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C5DCR8

- C5DCR8_LACTC

UniProt

C5DCR8 - C5DCR8_LACTC

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

KLTH0B05280g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0B05280gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
ProteomesiUP000002036: Chromosome B

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi559295.KLTH0B05280g.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000066111.
InParanoidiC5DCR8.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DCR8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDYYGRGYD SPYQRYSRGH NGRRAGRRHG GRPPKRESHQ YGYSRRDEYL
60 70 80 90 100
HGETYFPPSS RMSKPVNAVV EPLRPKPQLR FNNDSFREKY HYFDPVSEKL
110 120 130 140 150
LHRDEMKSWA SEKLPKTGYV IVQDQSKDKT RAVMKPRCPD QKAVDPRSQS
160 170 180 190 200
SPSPESGVYR KRRNQLVSLP RLVYDKHSVG PPPPNEIVVY PVFRDHSSAV
210 220 230 240 250
QDIAIKNYFS TFGEISHFQS FNDPISALPL YVYVVRYTGP PGNLDAPFRA
260 270 280 290 300
AYKAAKTFEN SHYFVSGFKF AVSINRANYS QKIVDGFIQD NIKQAAKIKK
310 320 330 340 350
EVERQNSQKQ ISSGPQAKRL PRDLERVVNG RPSLLVLKRF ISIHGLTVED
360 370 380 390 400
FKIKLAKYKF SRVLNHSTGI YIVFNDISDA RACMFVENDV LAMPSKRRRT
410 420 430 440 450
PVKVRFSLIE SQPSIVATVK RDGLRDQKKT YASEEQLLET AADLIIDELG
460 470 480 490 500
RALDRDIKRR VIGPLVFDSL NPANYPAITA KKDEEEERKS EQRRVAAEQK
510 520 530 540 550
QDQQSKSASF DIFNLYGARF RKKNYIKSQI GEQSEPEYES KLKFSSSLKD
560 570 580 590 600
SGQEKPMAHL LNESSRSNTP LAAENFKSDD EQAQSAVEDD EDEEGFSDVS
610 620 630 640 650
ELPEKKIKTG SSEATTPETE SNKYVLNSSR IQELLRIPEK YRPDASEEPK
660 670 680 690 700
TIYPQDDFDS YEFSSVSLGD FQRAVKDEED FETLKNILNP PSSALSSNEE
710 720 730 740 750
YILHSLVHEV STEAEERHKV SKLQTSANEV PFDESLRSSA GSFKAGGFKK
760 770 780 790 800
IPDKLKNCYL PHRRKLHQPL NTVYNHQDTP EAVTDVHRNE SEKLDMDAHA
810 820 830 840 850
QEVSSSRVNR AINRRFQQDI EAQKAMIGSE SELLTLNQLT KRKKPVTFAR
860 870 880 890 900
SAIHNWGLYA LEPIAAKEMI IEYVGEILRQ PVAEMRERTY LKSGIGSSYL
910 920 930 940 950
FRVDESTVID ATKKGGIARF INHCCDPSCT AKIIRVGGRK RIVIYALRDI
960 970 980
AANEELTYDY KFERETDDEE RLPCFCGAPT CKGFLN
Length:986
Mass (Da):112,610
Last modified:July 28, 2009 - v1
Checksum:i0E91960FBF0F2422
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928166 Genomic DNA. Translation: CAR21579.1.
RefSeqiXP_002552017.1. XM_002551971.1.

Genome annotation databases

GeneIDi8290855.
KEGGilth:KLTH0B05280g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928166 Genomic DNA. Translation: CAR21579.1 .
RefSeqi XP_002552017.1. XM_002551971.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 559295.KLTH0B05280g.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8290855.
KEGGi lth:KLTH0B05280g.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000066111.
InParanoidi C5DCR8.
KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284Imported.

Entry informationi

Entry nameiC5DCR8_LACTC
AccessioniPrimary (citable) accession number: C5DCR8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3