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C5D802

- ODO1_GEOSW

UniProt

C5D802 - ODO1_GEOSW

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciGSP471223:GH2C-1003-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:GWCH70_0919
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9529522-oxoglutarate dehydrogenase E1 componentPRO_1000213736Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi471223.GWCH70_0919.

Structurei

3D structure databases

ProteinModelPortaliC5D802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D802-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKQTMNYAE PWSQFYGPNL GYVMEMYEQY LEDPDSVDPE LKQLFKEWGA
60 70 80 90 100
PTTEAERFDH SESAAKTYQT FRLPENPTIF SKLVAAVKLA DKIRHYGHLA
110 120 130 140 150
ADINPLNTQN KDTRRIELSE FDLTEDDLKQ IPVAFICPHA PAHVKNGLDA
160 170 180 190 200
INHLRKIYTD KIAFEFSQVH NLEERNWLIS QIESGAYYPS LTNEEKVALL
210 220 230 240 250
RRLTEVEGFE KFLHRTFVGQ KRFSIEGLDS MVPLLDELIR HSIEEEVKAV
260 270 280 290 300
NIGMAHRGRL NVLAHVLGKP YEMIFAEFQH AESKDFMPSE GSVAITYGWT
310 320 330 340 350
GDVKYHLGAA RRLRNKNEHT MRITLANNPS HLEVVNPVVL GFTRAAQEDR
360 370 380 390 400
SNAGVPSQDT DSAFAIMIHG DAAFPGQGIV AETLNLSRLQ GYQTGGSIHI
410 420 430 440 450
IANNMIGFTT ESYDSRSTKY ASDIAKGFEI PIVHVNADDP EACLAAANLA
460 470 480 490 500
FAYRKRFKKD FVIDLIGYRR FGHNEMDEPM ATNPTMYSII QQHPTVRQLY
510 520 530 540 550
AQKLIEKGII TKEAVEEMER EVAERLKIAY EKVPKDESKL DFIMDPPKPV
560 570 580 590 600
ASKLPFVKTS VEKDVLRRLN KELLQFPSDF HVFNKLERIL KRREGVFDGK
610 620 630 640 650
GKIDWAHAEI LAFATILRDG VPIRLTGQDS QRGTFAQRHL VLHDMKTGEE
660 670 680 690 700
FVPLHHISDA NASFVVYNSP LTEAAVLGYE YGYNVFAPET LVLWEAQFGD
710 720 730 740 750
FANMAQVMFD QFISSGRAKW GQKSGLVMLL PHGYEGQGPE HSSGRLERFL
760 770 780 790 800
QLAAENNWTV ANLSTAAQYF HILRRQAGIL QREEVRPLVL MTPKSLLRHP
810 820 830 840 850
LAASDVEEFT NGQFHPVIEQ KGLGENREKV ERIILCTGKF AIDLAEQINK
860 870 880 890 900
MEGLDWLHIV RVEELYPFPK EELQAIFARY PNVKEIIWAQ EEPKNMGSWC
910 920 930 940 950
YVEPKLREIA PDEVDVSYIG RRRRASPAEG DPVVHRKEQE RIIQCALTKK

EQ
Length:952
Mass (Da):108,481
Last modified:July 28, 2009 - v1
Checksum:iD00671DCFA511D3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS23783.1.
RefSeqiWP_015863262.1. NC_012793.1.
YP_002949049.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS23783; ACS23783; GWCH70_0919.
GeneIDi7976647.
KEGGigwc:GWCH70_0919.
PATRICi21970752. VBIGeoSp101709_0991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS23783.1 .
RefSeqi WP_015863262.1. NC_012793.1.
YP_002949049.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D802.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_0919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS23783 ; ACS23783 ; GWCH70_0919 .
GeneIDi 7976647.
KEGGi gwc:GWCH70_0919.
PATRICi 21970752. VBIGeoSp101709_0991.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci GSP471223:GH2C-1003-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiODO1_GEOSW
AccessioniPrimary (citable) accession number: C5D802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3