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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciGSP471223:GH2C-1517-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:GWCH70_1433
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000002386 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Probable malate:quinone oxidoreductasePRO_1000204200Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_1433.

Structurei

3D structure databases

ProteinModelPortaliC5DAE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiEOG6X6R8Z.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

C5DAE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRQTSTDV ILIGAGIMSA TLGTLLKELA PEWEIKVFEK LGKPGEESSN
60 70 80 90 100
EWNNAGTGHA ALCELNYTPE KPDGSIDISK AIRINEQFQV SKQFWAYLVK
110 120 130 140 150
NNLLQNPQEF IRPLPHISLV QGENNVRFLK KRFEALSNNP LFQGMEFSDD
160 170 180 190 200
PEKLKEWMPL IMEGRTSNEP IAATKIDSGT DVNFGALTRM LFDHLKRKGV
210 220 230 240 250
EINYKHSVKD IKRTSDGLWE LKVKDLNSGS VEIHKAKFVF IGAGGGSLHL
260 270 280 290 300
LQKSGIPEGK HIGGFPVSGL FMVCNNPKVV EKHHAKVYGK AKIGAPPMSV
310 320 330 340 350
PHLDTRYIDN KKMLLFGPFA GFSPKFLKNG SNMDLFASVK LHNLGTLLAS
360 370 380 390 400
AFKNFSLEKY LIQQLMLTKE KRMEELREFV PTAKSEDWDI VIAGQRVQII
410 420 430 440 450
KDTEAGGKGT IQFGTEVVSA ADGSIAALLG ASPGASTAVH VMLEVLKKCF
460 470 480 490 500
PQHMKEWEPK IKEMIPSYGV SLAKNPDLFQ KLHDSTAETL GLNEKEPVSG

ASEKELVYS
Length:509
Mass (Da):56,362
Last modified:July 28, 2009 - v1
Checksum:i53728A62FC8BF4A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS24254.1.
RefSeqiWP_015863717.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS24254; ACS24254; GWCH70_1433.
KEGGigwc:GWCH70_1433.
PATRICi21971811. VBIGeoSp101709_1520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS24254.1.
RefSeqiWP_015863717.1. NC_012793.1.

3D structure databases

ProteinModelPortaliC5DAE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471223.GWCH70_1433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS24254; ACS24254; GWCH70_1433.
KEGGigwc:GWCH70_1433.
PATRICi21971811. VBIGeoSp101709_1520.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiEOG6X6R8Z.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciGSP471223:GH2C-1517-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiMQO_GEOSW
AccessioniPrimary (citable) accession number: C5DAE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: January 20, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.