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C5DCR8

- C5DCR8_LACTC

UniProt

C5DCR8 - C5DCR8_LACTC

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene
KLTH0B05280g
Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Ordered Locus Names:KLTH0B05280gImported
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
ProteomesiUP000002036: Chromosome B

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi559295.KLTH0B05280g.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000066111.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5DCR8-1 [UniParc]FASTAAdd to Basket

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MSDYYGRGYD SPYQRYSRGH NGRRAGRRHG GRPPKRESHQ YGYSRRDEYL    50
HGETYFPPSS RMSKPVNAVV EPLRPKPQLR FNNDSFREKY HYFDPVSEKL 100
LHRDEMKSWA SEKLPKTGYV IVQDQSKDKT RAVMKPRCPD QKAVDPRSQS 150
SPSPESGVYR KRRNQLVSLP RLVYDKHSVG PPPPNEIVVY PVFRDHSSAV 200
QDIAIKNYFS TFGEISHFQS FNDPISALPL YVYVVRYTGP PGNLDAPFRA 250
AYKAAKTFEN SHYFVSGFKF AVSINRANYS QKIVDGFIQD NIKQAAKIKK 300
EVERQNSQKQ ISSGPQAKRL PRDLERVVNG RPSLLVLKRF ISIHGLTVED 350
FKIKLAKYKF SRVLNHSTGI YIVFNDISDA RACMFVENDV LAMPSKRRRT 400
PVKVRFSLIE SQPSIVATVK RDGLRDQKKT YASEEQLLET AADLIIDELG 450
RALDRDIKRR VIGPLVFDSL NPANYPAITA KKDEEEERKS EQRRVAAEQK 500
QDQQSKSASF DIFNLYGARF RKKNYIKSQI GEQSEPEYES KLKFSSSLKD 550
SGQEKPMAHL LNESSRSNTP LAAENFKSDD EQAQSAVEDD EDEEGFSDVS 600
ELPEKKIKTG SSEATTPETE SNKYVLNSSR IQELLRIPEK YRPDASEEPK 650
TIYPQDDFDS YEFSSVSLGD FQRAVKDEED FETLKNILNP PSSALSSNEE 700
YILHSLVHEV STEAEERHKV SKLQTSANEV PFDESLRSSA GSFKAGGFKK 750
IPDKLKNCYL PHRRKLHQPL NTVYNHQDTP EAVTDVHRNE SEKLDMDAHA 800
QEVSSSRVNR AINRRFQQDI EAQKAMIGSE SELLTLNQLT KRKKPVTFAR 850
SAIHNWGLYA LEPIAAKEMI IEYVGEILRQ PVAEMRERTY LKSGIGSSYL 900
FRVDESTVID ATKKGGIARF INHCCDPSCT AKIIRVGGRK RIVIYALRDI 950
AANEELTYDY KFERETDDEE RLPCFCGAPT CKGFLN 986
Length:986
Mass (Da):112,610
Last modified:July 28, 2009 - v1
Checksum:i0E91960FBF0F2422
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928166 Genomic DNA. Translation: CAR21579.1.
RefSeqiXP_002552017.1. XM_002551971.1.

Genome annotation databases

GeneIDi8290855.
KEGGilth:KLTH0B05280g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928166 Genomic DNA. Translation: CAR21579.1 .
RefSeqi XP_002552017.1. XM_002551971.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 559295.KLTH0B05280g.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8290855.
KEGGi lth:KLTH0B05280g.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000066111.
KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of protoploid Saccharomycetaceae."
    The Genolevures Consortium
    Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
    , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
    Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284.

Entry informationi

Entry nameiC5DCR8_LACTC
AccessioniPrimary (citable) accession number: C5DCR8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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