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C5D827 (DAPEL_GEOSW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47
Gene names
Ordered Locus Names:GWCH70_0945
OrganismGeobacillus sp. (strain WCH70) [Complete proteome] [HAMAP]
Taxonomic identifier471223 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692

Catalytic activity

N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692

Sequence similarities

Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692
PRO_1000215932

Sites

Active site701 By similarity
Active site1291Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
C5D827 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: E403EAD6AC08B7C7

FASTA37641,928
        10         20         30         40         50         60 
MSSISPFVAI RRDLHKIPEL GFQEFKTQQY LLRYIHALPQ ERLEIQTWKT GIFVKVKGTA 

        70         80         90        100        110        120 
PRKMIGYRTD IDGLPIKEET GLPYSSEHEG NMHACGHDVH MSIALGLLTH FAEHPIQDDL 

       130        140        150        160        170        180 
LFIFQPAEEG PGGAKPMLES EIMKVWKPDM ILALHIAPEY PVGTIATKEG LLFANTSELF 

       190        200        210        220        230        240 
IDLKGKGGHA AFPHLANDMV VAACSLVTQL QSIVARNVDP LDSAVITIGK ISGGTVQNVI 

       250        260        270        280        290        300 
AEHARLEGTI RTLSVDSMKK VKERIEAMVS GIKMAYQCEA EIDYGSMYHQ VYNDPELTTE 

       310        320        330        340        350        360 
FIQFAENYQG IRFIRCKEAM TGEDFGYMLA EIPGFMFWLG VDSPYGLHHA KLTPNEAAID 

       370 
QGISFLISYI TWKGNN

« Hide

References

[1]"Complete sequence of chromosome of Geopacillus sp. WCH70."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Brumm P., Mead D.A., Richardson P.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WCH70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001638 Genomic DNA. Translation: ACS23808.1.
RefSeqYP_002949074.1. NC_012793.1.

3D structure databases

ProteinModelPortalC5D827.
ModBaseSearch...

Protein-protein interaction databases

STRING471223.GWCH70_0945.

Protein family/group databases

MEROPSM20.A27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS23808; ACS23808; GWCH70_0945.
GeneID7979162.
KEGGgwc:GWCH70_0945.
PATRIC21970808. VBIGeoSp101709_1019.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1473.
HOGENOMHOG000241404.
KOK05823.
OMAYMLAEIP.
ProtClustDBCLSK873387.

Enzyme and pathway databases

BioCycGSP471223:GH2C-1063-MONOMER.
UniPathwayUPA00034; UER00024.

Family and domain databases

HAMAPMF_01692. DapEL.
InterProIPR023905. AcetylDAP_deacetylase.
IPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMSSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMsTIGR01891. amidohydrolases. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. False negative.
PS00759. ARGE_DAPE_CPG2_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPEL_GEOSW
AccessionPrimary (citable) accession number: C5D827
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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