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C5D6D7

- SYL_GEOSW

UniProt

C5D6D7 - SYL_GEOSW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGSP471223:GH2C-2860-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:GWCH70_2764
    OrganismiGeobacillus sp. (strain WCH70)
    Taxonomic identifieri471223 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000002386: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Leucine--tRNA ligasePRO_1000202221Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi471223.GWCH70_2764.

    Structurei

    3D structure databases

    ProteinModelPortaliC5D6D7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5D6D7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFNHREIEK KWQEYWEKNK TFKTVDDDDK PKFYVLDMFP YPSGAGLHVG    50
    HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT 100
    EKNINTFRRQ IKSLGFSYDW DREINTTDPN YYKWTQWIFL KLYEKGLAYM 150
    DEVPVNWCPA LGTVLANEEV IDGKSERGGH PVIRKPMKQW LLRITAYADR 200
    LLEDLEELDW PESVKEMQRN WIGRSEGAEI RFEVDGHDET FTVFTTRPDT 250
    LFGATYTVLA PEHPLVEKIT TPEQKAAVEA YLDAIKSKSD LERTDLAKEK 300
    TGVFTGAYAI HPVTGEKLPI WIADYVLMSY GTGAIMAVPA HDERDYEFAK 350
    KFNLPIKEVV AGGDIAKEAY TGDGEHINSD FLNGLNKEEA IKKMIEWLEA 400
    NGKGQKKVTY RLRDWLFSRQ RYWGEPIPII HWEDGTMTPV PEEELPLKLP 450
    KTDKIKPTGT GESPLANIEE WVNVVDPKTG KKGRRETNTM PQWAGSCWYY 500
    LRYIDPHNDK QLADPEKLKK WLPVDVYIGG AEHAVLHLLY ARFWHKFLYD 550
    IGVVPTKEPF QKLFNQGMIL GENNEKMSKS RGNVVNPDDI IESHGADTLR 600
    LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVDENGN LNPKIVDNPE 650
    TDTLERVYHQ TVKKVTEDYE ALRFNTAISQ LMVFINEAYK APVLPKEYME 700
    GFVKLLSPVC PHIGEELWEK LGHNNTIAYE PWPTYDESKL VEEEVEIVVQ 750
    VNGKVRAKLR VPADISKEKL EQLAMEDEKI KEHIAGKTVR KVITVPGKLV 800
    NIVAN 805
    Length:805
    Mass (Da):92,561
    Last modified:July 28, 2009 - v1
    Checksum:iEC08CF540D2FB8D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001638 Genomic DNA. Translation: ACS25453.1.
    RefSeqiWP_015864859.1. NC_012793.1.
    YP_002950719.1. NC_012793.1.

    Genome annotation databases

    EnsemblBacteriaiACS25453; ACS25453; GWCH70_2764.
    GeneIDi7977987.
    KEGGigwc:GWCH70_2764.
    PATRICi21974594. VBIGeoSp101709_2898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001638 Genomic DNA. Translation: ACS25453.1 .
    RefSeqi WP_015864859.1. NC_012793.1.
    YP_002950719.1. NC_012793.1.

    3D structure databases

    ProteinModelPortali C5D6D7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471223.GWCH70_2764.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS25453 ; ACS25453 ; GWCH70_2764 .
    GeneIDi 7977987.
    KEGGi gwc:GWCH70_2764.
    PATRICi 21974594. VBIGeoSp101709_2898.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GSP471223:GH2C-2860-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WCH70.

    Entry informationi

    Entry nameiSYL_GEOSW
    AccessioniPrimary (citable) accession number: C5D6D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3