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C5D5Q8

- MUTS2_GEOSW

UniProt

C5D5Q8 - MUTS2_GEOSW

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Protein

Endonuclease MutS2

Gene
mutS2, GWCH70_2632
Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi335 – 3428ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. endonuclease activity Source: UniProtKB-HAMAP
  4. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: InterPro
  2. negative regulation of DNA recombination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP471223:GH2C-2728-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease MutS2 (EC:3.1.-.-)
Gene namesi
Name:mutS2
Ordered Locus Names:GWCH70_2632
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 784784Endonuclease MutS2UniRule annotationPRO_1000202682Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi471223.GWCH70_2632.

Structurei

3D structure databases

ProteinModelPortaliC5D5Q8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini709 – 78476SmrAdd
BLAST

Sequence similaritiesi

Contains 1 Smr domain.

Phylogenomic databases

eggNOGiCOG1193.
HOGENOMiHOG000135096.
KOiK07456.
OMAiFGGIVHD.
OrthoDBiEOG6P5ZC4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00092. MutS2.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamiPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFiPIRSF005814. MutS_YshD. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01069. mutS2. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5D5Q8-1 [UniParc]FASTAAdd to Basket

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MHTRVLHVLE FDKVKEQLLE HVSSSLGKEK VEKLFPSSHF AEVTNWQEET    50
DEAVAALRLR GHVPLGGIFD IRASLKRAKI GGTLSPHELL DIASTISASR 100
QLKQFIESLH EEKEEFPHLA GYAEKLAALP EVQQAIERCI DDHGEVMDHA 150
SERLRSIRQQ LRTTEARVRE KLENIIRSQS AQKMLSDAII TIRNDRYVIP 200
VKQEYRGVYG GIVHDQSASG ATLFIEPQAV VELNNQLQEA RVKEKREIER 250
ILTELTSIVA EHAEALLENV DILAQLDFIF AKAKYANKLK ATKPVMNDRG 300
YIRLLQARHP LIDQDVVVPN DIELGKDYTT IVITGPNTGG KTVTLKTIGL 350
LTLMAQAGLF IPALDGSELA VFRSVYADIG DEQSIEQSLS TFSSHMVNIV 400
DILRNVDHES LVLFDELGAG TDPQEGAALA IAILDEVHGR GARTVATTHY 450
PELKAYGYNR DGVINASVEF DTETLRPTYK LLIGIPGRSN AFEISKRLGL 500
DERIIERAKS HISAESNKVE NMIASLEQSK KRAEEEEKKA KEARMEAEKL 550
RSDWEQKWEE LHEKRDEIIE EAKRKAADIV RASQQEAERI IRELRRMQKE 600
KQAEIKEHEL IEAKKRLEEA IPTLEKKKKE RKKQTQHAFQ PGDEVKVTSL 650
NQKGYLVEKV SDDEWQVQLG ILKMKINERD LEYIGSAPKT ETKPLATVKG 700
KDYHVGLELD LRGERYEDAI VRLEKYIDDA LLAGYPRVSI IHGKGTGALR 750
KGVQEFLKKH RSVKNFHFGE ANEGGTGVTI VELK 784
Length:784
Mass (Da):88,538
Last modified:July 28, 2009 - v1
Checksum:i1591E98610B9C536
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25326.1.
RefSeqiWP_015864737.1. NC_012793.1.
YP_002950592.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25326; ACS25326; GWCH70_2632.
GeneIDi7978295.
KEGGigwc:GWCH70_2632.
PATRICi21974330. VBIGeoSp101709_2766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25326.1 .
RefSeqi WP_015864737.1. NC_012793.1.
YP_002950592.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D5Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_2632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS25326 ; ACS25326 ; GWCH70_2632 .
GeneIDi 7978295.
KEGGi gwc:GWCH70_2632.
PATRICi 21974330. VBIGeoSp101709_2766.

Phylogenomic databases

eggNOGi COG1193.
HOGENOMi HOG000135096.
KOi K07456.
OMAi FGGIVHD.
OrthoDBi EOG6P5ZC4.

Enzyme and pathway databases

BioCyci GSP471223:GH2C-2728-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00092. MutS2.
InterProi IPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view ]
PANTHERi PTHR11361:SF14. PTHR11361:SF14. 1 hit.
Pfami PF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view ]
PIRSFi PIRSF005814. MutS_YshD. 1 hit.
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01069. mutS2. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiMUTS2_GEOSW
AccessioniPrimary (citable) accession number: C5D5Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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