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C5D8Q4 (C5D8Q4_GEOSW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:GWCH70_1051
OrganismGeobacillus sp. (strain WCH70) [Complete proteome] [HAMAP] EMBL ACS23911.1
Taxonomic identifier471223 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region120 – 12895-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1241Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
C5D8Q4 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: D63923DDA8AF6BC0

FASTA20722,610
        10         20         30         40         50         60 
MKKEIAAHLL EIGAVSLEPQ EPFTWSSGLK SPIYCDNRLT LAYPNVRNAI ADGLTKLIRA 

        70         80         90        100        110        120 
HFSNVEAIAG TATAGIPHAA WVSERLNLPM CYVRSQAKGH GKGKQIEGKV DKGQKVVVVE 

       130        140        150        160        170        180 
DLISTGGSSL NAVRALREAG CQVLGIVAIF TYGLEKAKQA FAENNVEVYT LTDYDTLIET 

       190        200 
AVELGVVTEQ DLTTLRKWRE NPEEWGK

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References

[1]"Complete sequence of chromosome of Geopacillus sp. WCH70."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Brumm P., Mead D.A., Richardson P.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WCH70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001638 Genomic DNA. Translation: ACS23911.1.
RefSeqYP_002949177.1. NC_012793.1.

3D structure databases

ProteinModelPortalC5D8Q4.
SMRC5D8Q4. Positions 1-206.
ModBaseSearch...

Protein-protein interaction databases

STRINGC5D8Q4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7976831.
GenomeReviewsGene locus GWCH70_1051 in contig CP001638_GR.
KEGGgwc:GWCH70_1051.
PATRIC21971028. VBIGeoSp101709_1129.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALPMTYVR.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC5D8Q4_GEOSW
AccessionPrimary (citable) accession number: C5D8Q4
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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