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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciGSP471223:GH2C-1639-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:GWCH70_1554
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000002386 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Cobalt-precorrin-5B C(1)-methyltransferasePRO_1000212938Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_1554.

Structurei

3D structure databases

ProteinModelPortaliC5DAN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiEOG6WX4M7.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

C5DAN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKKTLREG YTTGACATAA TKAALTALIT GIIQTEATIY LPVGRWATFA
60 70 80 90 100
IEACEIYGES VKATVIKDGG DDPDATHGAA IVSTVSWAEQ PGIHLDGGKG
110 120 130 140 150
VGRVTKPGLP VPVGEAAINP IPRKMIHETA REVLEQYGIS RGVNVIISVP
160 170 180 190 200
NGEEIAKKTL NARLGIIGGI SILGTRGIVI PFSTSAYRAS IIQAIQVAKA
210 220 230 240 250
NGCDHVVITT GGRSEKFAMR QYPHLPEEAF IEMGDFVGFT LKQCKRLGIR
260 270 280 290 300
TVSMVGMMGK FSKVAQGIMM VHSKSAPIDF SFLAAIAEQA GASPELVAAV
310 320 330 340 350
REANTASQVG EMMQEAGNER FFEILCDHCC LSALREVGGG MTVETSLYTM
360
GGQLLGKAVR NDAGD
Length:365
Mass (Da):38,544
Last modified:July 28, 2009 - v1
Checksum:i4FF8CD0C6A7D2256
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS24352.1.
RefSeqiWP_015863810.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS24352; ACS24352; GWCH70_1554.
KEGGigwc:GWCH70_1554.
PATRICi21972073. VBIGeoSp101709_1650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS24352.1.
RefSeqiWP_015863810.1. NC_012793.1.

3D structure databases

ProteinModelPortaliC5DAN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471223.GWCH70_1554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS24352; ACS24352; GWCH70_1554.
KEGGigwc:GWCH70_1554.
PATRICi21972073. VBIGeoSp101709_1650.

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiEOG6WX4M7.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciGSP471223:GH2C-1639-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiCBID_GEOSW
AccessioniPrimary (citable) accession number: C5DAN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: January 20, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.