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C5D6D7

- SYL_GEOSW

UniProt

C5D6D7 - SYL_GEOSW

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Protein

Leucine--tRNA ligase

Gene
leuS, GWCH70_2764
Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP471223:GH2C-2860-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:GWCH70_2764
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotationPRO_1000202221Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_2764.

Structurei

3D structure databases

ProteinModelPortaliC5D6D7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5D6D7-1 [UniParc]FASTAAdd to Basket

« Hide

MSFNHREIEK KWQEYWEKNK TFKTVDDDDK PKFYVLDMFP YPSGAGLHVG    50
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT 100
EKNINTFRRQ IKSLGFSYDW DREINTTDPN YYKWTQWIFL KLYEKGLAYM 150
DEVPVNWCPA LGTVLANEEV IDGKSERGGH PVIRKPMKQW LLRITAYADR 200
LLEDLEELDW PESVKEMQRN WIGRSEGAEI RFEVDGHDET FTVFTTRPDT 250
LFGATYTVLA PEHPLVEKIT TPEQKAAVEA YLDAIKSKSD LERTDLAKEK 300
TGVFTGAYAI HPVTGEKLPI WIADYVLMSY GTGAIMAVPA HDERDYEFAK 350
KFNLPIKEVV AGGDIAKEAY TGDGEHINSD FLNGLNKEEA IKKMIEWLEA 400
NGKGQKKVTY RLRDWLFSRQ RYWGEPIPII HWEDGTMTPV PEEELPLKLP 450
KTDKIKPTGT GESPLANIEE WVNVVDPKTG KKGRRETNTM PQWAGSCWYY 500
LRYIDPHNDK QLADPEKLKK WLPVDVYIGG AEHAVLHLLY ARFWHKFLYD 550
IGVVPTKEPF QKLFNQGMIL GENNEKMSKS RGNVVNPDDI IESHGADTLR 600
LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVDENGN LNPKIVDNPE 650
TDTLERVYHQ TVKKVTEDYE ALRFNTAISQ LMVFINEAYK APVLPKEYME 700
GFVKLLSPVC PHIGEELWEK LGHNNTIAYE PWPTYDESKL VEEEVEIVVQ 750
VNGKVRAKLR VPADISKEKL EQLAMEDEKI KEHIAGKTVR KVITVPGKLV 800
NIVAN 805
Length:805
Mass (Da):92,561
Last modified:July 28, 2009 - v1
Checksum:iEC08CF540D2FB8D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25453.1.
RefSeqiWP_015864859.1. NC_012793.1.
YP_002950719.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25453; ACS25453; GWCH70_2764.
GeneIDi7977987.
KEGGigwc:GWCH70_2764.
PATRICi21974594. VBIGeoSp101709_2898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25453.1 .
RefSeqi WP_015864859.1. NC_012793.1.
YP_002950719.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D6D7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_2764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS25453 ; ACS25453 ; GWCH70_2764 .
GeneIDi 7977987.
KEGGi gwc:GWCH70_2764.
PATRICi 21974594. VBIGeoSp101709_2898.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GSP471223:GH2C-2860-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiSYL_GEOSW
AccessioniPrimary (citable) accession number: C5D6D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi