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C5D4I2

- PUR5_GEOSW

UniProt

C5D4I2 - PUR5_GEOSW

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, GWCH70_0261
Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP471223:GH2C-320-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:GWCH70_0261
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000212824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_0261.

Structurei

3D structure databases

ProteinModelPortaliC5D4I2.
SMRiC5D4I2. Positions 17-342.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D4I2-1 [UniParc]FASTAAdd to Basket

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MAEAYKQAGV DIEAGYKAVS LMKQHVQKTM RPEVLSGLGG FGGMFDLSSL    50
GYREPVLISG TDGVGTKLKI AFMMDCHDTI GIDCVAMCVN DIVVQGAEPL 100
FFLDYIACGK AIPEKIAQIV KGIADGCVEA GCALIGGETA EMPGMYDENE 150
YDVAGFAVGI AEKSKLVTGS AIQAGDALIG LASNGIHSNG YSLVRRIVFE 200
QAKLALDRVY EPLSVPLGEE LLKPTRIYVK PLLNVMKQFE IKGMAHITGG 250
GFIENIPRML PKGLGAEIDY GSWPIPPVFD LLQEKGNLLR HDMFSIFNMG 300
IGMVLAVDSE MIHPVIARLE ELGEKAYLIG RVKQGEGVSF AGGAMS 346
Length:346
Mass (Da):37,040
Last modified:July 28, 2009 - v1
Checksum:i4EB71C3520487DCD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS23190.1.
RefSeqiWP_012749007.1. NC_012793.1.
YP_002948456.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS23190; ACS23190; GWCH70_0261.
GeneIDi7976127.
KEGGigwc:GWCH70_0261.
PATRICi21969305. VBIGeoSp101709_0296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS23190.1 .
RefSeqi WP_012749007.1. NC_012793.1.
YP_002948456.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D4I2.
SMRi C5D4I2. Positions 17-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_0261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS23190 ; ACS23190 ; GWCH70_0261 .
GeneIDi 7976127.
KEGGi gwc:GWCH70_0261.
PATRICi 21969305. VBIGeoSp101709_0296.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci GSP471223:GH2C-320-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiPUR5_GEOSW
AccessioniPrimary (citable) accession number: C5D4I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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