ID   C5DBR6_LACTC            Unreviewed;       517 AA.
AC   C5DBR6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=KLTH0A04796p {ECO:0000313|EMBL:CAR21223.1};
GN   OrderedLocusNames=KLTH0A04796g {ECO:0000313|EMBL:CAR21223.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21223.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21223.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CU928165; CAR21223.1; -; Genomic_DNA.
DR   RefSeq; XP_002551665.1; XM_002551619.1.
DR   AlphaFoldDB; C5DBR6; -.
DR   STRING; 559295.C5DBR6; -.
DR   GeneID; 8290469; -.
DR   KEGG; lth:KLTH0A04796g; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_0_1_1; -.
DR   InParanoid; C5DBR6; -.
DR   OMA; WSNTFNK; -.
DR   OrthoDB; 216092at2759; -.
DR   Proteomes; UP000002036; Chromosome A.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR   CDD; cd07091; ALDH_F1-2_Ald2-like; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   DOMAIN          49..508
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        285
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   517 AA;  56411 MW;  F91701B32BB40F8E CRC64;
     MLVSRTFSRS VASRLVLRSY SQLPLRVPIT LPSGVTYDQP TGLFINGEFV PSRQHKTFEV
     LNPSTEQEIA HVYEAREDDV DVAVAAAKAA FENKWGTADP EFRSRCLYKL ADLVDKHAEV
     LAGIESLDNG KSLLCSRGDV DLVAKYLRSC AGWADKIFGR TIDTGSTHFS YTRREPLGVC
     AQIIPWNFPL LMWSWKLGPA LATGNTVVLK PAEATPLSAL YACQLVQEAG IPAGVVNILP
     GFGKLLGDRL CTHKDVKKIA FTGSTATGRH IMRSAANTIK KVTLELGGKS PNIVFGDADL
     DKAVRTIAFG IFYNSGEVCC AGSRVYVQDT VYEEVLEKFK NYAESLKVGD PFQEGVFQGA
     QTSQMQIDKI LDYVQIGTGE GARVVAGGER LGDKGYFIKP TIFADVTEDM RIVKEEIFGP
     VVTVSKFSTV DEVIEMANDS EYGLAAGIHT KDINKAMDVS NRVKAGTVWI NTYNSFHQSV
     PFGGFGQSGI GREMGAEALD NYTQVKAVRM AIDPAER
//