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C5D5Q8 (MUTS2_GEOSW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endonuclease MutS2

EC=3.1.-.-
Gene names
Name:mutS2
Ordered Locus Names:GWCH70_2632
OrganismGeobacillus sp. (strain WCH70) [Complete proteome] [HAMAP]
Taxonomic identifier471223 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length784 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity By similarity. HAMAP-Rule MF_00092

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00092

Sequence similarities

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.

Contains 1 Smr domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 784784Endonuclease MutS2 HAMAP-Rule MF_00092
PRO_1000202682

Regions

Domain709 – 78476Smr
Nucleotide binding335 – 3428ATP Potential

Sequences

Sequence LengthMass (Da)Tools
C5D5Q8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 1591E98610B9C536

FASTA78488,538
        10         20         30         40         50         60 
MHTRVLHVLE FDKVKEQLLE HVSSSLGKEK VEKLFPSSHF AEVTNWQEET DEAVAALRLR 

        70         80         90        100        110        120 
GHVPLGGIFD IRASLKRAKI GGTLSPHELL DIASTISASR QLKQFIESLH EEKEEFPHLA 

       130        140        150        160        170        180 
GYAEKLAALP EVQQAIERCI DDHGEVMDHA SERLRSIRQQ LRTTEARVRE KLENIIRSQS 

       190        200        210        220        230        240 
AQKMLSDAII TIRNDRYVIP VKQEYRGVYG GIVHDQSASG ATLFIEPQAV VELNNQLQEA 

       250        260        270        280        290        300 
RVKEKREIER ILTELTSIVA EHAEALLENV DILAQLDFIF AKAKYANKLK ATKPVMNDRG 

       310        320        330        340        350        360 
YIRLLQARHP LIDQDVVVPN DIELGKDYTT IVITGPNTGG KTVTLKTIGL LTLMAQAGLF 

       370        380        390        400        410        420 
IPALDGSELA VFRSVYADIG DEQSIEQSLS TFSSHMVNIV DILRNVDHES LVLFDELGAG 

       430        440        450        460        470        480 
TDPQEGAALA IAILDEVHGR GARTVATTHY PELKAYGYNR DGVINASVEF DTETLRPTYK 

       490        500        510        520        530        540 
LLIGIPGRSN AFEISKRLGL DERIIERAKS HISAESNKVE NMIASLEQSK KRAEEEEKKA 

       550        560        570        580        590        600 
KEARMEAEKL RSDWEQKWEE LHEKRDEIIE EAKRKAADIV RASQQEAERI IRELRRMQKE 

       610        620        630        640        650        660 
KQAEIKEHEL IEAKKRLEEA IPTLEKKKKE RKKQTQHAFQ PGDEVKVTSL NQKGYLVEKV 

       670        680        690        700        710        720 
SDDEWQVQLG ILKMKINERD LEYIGSAPKT ETKPLATVKG KDYHVGLELD LRGERYEDAI 

       730        740        750        760        770        780 
VRLEKYIDDA LLAGYPRVSI IHGKGTGALR KGVQEFLKKH RSVKNFHFGE ANEGGTGVTI 


VELK 

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References

[1]"Complete sequence of chromosome of Geopacillus sp. WCH70."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Brumm P., Mead D.A., Richardson P.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WCH70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001638 Genomic DNA. Translation: ACS25326.1.
RefSeqYP_002950592.1. NC_012793.1.

3D structure databases

ProteinModelPortalC5D5Q8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471223.GWCH70_2632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS25326; ACS25326; GWCH70_2632.
GeneID7978295.
KEGGgwc:GWCH70_2632.
PATRIC21974330. VBIGeoSp101709_2766.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1193.
HOGENOMHOG000135096.
KOK07456.
OMAHDQSSTG.
OrthoDBEOG6P5ZC4.
ProtClustDBPRK00409.

Enzyme and pathway databases

BioCycGSP471223:GH2C-2728-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00092. MutS2.
InterProIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFPIRSF005814. MutS_YshD. 1 hit.
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01069. mutS2. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS2_GEOSW
AccessionPrimary (citable) accession number: C5D5Q8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families