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C5D5Q8

- MUTS2_GEOSW

UniProt

C5D5Q8 - MUTS2_GEOSW

Protein

Endonuclease MutS2

Gene

mutS2

Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi335 – 3428ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. endonuclease activity Source: UniProtKB-HAMAP
    4. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: InterPro
    2. negative regulation of DNA recombination Source: InterPro

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGSP471223:GH2C-2728-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
    Gene namesi
    Name:mutS2UniRule annotation
    Ordered Locus Names:GWCH70_2632
    OrganismiGeobacillus sp. (strain WCH70)
    Taxonomic identifieri471223 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000002386: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 784784Endonuclease MutS2PRO_1000202682Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi471223.GWCH70_2632.

    Structurei

    3D structure databases

    ProteinModelPortaliC5D5Q8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini709 – 78476SmrUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation
    Contains 1 Smr domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1193.
    HOGENOMiHOG000135096.
    KOiK07456.
    OMAiFGGIVHD.
    OrthoDBiEOG6P5ZC4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00092. MutS2.
    InterProiIPR000432. DNA_mismatch_repair_MutS_C.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR005747. MutS2.
    IPR027417. P-loop_NTPase.
    IPR002625. Smr/MutS2_C.
    [Graphical view]
    PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
    PfamiPF05192. MutS_III. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF01713. Smr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005814. MutS_YshD. 1 hit.
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    SM00463. SMR. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01069. mutS2. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50828. SMR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5D5Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHTRVLHVLE FDKVKEQLLE HVSSSLGKEK VEKLFPSSHF AEVTNWQEET    50
    DEAVAALRLR GHVPLGGIFD IRASLKRAKI GGTLSPHELL DIASTISASR 100
    QLKQFIESLH EEKEEFPHLA GYAEKLAALP EVQQAIERCI DDHGEVMDHA 150
    SERLRSIRQQ LRTTEARVRE KLENIIRSQS AQKMLSDAII TIRNDRYVIP 200
    VKQEYRGVYG GIVHDQSASG ATLFIEPQAV VELNNQLQEA RVKEKREIER 250
    ILTELTSIVA EHAEALLENV DILAQLDFIF AKAKYANKLK ATKPVMNDRG 300
    YIRLLQARHP LIDQDVVVPN DIELGKDYTT IVITGPNTGG KTVTLKTIGL 350
    LTLMAQAGLF IPALDGSELA VFRSVYADIG DEQSIEQSLS TFSSHMVNIV 400
    DILRNVDHES LVLFDELGAG TDPQEGAALA IAILDEVHGR GARTVATTHY 450
    PELKAYGYNR DGVINASVEF DTETLRPTYK LLIGIPGRSN AFEISKRLGL 500
    DERIIERAKS HISAESNKVE NMIASLEQSK KRAEEEEKKA KEARMEAEKL 550
    RSDWEQKWEE LHEKRDEIIE EAKRKAADIV RASQQEAERI IRELRRMQKE 600
    KQAEIKEHEL IEAKKRLEEA IPTLEKKKKE RKKQTQHAFQ PGDEVKVTSL 650
    NQKGYLVEKV SDDEWQVQLG ILKMKINERD LEYIGSAPKT ETKPLATVKG 700
    KDYHVGLELD LRGERYEDAI VRLEKYIDDA LLAGYPRVSI IHGKGTGALR 750
    KGVQEFLKKH RSVKNFHFGE ANEGGTGVTI VELK 784
    Length:784
    Mass (Da):88,538
    Last modified:July 28, 2009 - v1
    Checksum:i1591E98610B9C536
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001638 Genomic DNA. Translation: ACS25326.1.
    RefSeqiWP_015864737.1. NC_012793.1.
    YP_002950592.1. NC_012793.1.

    Genome annotation databases

    EnsemblBacteriaiACS25326; ACS25326; GWCH70_2632.
    GeneIDi7978295.
    KEGGigwc:GWCH70_2632.
    PATRICi21974330. VBIGeoSp101709_2766.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001638 Genomic DNA. Translation: ACS25326.1 .
    RefSeqi WP_015864737.1. NC_012793.1.
    YP_002950592.1. NC_012793.1.

    3D structure databases

    ProteinModelPortali C5D5Q8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471223.GWCH70_2632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS25326 ; ACS25326 ; GWCH70_2632 .
    GeneIDi 7978295.
    KEGGi gwc:GWCH70_2632.
    PATRICi 21974330. VBIGeoSp101709_2766.

    Phylogenomic databases

    eggNOGi COG1193.
    HOGENOMi HOG000135096.
    KOi K07456.
    OMAi FGGIVHD.
    OrthoDBi EOG6P5ZC4.

    Enzyme and pathway databases

    BioCyci GSP471223:GH2C-2728-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00092. MutS2.
    InterProi IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR005747. MutS2.
    IPR027417. P-loop_NTPase.
    IPR002625. Smr/MutS2_C.
    [Graphical view ]
    PANTHERi PTHR11361:SF14. PTHR11361:SF14. 1 hit.
    Pfami PF05192. MutS_III. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF01713. Smr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005814. MutS_YshD. 1 hit.
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    SM00463. SMR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01069. mutS2. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50828. SMR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WCH70.

    Entry informationi

    Entry nameiMUTS2_GEOSW
    AccessioniPrimary (citable) accession number: C5D5Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3