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C5D5M0

- LEU1_GEOSW

UniProt

C5D5M0 - LEU1_GEOSW

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Protein
2-isopropylmalate synthase
Gene
leuA, GWCH70_2593
Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-isopropylmalate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesis

Enzyme and pathway databases

BioCyciGSP471223:GH2C-2688-MONOMER.
UniPathwayiUPA00048; UER00070.

Names & Taxonomyi

Protein namesi
Recommended name:
2-isopropylmalate synthase (EC:2.3.3.13)
Alternative name(s):
Alpha-IPM synthase
Alpha-isopropylmalate synthase
Gene namesi
Name:leuA
Ordered Locus Names:GWCH70_2593
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5155152-isopropylmalate synthaseUniRule annotation
PRO_1000213314Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi471223.GWCH70_2593.

Structurei

3D structure databases

ProteinModelPortaliC5D5M0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0119.
HOGENOMiHOG000046859.
KOiK01649.
OMAiRKINIFD.
OrthoDBiEOG6CGCF3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01025. LeuA_type1.
InterProiIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTiSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF110921. SSF110921. 1 hit.
TIGRFAMsiTIGR00973. leuA_bact. 1 hit.
PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5D5M0-1 [UniParc]FASTAAdd to Basket

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MRKINIFDTT LRDGEQSAGI NLNLQEKLEI ARQLERLGVD IIEAGFPASS    50
KGDFQAVKQI AETIKTCSVT GLARSVQSDI DAAWEALKGG AEPRLHLFIA 100
TSPIHMKYKL QMTPEQVIET AVESVKYAKR YFPIVQWSAE DACRSELPFL 150
AKIITEVIKA GATVINIPDT VGYITPKEYG NIFTFLSNNV PNIEKVSLSA 200
HCHDDLGMAV ANSLAAIEHG ATQIEGTING IGERAGNAAL EEIAVALYIR 250
KDYYQAETRL NLQEIKRTSN LVSKLTGVVI PPNKAVIGKN AFAHESGIHQ 300
DGVLKEKTTY EIISPELVGV QSNSMVLGKH SGRHALRNRV EELGYTLSDE 350
EVNKLFVRFK ELADKKKDIT DDDLVALIFE EKFDHFKDFY QLSSLQVQYG 400
TNQIPTAVVV LKDGQGNEIQ EAATGAGSVE ALYNTLERCF KTSVTLLDYR 450
IESVSGGRDA LAQVFVKVRV NDIETSGRGT AQDVLEASAK AYINAVNRVF 500
MIETMRAENQ KVAMQ 515
Length:515
Mass (Da):56,758
Last modified:July 28, 2009 - v1
Checksum:iBD59459DE3FDC9BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25288.1.
RefSeqiWP_015864699.1. NC_012793.1.
YP_002950554.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS25288; ACS25288; GWCH70_2593.
GeneIDi7976353.
KEGGigwc:GWCH70_2593.
PATRICi21974248. VBIGeoSp101709_2726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS25288.1 .
RefSeqi WP_015864699.1. NC_012793.1.
YP_002950554.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D5M0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_2593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS25288 ; ACS25288 ; GWCH70_2593 .
GeneIDi 7976353.
KEGGi gwc:GWCH70_2593.
PATRICi 21974248. VBIGeoSp101709_2726.

Phylogenomic databases

eggNOGi COG0119.
HOGENOMi HOG000046859.
KOi K01649.
OMAi RKINIFD.
OrthoDBi EOG6CGCF3.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00070 .
BioCyci GSP471223:GH2C-2688-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01025. LeuA_type1.
InterProi IPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view ]
Pfami PF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view ]
SMARTi SM00917. LeuA_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF110921. SSF110921. 1 hit.
TIGRFAMsi TIGR00973. leuA_bact. 1 hit.
PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiLEU1_GEOSW
AccessioniPrimary (citable) accession number: C5D5M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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