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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

KLTH0B05280g

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0B05280gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
Proteomesi
  • UP000002036 Componenti: Chromosome B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi381046.XP_002552017.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini844 – 961SETInterPro annotationAdd BLAST118
Domaini970 – 986Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili288 – 308Sequence analysisAdd BLAST21
Coiled coili480 – 502Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000066111
InParanoidiC5DCR8
KOiK11422
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR017111 Set1
IPR024636 SET_assoc
IPR001214 SET_dom
PANTHERiPTHR22884:SF462 PTHR22884:SF462, 4 hits
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00856 SET, 1 hit
PF11767 SET_assoc, 1 hit
PIRSFiPIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 1 hit
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS51572 SAM_MT43_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

C5DCR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYYGRGYD SPYQRYSRGH NGRRAGRRHG GRPPKRESHQ YGYSRRDEYL
60 70 80 90 100
HGETYFPPSS RMSKPVNAVV EPLRPKPQLR FNNDSFREKY HYFDPVSEKL
110 120 130 140 150
LHRDEMKSWA SEKLPKTGYV IVQDQSKDKT RAVMKPRCPD QKAVDPRSQS
160 170 180 190 200
SPSPESGVYR KRRNQLVSLP RLVYDKHSVG PPPPNEIVVY PVFRDHSSAV
210 220 230 240 250
QDIAIKNYFS TFGEISHFQS FNDPISALPL YVYVVRYTGP PGNLDAPFRA
260 270 280 290 300
AYKAAKTFEN SHYFVSGFKF AVSINRANYS QKIVDGFIQD NIKQAAKIKK
310 320 330 340 350
EVERQNSQKQ ISSGPQAKRL PRDLERVVNG RPSLLVLKRF ISIHGLTVED
360 370 380 390 400
FKIKLAKYKF SRVLNHSTGI YIVFNDISDA RACMFVENDV LAMPSKRRRT
410 420 430 440 450
PVKVRFSLIE SQPSIVATVK RDGLRDQKKT YASEEQLLET AADLIIDELG
460 470 480 490 500
RALDRDIKRR VIGPLVFDSL NPANYPAITA KKDEEEERKS EQRRVAAEQK
510 520 530 540 550
QDQQSKSASF DIFNLYGARF RKKNYIKSQI GEQSEPEYES KLKFSSSLKD
560 570 580 590 600
SGQEKPMAHL LNESSRSNTP LAAENFKSDD EQAQSAVEDD EDEEGFSDVS
610 620 630 640 650
ELPEKKIKTG SSEATTPETE SNKYVLNSSR IQELLRIPEK YRPDASEEPK
660 670 680 690 700
TIYPQDDFDS YEFSSVSLGD FQRAVKDEED FETLKNILNP PSSALSSNEE
710 720 730 740 750
YILHSLVHEV STEAEERHKV SKLQTSANEV PFDESLRSSA GSFKAGGFKK
760 770 780 790 800
IPDKLKNCYL PHRRKLHQPL NTVYNHQDTP EAVTDVHRNE SEKLDMDAHA
810 820 830 840 850
QEVSSSRVNR AINRRFQQDI EAQKAMIGSE SELLTLNQLT KRKKPVTFAR
860 870 880 890 900
SAIHNWGLYA LEPIAAKEMI IEYVGEILRQ PVAEMRERTY LKSGIGSSYL
910 920 930 940 950
FRVDESTVID ATKKGGIARF INHCCDPSCT AKIIRVGGRK RIVIYALRDI
960 970 980
AANEELTYDY KFERETDDEE RLPCFCGAPT CKGFLN
Length:986
Mass (Da):112,610
Last modified:July 28, 2009 - v1
Checksum:i0E91960FBF0F2422
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928166 Genomic DNA Translation: CAR21579.1
RefSeqiXP_002552017.1, XM_002551971.1

Genome annotation databases

EnsemblFungiiCAR21579; CAR21579; KLTH0B05280g
GeneIDi8290855
KEGGilth:KLTH0B05280g

Similar proteinsi

Entry informationi

Entry nameiC5DCR8_LACTC
AccessioniPrimary (citable) accession number: C5DCR8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health