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C5DCR8

- C5DCR8_LACTC

UniProt

C5DCR8 - C5DCR8_LACTC

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Protein
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Gene
KLTH0B05280g
Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotations, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotations

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    Ordered Locus Names:KLTH0B05280gImported
    OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)Imported
    Taxonomic identifieri559295 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
    ProteomesiUP000002036: Chromosome B

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. Set1C/COMPASS complex Source: InterPro
    2. chromosome Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotations

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi559295.KLTH0B05280g.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotations
    Contains post-SET domain.SAAS annotations

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000066111.
    KOiK11422.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5DCR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDYYGRGYD SPYQRYSRGH NGRRAGRRHG GRPPKRESHQ YGYSRRDEYL    50
    HGETYFPPSS RMSKPVNAVV EPLRPKPQLR FNNDSFREKY HYFDPVSEKL 100
    LHRDEMKSWA SEKLPKTGYV IVQDQSKDKT RAVMKPRCPD QKAVDPRSQS 150
    SPSPESGVYR KRRNQLVSLP RLVYDKHSVG PPPPNEIVVY PVFRDHSSAV 200
    QDIAIKNYFS TFGEISHFQS FNDPISALPL YVYVVRYTGP PGNLDAPFRA 250
    AYKAAKTFEN SHYFVSGFKF AVSINRANYS QKIVDGFIQD NIKQAAKIKK 300
    EVERQNSQKQ ISSGPQAKRL PRDLERVVNG RPSLLVLKRF ISIHGLTVED 350
    FKIKLAKYKF SRVLNHSTGI YIVFNDISDA RACMFVENDV LAMPSKRRRT 400
    PVKVRFSLIE SQPSIVATVK RDGLRDQKKT YASEEQLLET AADLIIDELG 450
    RALDRDIKRR VIGPLVFDSL NPANYPAITA KKDEEEERKS EQRRVAAEQK 500
    QDQQSKSASF DIFNLYGARF RKKNYIKSQI GEQSEPEYES KLKFSSSLKD 550
    SGQEKPMAHL LNESSRSNTP LAAENFKSDD EQAQSAVEDD EDEEGFSDVS 600
    ELPEKKIKTG SSEATTPETE SNKYVLNSSR IQELLRIPEK YRPDASEEPK 650
    TIYPQDDFDS YEFSSVSLGD FQRAVKDEED FETLKNILNP PSSALSSNEE 700
    YILHSLVHEV STEAEERHKV SKLQTSANEV PFDESLRSSA GSFKAGGFKK 750
    IPDKLKNCYL PHRRKLHQPL NTVYNHQDTP EAVTDVHRNE SEKLDMDAHA 800
    QEVSSSRVNR AINRRFQQDI EAQKAMIGSE SELLTLNQLT KRKKPVTFAR 850
    SAIHNWGLYA LEPIAAKEMI IEYVGEILRQ PVAEMRERTY LKSGIGSSYL 900
    FRVDESTVID ATKKGGIARF INHCCDPSCT AKIIRVGGRK RIVIYALRDI 950
    AANEELTYDY KFERETDDEE RLPCFCGAPT CKGFLN 986
    Length:986
    Mass (Da):112,610
    Last modified:July 28, 2009 - v1
    Checksum:i0E91960FBF0F2422
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928166 Genomic DNA. Translation: CAR21579.1.
    RefSeqiXP_002552017.1. XM_002551971.1.

    Genome annotation databases

    GeneIDi8290855.
    KEGGilth:KLTH0B05280g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928166 Genomic DNA. Translation: CAR21579.1 .
    RefSeqi XP_002552017.1. XM_002551971.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 559295.KLTH0B05280g.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8290855.
    KEGGi lth:KLTH0B05280g.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000066111.
    KOi K11422.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of protoploid Saccharomycetaceae."
      The Genolevures Consortium
      Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V., Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V., Vacherie B., Val M.-E.
      , Fulton R.S., Minx P., Wilson R., Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.
      Genome Res. 19:1696-1709(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284.

    Entry informationi

    Entry nameiC5DCR8_LACTC
    AccessioniPrimary (citable) accession number: C5DCR8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: May 14, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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