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Protein

UDP-N-acetylmuramyl-tripeptide synthetase

Gene

GWCH70_1016

Organism
Geobacillus sp. (strain WCH70)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP471223:GH2C-1100-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramyl-tripeptide synthetaseSAAS annotation (EC:6.3.2.-SAAS annotation)
Gene namesi
Ordered Locus Names:GWCH70_1016Imported
OrganismiGeobacillus sp. (strain WCH70)Imported
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000002386 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_1016.

Structurei

3D structure databases

ProteinModelPortaliC5D8L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9473Mur_ligaseInterPro annotationAdd
BLAST
Domaini106 – 311206Mur_ligase_MInterPro annotationAdd
BLAST
Domaini332 – 41786Mur_ligase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MurCDEF family. MurE subfamily.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107EEN. Bacteria.
COG0769. LUCA.
HOGENOMiHOG000268118.
KOiK01928.
OMAiHNHNIKF.
OrthoDBiEOG6PKFCR.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00208. MurE.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005761. UDP-N-AcMur-Glu-dNH2Pim_ligase.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01085. murE. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D8L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQTLLSYL HDFTTYVGEN PTITSIEMDS RQVKNGALFI CIKGFTVDGH
60 70 80 90 100
DFAKQAVENG AVAVIAERPL DVDVPVIVVR DSRRAMAMLA DAFYGQPTHR
110 120 130 140 150
LHLIGVTGTN GKTTTTHIIE HIARKANKKT GLIGTVHIKI GDHTYPTKNT
160 170 180 190 200
TPESLLLQRT FKQMVDEGVD VAVMEVSSHA LHMGRVHGCD YDVAVFTNLT
210 220 230 240 250
QDHLDYHGTM EEYRNAKGLL FAQLGNRYDH ERPKFAVLNN DDPASKYYKH
260 270 280 290 300
MTAASVITYG IETDSDIMAK KIDIVPSGMS FDLITPNGTV RVKTRLIGLF
310 320 330 340 350
NVYNLLAAVS ACLVSGIPLP VIVEAIEEIS GVAGRFETVD EGQNFTVIVD
360 370 380 390 400
YAHTPDSLEN VLKTIRQFAQ KKVYVVVGCG GDRDRTKRPL MAKTAVKYAD
410 420 430 440 450
VAIFTSDNPR SEDPEQILRD MEAGVPGERY VTIVDRKEAI YYAIEQAQEG
460 470 480 490
DIILIAGKGH ETYQIIGDRV IDFDDRLVAR EAIKERKNIC
Length:490
Mass (Da):54,388
Last modified:July 28, 2009 - v1
Checksum:i51130A205C60C782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS23876.1.
RefSeqiWP_015863352.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS23876; ACS23876; GWCH70_1016.
KEGGigwc:GWCH70_1016.
PATRICi21970958. VBIGeoSp101709_1094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS23876.1.
RefSeqiWP_015863352.1. NC_012793.1.

3D structure databases

ProteinModelPortaliC5D8L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471223.GWCH70_1016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS23876; ACS23876; GWCH70_1016.
KEGGigwc:GWCH70_1016.
PATRICi21970958. VBIGeoSp101709_1094.

Phylogenomic databases

eggNOGiENOG4107EEN. Bacteria.
COG0769. LUCA.
HOGENOMiHOG000268118.
KOiK01928.
OMAiHNHNIKF.
OrthoDBiEOG6PKFCR.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciGSP471223:GH2C-1100-MONOMER.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00208. MurE.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005761. UDP-N-AcMur-Glu-dNH2Pim_ligase.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01085. murE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70Imported.

Entry informationi

Entry nameiC5D8L9_GEOSW
AccessioniPrimary (citable) accession number: C5D8L9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.