Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase

Gene

KLTH0F04510g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Ordered Locus Names:KLTH0F04510gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi381046.XP_002554404.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 110AWSInterPro annotationAdd BLAST56
Domaini112 – 229SETInterPro annotationAdd BLAST118
Domaini236 – 252Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 596Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000248214
InParanoidiC5DKG6
KOiK11423
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di1.10.1740.100, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR038190 SRI_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

C5DKG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSSTASST RSQTPDDKHK LFFDYADKTQ EALSTFTELK KCSYASKELG
60 70 80 90 100
NSNSHDFIEC DCYEEFQDGV NHACGEDSDC INRLTLIECV NDLCGSCGND
110 120 130 140 150
CRNQRFQKRE YADIAVFQTQ KKGYGVRAQK DIEAHEFIYE YIGEVIAEDE
160 170 180 190 200
FRDRMIDYDH RGLKHFYFMM LQTGEFIDAT VKGSLARFCN HSCNPNAYVN
210 220 230 240 250
KWAVAGKLRM GIFANRKILK GEEITFDYNV DRYGATAQPC YCDEPNCLGF
260 270 280 290 300
LGGKTQTDAA SLLPQNYADA LGVRPSIEKK WIKLMKANGE KILKSEVNNI
310 320 330 340 350
NVEFVKSLDL SPCESLDDVS KVMSVLLQAD DNLIIRRLME RILLTKDQTM
360 370 380 390 400
HYQIIKLHGY RCFNKLLGIF EDDSEIQLEI LEYLNCLPKT TKNGIISSQI
410 420 430 440 450
DKKVEELKEK PELTQVSDEL LAKWRSFETY KRITKKDISE SSHKKMDLRR
460 470 480 490 500
LRLPPGWEII HENGKPVYYN AQQQTKLHHP PNGVTKTFGG SQPSRPSTPL
510 520 530 540 550
DSPSNGAISS KKRPLDAEEY EKKKKQRIEF QRKELERLKN EELQQLKDKL
560 570 580 590 600
ELEDQKKTEL EKIIAEANQQ KELEKQQKFK EQQEEEQKRQ KKLQQSKGDY
610 620 630 640 650
MLHKWNRFFA GFVPNLVRHY EKDLGKDHIK ECARDIVKTL SSKELKKDPK
660 670 680
KSPPPEPSKE KKAKVREFTK VYMEKFSQKY AQRKKK
Length:686
Mass (Da):79,600
Last modified:July 28, 2009 - v1
Checksum:iEFABF9B1ED935390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928170 Genomic DNA Translation: CAR23967.1
RefSeqiXP_002554404.1, XM_002554358.1

Genome annotation databases

EnsemblFungiiCAR23967; CAR23967; KLTH0F04510g
GeneIDi8292599
KEGGilth:KLTH0F04510g

Similar proteinsi

Entry informationi

Entry nameiC5DKG6_LACTC
AccessioniPrimary (citable) accession number: C5DKG6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health