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Protein

Histone-lysine N-methyltransferase

Gene

KLTH0F04510g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Ordered Locus Names:KLTH0F04510gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
ProteomesiUP000002036 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000248214.
InParanoidiC5DKG6.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DKG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSSTASST RSQTPDDKHK LFFDYADKTQ EALSTFTELK KCSYASKELG
60 70 80 90 100
NSNSHDFIEC DCYEEFQDGV NHACGEDSDC INRLTLIECV NDLCGSCGND
110 120 130 140 150
CRNQRFQKRE YADIAVFQTQ KKGYGVRAQK DIEAHEFIYE YIGEVIAEDE
160 170 180 190 200
FRDRMIDYDH RGLKHFYFMM LQTGEFIDAT VKGSLARFCN HSCNPNAYVN
210 220 230 240 250
KWAVAGKLRM GIFANRKILK GEEITFDYNV DRYGATAQPC YCDEPNCLGF
260 270 280 290 300
LGGKTQTDAA SLLPQNYADA LGVRPSIEKK WIKLMKANGE KILKSEVNNI
310 320 330 340 350
NVEFVKSLDL SPCESLDDVS KVMSVLLQAD DNLIIRRLME RILLTKDQTM
360 370 380 390 400
HYQIIKLHGY RCFNKLLGIF EDDSEIQLEI LEYLNCLPKT TKNGIISSQI
410 420 430 440 450
DKKVEELKEK PELTQVSDEL LAKWRSFETY KRITKKDISE SSHKKMDLRR
460 470 480 490 500
LRLPPGWEII HENGKPVYYN AQQQTKLHHP PNGVTKTFGG SQPSRPSTPL
510 520 530 540 550
DSPSNGAISS KKRPLDAEEY EKKKKQRIEF QRKELERLKN EELQQLKDKL
560 570 580 590 600
ELEDQKKTEL EKIIAEANQQ KELEKQQKFK EQQEEEQKRQ KKLQQSKGDY
610 620 630 640 650
MLHKWNRFFA GFVPNLVRHY EKDLGKDHIK ECARDIVKTL SSKELKKDPK
660 670 680
KSPPPEPSKE KKAKVREFTK VYMEKFSQKY AQRKKK
Length:686
Mass (Da):79,600
Last modified:July 28, 2009 - v1
Checksum:iEFABF9B1ED935390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928170 Genomic DNA. Translation: CAR23967.1.
RefSeqiXP_002554404.1. XM_002554358.1.

Genome annotation databases

GeneIDi8292599.
KEGGilth:KLTH0F04510g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928170 Genomic DNA. Translation: CAR23967.1.
RefSeqiXP_002554404.1. XM_002554358.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8292599.
KEGGilth:KLTH0F04510g.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000248214.
InParanoidiC5DKG6.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Genolevures Consortium, Souciet J.L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B.
    , Val M.E., Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.F., Sacerdot C., Straub M.L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284Imported.

Entry informationi

Entry nameiC5DKG6_LACTC
AccessioniPrimary (citable) accession number: C5DKG6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.