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Protein

Glutamate decarboxylase

Gene

KLTH0E14080g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0E14080gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
ProteomesiUP000002036 Componenti: Chromosome E

Interactioni

Protein-protein interaction databases

STRINGi559295.KLTH0E14080g.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiC5DIP3.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

C5DIP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHKHNPKHV HERSEHFGRS GDSLSNSYKL LSDDLQKIAL EGDSELQTKH
60 70 80 90 100
RSLGSSYTIP QTGLPSEAAY ELVHNELTLD GNPHLNLASF VSTTSTQTAR
110 120 130 140 150
RLIMENIEKN LADNDEYPQM IELTQRCISM LAQLWKCGKD TKPLGCATTG
160 170 180 190 200
SSEAIMLGGL AMKRQWEKKM KEAGKSTEKP NIIMSSAAQV ALEKFARYFD
210 220 230 240 250
VECRLVPVSH ESDHHLDAAK LWDYVDENTI GCYVILGTTY TGHLENVEEV
260 270 280 290 300
ADVLSQIEKQ NPGWGNTTIP IHVDGASGGF VVPFAFSEKQ MAAFKLARWG
310 320 330 340 350
FNHPRVVSIN TSGHKFGLTT PGLGWILWKD DEYLLPELRF KLTYLGGVEE
360 370 380 390 400
TFNLNFSRPG FQVIHQYYNF LTLGEKGYKS LFDKALFTAR TFSHALLESD
410 420 430 440 450
EFKGHFEVVS SIHERIDGGE SRLHDYMTEP ESFKPGVPLV AFKLSKQFHE
460 470 480 490 500
KYPEIPQALV SSLLRSHGWI VPNYPLPAST DGSDKWEVLR VVFRSEMSLD
510 520 530 540 550
LAQLLLSHIL RALRKLVKCY EGVAETADVD QRRDAIYRML LTLAEPEGAE
560
PSEEDAKKRR KNYRGTC
Length:567
Mass (Da):63,971
Last modified:July 27, 2009 - v1
Checksum:iF8B13256998B6F14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928169 Genomic DNA. Translation: CAR23654.1.
RefSeqiXP_002554091.1. XM_002554045.1.

Genome annotation databases

GeneIDi8292260.
KEGGilth:KLTH0E14080g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928169 Genomic DNA. Translation: CAR23654.1.
RefSeqiXP_002554091.1. XM_002554045.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi559295.KLTH0E14080g.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8292260.
KEGGilth:KLTH0E14080g.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiC5DIP3.
KOiK01580.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284Imported.

Entry informationi

Entry nameiC5DIP3_LACTC
AccessioniPrimary (citable) accession number: C5DIP3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2009
Last sequence update: July 27, 2009
Last modified: February 3, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.