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C5D975

- C5D975_GEOSW

UniProt

C5D975 - C5D975_GEOSW

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Protein
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Gene
murA, GWCH70_3288
Organism
Geobacillus sp. (strain WCH70)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton donor By similarityUniRule annotation

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotations, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

PyruvateUniRule annotation

Enzyme and pathway databases

BioCyciGSP471223:GH2C-3402-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Gene namesi
Name:murAUniRule annotation
Ordered Locus Names:GWCH70_3288Imported
OrganismiGeobacillus sp. (strain WCH70)Imported
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 11712-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_3288.

Structurei

3D structure databases

ProteinModelPortaliC5D975.

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiHGLEQMG.
OrthoDBiEOG68M4GK.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D975-1 [UniParc]FASTAAdd to Basket

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MEKIIVRGGN RLSGTVKVEG AKNAVLPVIA ATLLASNGKS VIHDVPALSD    50
VYTISEVLRY LGADVKIEEN TITVDASQEL KFEAPFEYVR KMRASVLVMG 100
SLLARNGRAR VALPGGCAIG SRPIDQHLKG FEAMGAHVKV GNGFIDAEVK 150
GRLRGAKIYL DFPSVGATEN IMMAAVLAEG TTIIENCAKE PEIVDLANFL 200
NAMGAKVRGA GTGTIRIEGV DQLTGTTHTV IPDRIEAGTF MVAAAITGGN 250
VLVQGAVPEH LSSLIAKMEE MGVTIIEEGN GLRVIGPEKL KAVDIKTMPY 300
PGFPTDMQSQ MMALLLKAEG TSMVTETVFE NRFMHVEEFR RMNADIKIEG 350
RSVIINGPCN LQGAEVAATD LRAAAALILA GLAAEGYTRV TELRHLDRGY 400
VRFHEKLAAL GADIERVNDE SETAAEDVKV KDLNI 435
Length:435
Mass (Da):46,549
Last modified:July 28, 2009 - v1
Checksum:iD9CBCB6895B29552
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25928.1.
RefSeqiWP_015865295.1. NC_012793.1.
YP_002951194.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25928; ACS25928; GWCH70_3288.
GeneIDi7977195.
KEGGigwc:GWCH70_3288.
PATRICi21975699. VBIGeoSp101709_3430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25928.1 .
RefSeqi WP_015865295.1. NC_012793.1.
YP_002951194.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D975.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_3288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS25928 ; ACS25928 ; GWCH70_3288 .
GeneIDi 7977195.
KEGGi gwc:GWCH70_3288.
PATRICi 21975699. VBIGeoSp101709_3430.

Phylogenomic databases

eggNOGi COG0766.
HOGENOMi HOG000075602.
KOi K00790.
OMAi HGLEQMG.
OrthoDBi EOG68M4GK.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci GSP471223:GH2C-3402-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00111. MurA.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view ]
PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01072. murA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70Imported.

Entry informationi

Entry nameiC5D975_GEOSW
AccessioniPrimary (citable) accession number: C5D975
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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