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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Gene

murA

Organism
Geobacillus sp. (strain WCH70)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotationSAAS annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotationSAAS annotation

Pathway:ipeptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Pathway:ipeptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

PyruvateUniRule annotation

Enzyme and pathway databases

BioCyciGSP471223:GH2C-3402-MONOMER.
UniPathwayiUPA00219.
UPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotationSAAS annotation (EC:2.5.1.7UniRule annotationSAAS annotation)
Alternative name(s):
Enoylpyruvate transferaseUniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferaseUniRule annotation
Gene namesi
Name:murAUniRule annotation
Ordered Locus Names:GWCH70_3288Imported
OrganismiGeobacillus sp. (strain WCH70)Imported
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 11712-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_3288.

Structurei

3D structure databases

ProteinModelPortaliC5D975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
OrthoDBiEOG68M4GK.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIVRGGN RLSGTVKVEG AKNAVLPVIA ATLLASNGKS VIHDVPALSD
60 70 80 90 100
VYTISEVLRY LGADVKIEEN TITVDASQEL KFEAPFEYVR KMRASVLVMG
110 120 130 140 150
SLLARNGRAR VALPGGCAIG SRPIDQHLKG FEAMGAHVKV GNGFIDAEVK
160 170 180 190 200
GRLRGAKIYL DFPSVGATEN IMMAAVLAEG TTIIENCAKE PEIVDLANFL
210 220 230 240 250
NAMGAKVRGA GTGTIRIEGV DQLTGTTHTV IPDRIEAGTF MVAAAITGGN
260 270 280 290 300
VLVQGAVPEH LSSLIAKMEE MGVTIIEEGN GLRVIGPEKL KAVDIKTMPY
310 320 330 340 350
PGFPTDMQSQ MMALLLKAEG TSMVTETVFE NRFMHVEEFR RMNADIKIEG
360 370 380 390 400
RSVIINGPCN LQGAEVAATD LRAAAALILA GLAAEGYTRV TELRHLDRGY
410 420 430
VRFHEKLAAL GADIERVNDE SETAAEDVKV KDLNI
Length:435
Mass (Da):46,549
Last modified:July 28, 2009 - v1
Checksum:iD9CBCB6895B29552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS25928.1.
RefSeqiWP_015865295.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25928; ACS25928; GWCH70_3288.
KEGGigwc:GWCH70_3288.
PATRICi21975699. VBIGeoSp101709_3430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS25928.1.
RefSeqiWP_015865295.1. NC_012793.1.

3D structure databases

ProteinModelPortaliC5D975.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471223.GWCH70_3288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS25928; ACS25928; GWCH70_3288.
KEGGigwc:GWCH70_3288.
PATRICi21975699. VBIGeoSp101709_3430.

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
OrthoDBiEOG68M4GK.

Enzyme and pathway databases

UniPathwayiUPA00219.
UPA00219.
BioCyciGSP471223:GH2C-3402-MONOMER.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70Imported.

Entry informationi

Entry nameiC5D975_GEOSW
AccessioniPrimary (citable) accession number: C5D975
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.