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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Geobacillus sp. (strain WCH70)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotationSAAS annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotationSAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93UDP-N-acetylglucosamineUniRule annotation1
Active sitei117Proton donorUniRule annotation1
Binding sitei306UDP-N-acetylglucosamineUniRule annotation1
Binding sitei328UDP-N-acetylglucosamine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandPyruvateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferaseUniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
Short name:
EPTUniRule annotation
Gene namesi
Name:murAUniRule annotation
Ordered Locus Names:GWCH70_3288Imported
OrganismiGeobacillus sp. (strain WCH70)Imported
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000002386 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1172-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_3288.

Structurei

3D structure databases

ProteinModelPortaliC5D975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 407EPSP_synthaseInterPro annotationAdd BLAST401

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 23Phosphoenolpyruvate bindingUniRule annotation2
Regioni122 – 126UDP-N-acetylglucosamine bindingUniRule annotation5

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CDF. Bacteria.
COG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiCDPHRAT.
OrthoDBiPOG091H01PG.

Family and domain databases

CDDicd01555. UdpNAET. 1 hit.
Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA. 1 hit.
InterProiView protein in InterPro
IPR001986. Enolpyruvate_Tfrase_dom.
IPR036968. Enolpyruvate_Tfrase_sf.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
PfamiView protein in Pfam
PF00275. EPSP_synthase. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIVRGGN RLSGTVKVEG AKNAVLPVIA ATLLASNGKS VIHDVPALSD
60 70 80 90 100
VYTISEVLRY LGADVKIEEN TITVDASQEL KFEAPFEYVR KMRASVLVMG
110 120 130 140 150
SLLARNGRAR VALPGGCAIG SRPIDQHLKG FEAMGAHVKV GNGFIDAEVK
160 170 180 190 200
GRLRGAKIYL DFPSVGATEN IMMAAVLAEG TTIIENCAKE PEIVDLANFL
210 220 230 240 250
NAMGAKVRGA GTGTIRIEGV DQLTGTTHTV IPDRIEAGTF MVAAAITGGN
260 270 280 290 300
VLVQGAVPEH LSSLIAKMEE MGVTIIEEGN GLRVIGPEKL KAVDIKTMPY
310 320 330 340 350
PGFPTDMQSQ MMALLLKAEG TSMVTETVFE NRFMHVEEFR RMNADIKIEG
360 370 380 390 400
RSVIINGPCN LQGAEVAATD LRAAAALILA GLAAEGYTRV TELRHLDRGY
410 420 430
VRFHEKLAAL GADIERVNDE SETAAEDVKV KDLNI
Length:435
Mass (Da):46,549
Last modified:July 28, 2009 - v1
Checksum:iD9CBCB6895B29552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS25928.1.
RefSeqiWP_015865295.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25928; ACS25928; GWCH70_3288.
KEGGigwc:GWCH70_3288.

Similar proteinsi

Entry informationi

Entry nameiC5D975_GEOSW
AccessioniPrimary (citable) accession number: C5D975
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 25, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported