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C5DEQ7

- C5DEQ7_LACTC

UniProt

C5DEQ7 - C5DEQ7_LACTC

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Protein

DNA ligase

Gene

KLTH0C11286g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0C11286gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
ProteomesiUP000002036: Chromosome C

Interactioni

Protein-protein interaction databases

STRINGi559295.KLTH0C11286g.

Structurei

3D structure databases

ProteinModelPortaliC5DEQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000093622.
InParanoidiC5DEQ7.
KOiK10777.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DEQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGNGKCPSE TDTSKISENE PHNFAPSPDF RWLCEELFHR LDAINEHRQE
60 70 80 90 100
LGKAVTVKRV EIITCFIKLW RTTVGDDFFP ALRLMFPYRD PRAYHIKDFT
110 120 130 140 150
LIKAVCKALN LSRDSLTERR LLNWKQYAGR GTSLSKFCVQ EISKRRKEPL
160 170 180 190 200
PERQLTIDGL NEKLDELAKE ASGKKAWGTT GLSESHSFQF CLKNLSFLEL
210 220 230 240 250
RYFFDIVLKN RVIGGLEHKF LACWHPDAQI YLGVVTDLKI LSKKLWNPSV
260 270 280 290 300
RLDKRDLSIN IGHAFAPHLA KRLHVSYERI CSKLKHDFIL EEKMDGERIQ
310 320 330 340 350
LHYVNGGSVL KFLSRRGIDF SHLYGQEVAR GVISQYLKLK SDVRDCVLDG
360 370 380 390 400
EMVSYDKKRK IILPFGIVKS AAVDELINSE VGNENDGYRP LYMVFDLVYL
410 420 430 440 450
NGVSLTKVPL HIRKEYLKEI LSPVPDVVEI LKGIRACDAK AIKNFMQRAI
460 470 480 490 500
EMGSEGVIVK QASSTYEVGA RNDHWVKIKP EYFEDLGETM DLVVIGRDPG
510 520 530 540 550
KKDSLMCGLL VSDSEHILEN FGPIEHGKEG DPIIKCVSFC NVANGVSDEE
560 570 580 590 600
FKEINRKTRG SWVSYKEKPP PLSLLEFGSK IPVEWIDPKN SVVIEVKARS
610 620 630 640 650
VENSEYSSKR YRAGSTLHSA YCRRIRNDKD WTTCTSVAQY QQAKAAHNYH
660 670 680 690 700
RYKRKVHQVS PRRKRNVHEI FEYCAGEAKS ELDTEGSSIF EGLHFYILSD
710 720 730 740 750
YVTSQRRRYE RGMVAAKVVK HGGLIVKNID MRPEHLSYLR IVSGKTTIEC
760 770 780 790 800
RNLVNRGYDI IDPCWIFDCI SAGFQLGIEP KHCFQTSRRL LDNSRQRVDQ
810 820 830 840 850
YGDSFSRPLD TTEFQQLFKF FCSSPSDFSS RISSMLQDDL DEAPLFLLQR
860 870 880 890 900
FKIYVLAADL IPQQFSILRR KIELYGGVVS ETLEGANLVL VPSALSTART
910 920 930 940 950
AYYVQELRQK IAGNAFAGNT NTRIPHIVRS EWLDTCTTEQ CLVPEEDFSS

I
Length:951
Mass (Da):108,867
Last modified:July 28, 2009 - v1
Checksum:i6F40D1836C666F1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928167 Genomic DNA. Translation: CAR22268.1.
RefSeqiXP_002552706.1. XM_002552660.1.

Genome annotation databases

GeneIDi8291592.
KEGGilth:KLTH0C11286g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928167 Genomic DNA. Translation: CAR22268.1 .
RefSeqi XP_002552706.1. XM_002552660.1.

3D structure databases

ProteinModelPortali C5DEQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 559295.KLTH0C11286g.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8291592.
KEGGi lth:KLTH0C11286g.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000093622.
InParanoidi C5DEQ7.
KOi K10777.
OrthoDBi EOG7QC84G.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
PANTHERi PTHR10459:SF7. PTHR10459:SF7. 1 hit.
Pfami PF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284Imported.

Entry informationi

Entry nameiC5DEQ7_LACTC
AccessioniPrimary (citable) accession number: C5DEQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3