C5D5Q8 (MUTS2_GEOSW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MutS2 protein

Gene names

Name:	mutS2
Ordered Locus Names:	GWCH70_2632

Organism

Geobacillus sp. (strain WCH70) [Complete proteome] [HAMAP]

Taxonomic identifier

471223 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	784 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the DNA mismatch repair MutS family. Contains 1 Smr domain.

Ontologies

Keywords
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	maintenance of fidelity involved in DNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP damaged DNA binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 784	784	MutS2 protein HAMAP-Rule MF_00092		PRO_1000202682
Regions
	Domain	709 – 784	76	Smr
	Nucleotide binding	335 – 342	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	C5D5Q8 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 1591E98610B9C536	FASTA	784	88,538
	10 20 30 40 50 60 MHTRVLHVLE FDKVKEQLLE HVSSSLGKEK VEKLFPSSHF AEVTNWQEET DEAVAALRLR 70 80 90 100 110 120 GHVPLGGIFD IRASLKRAKI GGTLSPHELL DIASTISASR QLKQFIESLH EEKEEFPHLA 130 140 150 160 170 180 GYAEKLAALP EVQQAIERCI DDHGEVMDHA SERLRSIRQQ LRTTEARVRE KLENIIRSQS 190 200 210 220 230 240 AQKMLSDAII TIRNDRYVIP VKQEYRGVYG GIVHDQSASG ATLFIEPQAV VELNNQLQEA 250 260 270 280 290 300 RVKEKREIER ILTELTSIVA EHAEALLENV DILAQLDFIF AKAKYANKLK ATKPVMNDRG 310 320 330 340 350 360 YIRLLQARHP LIDQDVVVPN DIELGKDYTT IVITGPNTGG KTVTLKTIGL LTLMAQAGLF 370 380 390 400 410 420 IPALDGSELA VFRSVYADIG DEQSIEQSLS TFSSHMVNIV DILRNVDHES LVLFDELGAG 430 440 450 460 470 480 TDPQEGAALA IAILDEVHGR GARTVATTHY PELKAYGYNR DGVINASVEF DTETLRPTYK 490 500 510 520 530 540 LLIGIPGRSN AFEISKRLGL DERIIERAKS HISAESNKVE NMIASLEQSK KRAEEEEKKA 550 560 570 580 590 600 KEARMEAEKL RSDWEQKWEE LHEKRDEIIE EAKRKAADIV RASQQEAERI IRELRRMQKE 610 620 630 640 650 660 KQAEIKEHEL IEAKKRLEEA IPTLEKKKKE RKKQTQHAFQ PGDEVKVTSL NQKGYLVEKV 670 680 690 700 710 720 SDDEWQVQLG ILKMKINERD LEYIGSAPKT ETKPLATVKG KDYHVGLELD LRGERYEDAI 730 740 750 760 770 780 VRLEKYIDDA LLAGYPRVSI IHGKGTGALR KGVQEFLKKH RSVKNFHFGE ANEGGTGVTI VELK

References

[1]

"Complete sequence of chromosome of Geopacillus sp. WCH70." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Brumm P., Mead D.A., Richardson P. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WCH70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001638 Genomic DNA. Translation: ACS25326.1.
RefSeq	YP_002950592.1. NC_012793.1.
3D structure databases
ProteinModelPortal	C5D5Q8.
ModBase	Search...
Protein-protein interaction databases
STRING	471223.GWCH70_2632.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACS25326; ACS25326; GWCH70_2632.
GeneID	7978295.
KEGG	gwc:GWCH70_2632.
PATRIC	21974330. VBIGeoSp101709_2766.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1193.
HOGENOM	HOG000135096.
KO	K07456.
OMA	HDQSSTG.
ProtClustDB	PRK00409.
Enzyme and pathway databases
BioCyc	GSP471223:GH2C-2761-MONOMER.
Family and domain databases
HAMAP	MF_00092. MutS2.
InterPro	IPR005747. DNA_mismatch_repair_MutS-2. IPR000432. DNA_mismatch_repair_MutS_C. IPR007696. DNA_mismatch_repair_MutS_core. IPR002625. Smr/MutS2_C. [Graphical view]
PANTHER	PTHR11361:SF14. PTHR11361:SF14. 1 hit.
Pfam	PF05192. MutS_III. 1 hit. PF00488. MutS_V. 1 hit. PF01713. Smr. 1 hit. [Graphical view]
PIRSF	PIRSF005814. MutS_YshD. 1 hit.
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. SM00463. SMR. 1 hit. [Graphical view]
SUPFAM	SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMs	TIGR01069. mutS2. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. PS50828. SMR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTS2_GEOSW

Accession

Primary (citable) accession number: C5D5Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program