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C5DCR8 (C5DCR8_LACTC) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length986 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity. PIRNR PIRNR037104

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR037104 SAAS SAAS001214

Subunit structure

Component of the COMPASS (Set1C) complex By similarity. PIRNR PIRNR037104

Subcellular location

Nucleus By similarity PIRNR PIRNR037104.

Sequence similarities

Contains 1 SET domain. RuleBase RU004538

Contains SET domain. SAAS SAAS001214

Contains post-SET domain. SAAS SAAS001214

Sequences

Sequence LengthMass (Da)Tools
C5DCR8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 0E91960FBF0F2422

FASTA986112,610
        10         20         30         40         50         60 
MSDYYGRGYD SPYQRYSRGH NGRRAGRRHG GRPPKRESHQ YGYSRRDEYL HGETYFPPSS 

        70         80         90        100        110        120 
RMSKPVNAVV EPLRPKPQLR FNNDSFREKY HYFDPVSEKL LHRDEMKSWA SEKLPKTGYV 

       130        140        150        160        170        180 
IVQDQSKDKT RAVMKPRCPD QKAVDPRSQS SPSPESGVYR KRRNQLVSLP RLVYDKHSVG 

       190        200        210        220        230        240 
PPPPNEIVVY PVFRDHSSAV QDIAIKNYFS TFGEISHFQS FNDPISALPL YVYVVRYTGP 

       250        260        270        280        290        300 
PGNLDAPFRA AYKAAKTFEN SHYFVSGFKF AVSINRANYS QKIVDGFIQD NIKQAAKIKK 

       310        320        330        340        350        360 
EVERQNSQKQ ISSGPQAKRL PRDLERVVNG RPSLLVLKRF ISIHGLTVED FKIKLAKYKF 

       370        380        390        400        410        420 
SRVLNHSTGI YIVFNDISDA RACMFVENDV LAMPSKRRRT PVKVRFSLIE SQPSIVATVK 

       430        440        450        460        470        480 
RDGLRDQKKT YASEEQLLET AADLIIDELG RALDRDIKRR VIGPLVFDSL NPANYPAITA 

       490        500        510        520        530        540 
KKDEEEERKS EQRRVAAEQK QDQQSKSASF DIFNLYGARF RKKNYIKSQI GEQSEPEYES 

       550        560        570        580        590        600 
KLKFSSSLKD SGQEKPMAHL LNESSRSNTP LAAENFKSDD EQAQSAVEDD EDEEGFSDVS 

       610        620        630        640        650        660 
ELPEKKIKTG SSEATTPETE SNKYVLNSSR IQELLRIPEK YRPDASEEPK TIYPQDDFDS 

       670        680        690        700        710        720 
YEFSSVSLGD FQRAVKDEED FETLKNILNP PSSALSSNEE YILHSLVHEV STEAEERHKV 

       730        740        750        760        770        780 
SKLQTSANEV PFDESLRSSA GSFKAGGFKK IPDKLKNCYL PHRRKLHQPL NTVYNHQDTP 

       790        800        810        820        830        840 
EAVTDVHRNE SEKLDMDAHA QEVSSSRVNR AINRRFQQDI EAQKAMIGSE SELLTLNQLT 

       850        860        870        880        890        900 
KRKKPVTFAR SAIHNWGLYA LEPIAAKEMI IEYVGEILRQ PVAEMRERTY LKSGIGSSYL 

       910        920        930        940        950        960 
FRVDESTVID ATKKGGIARF INHCCDPSCT AKIIRVGGRK RIVIYALRDI AANEELTYDY 

       970        980 
KFERETDDEE RLPCFCGAPT CKGFLN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU928166 Genomic DNA. Translation: CAR21579.1.
RefSeqXP_002552017.1. XM_002551971.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING559295.KLTH0B05280g.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8290855.
KEGGlth:KLTH0B05280g.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000066111.
KOK11422.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5DCR8_LACTC
AccessionPrimary (citable) accession number: C5DCR8
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)