRO_0000411922

Regions

Topological domain48 – 655608Lumenal Potential
Transmembrane656 – 67621Helical; Potential
Topological domain677 – 74569Cytoplasmic Potential
Compositional bias497 – 648152Asp-rich

Sites

Active site2141 By similarity
Active site4181 By similarity
Active site4821 By similarity

Amino acid modifications

Glycosylation4711N-linked (GlcNAc...) Potential
Glycosylation4791N-linked (GlcNAc...) Potential
Glycosylation5521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C5DLM9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: ECAC755742FE5B2E

FASTA74582,855
        10         20         30         40         50         60 
MSHFKYRNQT TDICNAAALD AFAMYSNYSV PLALLFALLL SFQTARALKA ADEYAVSPDL 

        70         80         90        100        110        120 
IPGLSQAEDR ALVPTMHAGH IPLDENNDEH TKNYFFWKFH DESGSASGPA RDTLIFWLNG 

       130        140        150        160        170        180 
GPGCSSMDGA LMESGALRID SDGKAYLNRG GWHTRGDIVF VDQPAGTGFS TVASDNDYDN 

       190        200        210        220        230        240 
DLKVVSEHFV AFLRNYFQVF PDDAGKQVVF AGESYAGQFI PYFARAVLDQ DEVQVNLQAL 

       250        260        270        280        290        300 
LIGNGWIDPN QQSLYYIPFA VEKGLITQDD PSFSYLLKQQ ENCQNKINSK ENDRFSFKEC 

       310        320        330        340        350        360 
ENILNNLLEV TRKIKDSEGK KVPSDQQCIN MYDLRLKDSY PSCGMNWPQD LPNLGKFFGT 

       370        380        390        400        410        420 
EGVLEALHLD PEHVSQWHEC DDKVSNYLKN PDSRASAAIL PGLLEAGLEV MLFNGDQDII 

       430        440        450        460        470        480 
CNNMGVEAVI SQMSWGGETG FSENVQLYDW VYRSPENSEI TPAGFVKYDR NLTFMSVYNA 

       490        500        510        520        530        540 
SHMVPFDNAL VSRGVVDLFL NDVDLVQIDG RDTLITDDVN KGKDGDASET DDTTELDCEG 

       550        560        570        580        590        600 
KDKLSEECKQ LNASKGQNGE SDKDEGEKGN EEDDNDDTED GKKDAGDEKD DGEKDDDEKD 

       610        620        630        640        650        660 
GDEKDGDEKD EEDDDDKDEN EKDEEDDDKD GDKPEGKNND GAEDEDDDHN SGSHLAVTMI 

       670        680        690        700        710        720 
CLLVSGTIIG GLYFTFRDRF RPRLRAILVD PTNRSEASKK TVSWAADLEQ DAADLSNPEN 

       730        740 
GAKKKGPYTS VPTQESRDSF ELDNL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU928171 Genomic DNA. Translation: CAR24690.1.
RefSeqXP_002555127.1. XM_002555081.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING559295.KLTH0G01980g.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8293386.
KEGGlth:KLTH0G01980g.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000208879.
KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
ProtoNetSearch...

Entry information

Entry nameKEX1_LACTC
AccessionPrimary (citable) accession number: C5DLM9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries