SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C5D802

- ODO1_GEOSW

UniProt

C5D802 - ODO1_GEOSW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

2-oxoglutarate dehydrogenase E1 component

Gene
odhA, GWCH70_0919
Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciGSP471223:GH2C-1003-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:GWCH70_0919
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9529522-oxoglutarate dehydrogenase E1 componentUniRule annotationPRO_1000213736Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi471223.GWCH70_0919.

Structurei

3D structure databases

ProteinModelPortaliC5D802.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D802-1 [UniParc]FASTAAdd to Basket

« Hide

MTKQTMNYAE PWSQFYGPNL GYVMEMYEQY LEDPDSVDPE LKQLFKEWGA    50
PTTEAERFDH SESAAKTYQT FRLPENPTIF SKLVAAVKLA DKIRHYGHLA 100
ADINPLNTQN KDTRRIELSE FDLTEDDLKQ IPVAFICPHA PAHVKNGLDA 150
INHLRKIYTD KIAFEFSQVH NLEERNWLIS QIESGAYYPS LTNEEKVALL 200
RRLTEVEGFE KFLHRTFVGQ KRFSIEGLDS MVPLLDELIR HSIEEEVKAV 250
NIGMAHRGRL NVLAHVLGKP YEMIFAEFQH AESKDFMPSE GSVAITYGWT 300
GDVKYHLGAA RRLRNKNEHT MRITLANNPS HLEVVNPVVL GFTRAAQEDR 350
SNAGVPSQDT DSAFAIMIHG DAAFPGQGIV AETLNLSRLQ GYQTGGSIHI 400
IANNMIGFTT ESYDSRSTKY ASDIAKGFEI PIVHVNADDP EACLAAANLA 450
FAYRKRFKKD FVIDLIGYRR FGHNEMDEPM ATNPTMYSII QQHPTVRQLY 500
AQKLIEKGII TKEAVEEMER EVAERLKIAY EKVPKDESKL DFIMDPPKPV 550
ASKLPFVKTS VEKDVLRRLN KELLQFPSDF HVFNKLERIL KRREGVFDGK 600
GKIDWAHAEI LAFATILRDG VPIRLTGQDS QRGTFAQRHL VLHDMKTGEE 650
FVPLHHISDA NASFVVYNSP LTEAAVLGYE YGYNVFAPET LVLWEAQFGD 700
FANMAQVMFD QFISSGRAKW GQKSGLVMLL PHGYEGQGPE HSSGRLERFL 750
QLAAENNWTV ANLSTAAQYF HILRRQAGIL QREEVRPLVL MTPKSLLRHP 800
LAASDVEEFT NGQFHPVIEQ KGLGENREKV ERIILCTGKF AIDLAEQINK 850
MEGLDWLHIV RVEELYPFPK EELQAIFARY PNVKEIIWAQ EEPKNMGSWC 900
YVEPKLREIA PDEVDVSYIG RRRRASPAEG DPVVHRKEQE RIIQCALTKK 950
EQ 952
Length:952
Mass (Da):108,481
Last modified:July 28, 2009 - v1
Checksum:iD00671DCFA511D3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS23783.1.
RefSeqiWP_015863262.1. NC_012793.1.
YP_002949049.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS23783; ACS23783; GWCH70_0919.
GeneIDi7976647.
KEGGigwc:GWCH70_0919.
PATRICi21970752. VBIGeoSp101709_0991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS23783.1 .
RefSeqi WP_015863262.1. NC_012793.1.
YP_002949049.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D802.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_0919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS23783 ; ACS23783 ; GWCH70_0919 .
GeneIDi 7976647.
KEGGi gwc:GWCH70_0919.
PATRICi 21970752. VBIGeoSp101709_0991.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci GSP471223:GH2C-1003-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiODO1_GEOSW
AccessioniPrimary (citable) accession number: C5D802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi