Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C5DLM9

- KEX1_LACTC

UniProt

C5DLM9 - KEX1_LACTC

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei214 – 2141By similarity
    Active sitei418 – 4181By similarity
    Active sitei482 – 4821By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    Ordered Locus Names:KLTH0G01980g
    OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
    Taxonomic identifieri559295 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
    ProteomesiUP000002036: Chromosome G

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4747Sequence AnalysisAdd
    BLAST
    Chaini48 – 745698Pheromone-processing carboxypeptidase KEX1PRO_0000411922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi552 – 5521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi559295.KLTH0G01980g.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini48 – 655608LumenalSequence AnalysisAdd
    BLAST
    Topological domaini677 – 74569CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei656 – 67621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi497 – 648152Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000208879.
    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C5DLM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHFKYRNQT TDICNAAALD AFAMYSNYSV PLALLFALLL SFQTARALKA    50
    ADEYAVSPDL IPGLSQAEDR ALVPTMHAGH IPLDENNDEH TKNYFFWKFH 100
    DESGSASGPA RDTLIFWLNG GPGCSSMDGA LMESGALRID SDGKAYLNRG 150
    GWHTRGDIVF VDQPAGTGFS TVASDNDYDN DLKVVSEHFV AFLRNYFQVF 200
    PDDAGKQVVF AGESYAGQFI PYFARAVLDQ DEVQVNLQAL LIGNGWIDPN 250
    QQSLYYIPFA VEKGLITQDD PSFSYLLKQQ ENCQNKINSK ENDRFSFKEC 300
    ENILNNLLEV TRKIKDSEGK KVPSDQQCIN MYDLRLKDSY PSCGMNWPQD 350
    LPNLGKFFGT EGVLEALHLD PEHVSQWHEC DDKVSNYLKN PDSRASAAIL 400
    PGLLEAGLEV MLFNGDQDII CNNMGVEAVI SQMSWGGETG FSENVQLYDW 450
    VYRSPENSEI TPAGFVKYDR NLTFMSVYNA SHMVPFDNAL VSRGVVDLFL 500
    NDVDLVQIDG RDTLITDDVN KGKDGDASET DDTTELDCEG KDKLSEECKQ 550
    LNASKGQNGE SDKDEGEKGN EEDDNDDTED GKKDAGDEKD DGEKDDDEKD 600
    GDEKDGDEKD EEDDDDKDEN EKDEEDDDKD GDKPEGKNND GAEDEDDDHN 650
    SGSHLAVTMI CLLVSGTIIG GLYFTFRDRF RPRLRAILVD PTNRSEASKK 700
    TVSWAADLEQ DAADLSNPEN GAKKKGPYTS VPTQESRDSF ELDNL 745
    Length:745
    Mass (Da):82,855
    Last modified:July 28, 2009 - v1
    Checksum:iECAC755742FE5B2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928171 Genomic DNA. Translation: CAR24690.1.
    RefSeqiXP_002555127.1. XM_002555081.1.

    Genome annotation databases

    GeneIDi8293386.
    KEGGilth:KLTH0G01980g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928171 Genomic DNA. Translation: CAR24690.1 .
    RefSeqi XP_002555127.1. XM_002555081.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 559295.KLTH0G01980g.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8293386.
    KEGGi lth:KLTH0G01980g.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000208879.
    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of protoploid Saccharomycetaceae."
      The Genolevures Consortium
      Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
      , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
      Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284.

    Entry informationi

    Entry nameiKEX1_LACTC
    AccessioniPrimary (citable) accession number: C5DLM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3