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C5D654

- MDH_GEOSW

UniProt

C5D654 - MDH_GEOSW

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Protein

Malate dehydrogenase

Gene
mdh, GWCH70_2677
Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NAD By similarity
Binding sitei87 – 871Substrate By similarity
Binding sitei93 – 931Substrate By similarity
Binding sitei100 – 1001NAD By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei156 – 1561Substrate By similarity
Active sitei180 – 1801Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NAD By similarity
Nucleotide bindingi123 – 1253NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciGSP471223:GH2C-2773-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:GWCH70_2677
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Malate dehydrogenaseUniRule annotationPRO_1000206444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_2677.

Structurei

3D structure databases

ProteinModelPortaliC5D654.
SMRiC5D654. Positions 5-309.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D654-1 [UniParc]FASTAAdd to Basket

« Hide

MTMKRKKISV IGAGFTGATT AFILAQKELG DVVLVDIPQL ENPTKGKALD    50
MLESSPVLGF DANIIGTSDY ADTADSDIVV ITAGIARKPG MSRDDLVTTN 100
QKIMKQVTKE VVKYSPNCYI IVLTNPVDAM TYTVFKESGF PKNRVIGQSG 150
VLDTARFRTF VAQELNISVK DVTGFVLGGH GDDMVPLVRY SYAGGIPLEK 200
LIPKDRLDAI VERTRKGGGE IVNLLGNGSA YYAPAASLAE MVEAIIKDQR 250
RILPAIAYLE GEYGYEGIYL GVPTILGGNG IEKVIELELT EEEKAALAKS 300
VESVKNVMRV LE 312
Length:312
Mass (Da):33,710
Last modified:July 28, 2009 - v1
Checksum:i50B81B6F46D7EEC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25370.1.
RefSeqiWP_015864778.1. NC_012793.1.
YP_002950636.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25370; ACS25370; GWCH70_2677.
GeneIDi7976499.
KEGGigwc:GWCH70_2677.
PATRICi21974414. VBIGeoSp101709_2808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25370.1 .
RefSeqi WP_015864778.1. NC_012793.1.
YP_002950636.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D654.
SMRi C5D654. Positions 5-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_2677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS25370 ; ACS25370 ; GWCH70_2677 .
GeneIDi 7976499.
KEGGi gwc:GWCH70_2677.
PATRICi 21974414. VBIGeoSp101709_2808.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci GSP471223:GH2C-2773-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiMDH_GEOSW
AccessioniPrimary (citable) accession number: C5D654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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