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C5D802 (ODO1_GEOSW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:odhA
Ordered Locus Names:GWCH70_0919
OrganismGeobacillus sp. (strain WCH70) [Complete proteome] [HAMAP]
Taxonomic identifier471223 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length952 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionoxoglutarate dehydrogenase (succinyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9529522-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_1000213736

Sequences

Sequence LengthMass (Da)Tools
C5D802 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: D00671DCFA511D3B

FASTA952108,481
        10         20         30         40         50         60 
MTKQTMNYAE PWSQFYGPNL GYVMEMYEQY LEDPDSVDPE LKQLFKEWGA PTTEAERFDH 

        70         80         90        100        110        120 
SESAAKTYQT FRLPENPTIF SKLVAAVKLA DKIRHYGHLA ADINPLNTQN KDTRRIELSE 

       130        140        150        160        170        180 
FDLTEDDLKQ IPVAFICPHA PAHVKNGLDA INHLRKIYTD KIAFEFSQVH NLEERNWLIS 

       190        200        210        220        230        240 
QIESGAYYPS LTNEEKVALL RRLTEVEGFE KFLHRTFVGQ KRFSIEGLDS MVPLLDELIR 

       250        260        270        280        290        300 
HSIEEEVKAV NIGMAHRGRL NVLAHVLGKP YEMIFAEFQH AESKDFMPSE GSVAITYGWT 

       310        320        330        340        350        360 
GDVKYHLGAA RRLRNKNEHT MRITLANNPS HLEVVNPVVL GFTRAAQEDR SNAGVPSQDT 

       370        380        390        400        410        420 
DSAFAIMIHG DAAFPGQGIV AETLNLSRLQ GYQTGGSIHI IANNMIGFTT ESYDSRSTKY 

       430        440        450        460        470        480 
ASDIAKGFEI PIVHVNADDP EACLAAANLA FAYRKRFKKD FVIDLIGYRR FGHNEMDEPM 

       490        500        510        520        530        540 
ATNPTMYSII QQHPTVRQLY AQKLIEKGII TKEAVEEMER EVAERLKIAY EKVPKDESKL 

       550        560        570        580        590        600 
DFIMDPPKPV ASKLPFVKTS VEKDVLRRLN KELLQFPSDF HVFNKLERIL KRREGVFDGK 

       610        620        630        640        650        660 
GKIDWAHAEI LAFATILRDG VPIRLTGQDS QRGTFAQRHL VLHDMKTGEE FVPLHHISDA 

       670        680        690        700        710        720 
NASFVVYNSP LTEAAVLGYE YGYNVFAPET LVLWEAQFGD FANMAQVMFD QFISSGRAKW 

       730        740        750        760        770        780 
GQKSGLVMLL PHGYEGQGPE HSSGRLERFL QLAAENNWTV ANLSTAAQYF HILRRQAGIL 

       790        800        810        820        830        840 
QREEVRPLVL MTPKSLLRHP LAASDVEEFT NGQFHPVIEQ KGLGENREKV ERIILCTGKF 

       850        860        870        880        890        900 
AIDLAEQINK MEGLDWLHIV RVEELYPFPK EELQAIFARY PNVKEIIWAQ EEPKNMGSWC 

       910        920        930        940        950 
YVEPKLREIA PDEVDVSYIG RRRRASPAEG DPVVHRKEQE RIIQCALTKK EQ 

« Hide

References

[1]"Complete sequence of chromosome of Geopacillus sp. WCH70."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Brumm P., Mead D.A., Richardson P.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WCH70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001638 Genomic DNA. Translation: ACS23783.1.
RefSeqYP_002949049.1. NC_012793.1.

3D structure databases

ProteinModelPortalC5D802.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471223.GWCH70_0919.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS23783; ACS23783; GWCH70_0919.
GeneID7976647.
KEGGgwc:GWCH70_0919.
PATRIC21970752. VBIGeoSp101709_0991.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMARSEAGYP.
OrthoDBEOG6V1M1F.
ProtClustDBPRK09404.

Enzyme and pathway databases

BioCycGSP471223:GH2C-1003-MONOMER.

Family and domain databases

HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_GEOSW
AccessionPrimary (citable) accession number: C5D802
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families