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C5D5Q8

- MUTS2_GEOSW

UniProt

C5D5Q8 - MUTS2_GEOSW

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Protein

Endonuclease MutS2

Gene

mutS2

Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi335 – 3428ATPUniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. endonuclease activity Source: UniProtKB-HAMAP
  4. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: InterPro
  2. negative regulation of DNA recombination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP471223:GH2C-2728-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
Gene namesi
Name:mutS2UniRule annotation
Ordered Locus Names:GWCH70_2632
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 784784Endonuclease MutS2PRO_1000202682Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi471223.GWCH70_2632.

Structurei

3D structure databases

ProteinModelPortaliC5D5Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini709 – 78476SmrUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation
Contains 1 Smr domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1193.
HOGENOMiHOG000135096.
KOiK07456.
OMAiFGGIVHD.
OrthoDBiEOG6P5ZC4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00092. MutS2.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamiPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFiPIRSF005814. MutS_YshD. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01069. mutS2. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5D5Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHTRVLHVLE FDKVKEQLLE HVSSSLGKEK VEKLFPSSHF AEVTNWQEET
60 70 80 90 100
DEAVAALRLR GHVPLGGIFD IRASLKRAKI GGTLSPHELL DIASTISASR
110 120 130 140 150
QLKQFIESLH EEKEEFPHLA GYAEKLAALP EVQQAIERCI DDHGEVMDHA
160 170 180 190 200
SERLRSIRQQ LRTTEARVRE KLENIIRSQS AQKMLSDAII TIRNDRYVIP
210 220 230 240 250
VKQEYRGVYG GIVHDQSASG ATLFIEPQAV VELNNQLQEA RVKEKREIER
260 270 280 290 300
ILTELTSIVA EHAEALLENV DILAQLDFIF AKAKYANKLK ATKPVMNDRG
310 320 330 340 350
YIRLLQARHP LIDQDVVVPN DIELGKDYTT IVITGPNTGG KTVTLKTIGL
360 370 380 390 400
LTLMAQAGLF IPALDGSELA VFRSVYADIG DEQSIEQSLS TFSSHMVNIV
410 420 430 440 450
DILRNVDHES LVLFDELGAG TDPQEGAALA IAILDEVHGR GARTVATTHY
460 470 480 490 500
PELKAYGYNR DGVINASVEF DTETLRPTYK LLIGIPGRSN AFEISKRLGL
510 520 530 540 550
DERIIERAKS HISAESNKVE NMIASLEQSK KRAEEEEKKA KEARMEAEKL
560 570 580 590 600
RSDWEQKWEE LHEKRDEIIE EAKRKAADIV RASQQEAERI IRELRRMQKE
610 620 630 640 650
KQAEIKEHEL IEAKKRLEEA IPTLEKKKKE RKKQTQHAFQ PGDEVKVTSL
660 670 680 690 700
NQKGYLVEKV SDDEWQVQLG ILKMKINERD LEYIGSAPKT ETKPLATVKG
710 720 730 740 750
KDYHVGLELD LRGERYEDAI VRLEKYIDDA LLAGYPRVSI IHGKGTGALR
760 770 780
KGVQEFLKKH RSVKNFHFGE ANEGGTGVTI VELK
Length:784
Mass (Da):88,538
Last modified:July 28, 2009 - v1
Checksum:i1591E98610B9C536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS25326.1.
RefSeqiWP_015864737.1. NC_012793.1.
YP_002950592.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25326; ACS25326; GWCH70_2632.
GeneIDi7978295.
KEGGigwc:GWCH70_2632.
PATRICi21974330. VBIGeoSp101709_2766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS25326.1 .
RefSeqi WP_015864737.1. NC_012793.1.
YP_002950592.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D5Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_2632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS25326 ; ACS25326 ; GWCH70_2632 .
GeneIDi 7978295.
KEGGi gwc:GWCH70_2632.
PATRICi 21974330. VBIGeoSp101709_2766.

Phylogenomic databases

eggNOGi COG1193.
HOGENOMi HOG000135096.
KOi K07456.
OMAi FGGIVHD.
OrthoDBi EOG6P5ZC4.

Enzyme and pathway databases

BioCyci GSP471223:GH2C-2728-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00092. MutS2.
InterProi IPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view ]
PANTHERi PTHR11361:SF14. PTHR11361:SF14. 1 hit.
Pfami PF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view ]
PIRSFi PIRSF005814. MutS_YshD. 1 hit.
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01069. mutS2. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiMUTS2_GEOSW
AccessioniPrimary (citable) accession number: C5D5Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3