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C5D4D3

- C5D4D3_GEOSW

UniProt

C5D4D3 - C5D4D3_GEOSW

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Protein

Alanine racemase

Gene

GWCH70_0210

Organism
Geobacillus sp. (strain WCH70)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei137 – 1371SubstrateUniRule annotation
Active sitei266 – 2661Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei313 – 3131Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGSP471223:GH2C-251-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:GWCH70_0210Imported
OrganismiGeobacillus sp. (strain WCH70)Imported
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_0210.

Structurei

3D structure databases

ProteinModelPortaliC5D4D3.
SMRiC5D4D3. Positions 3-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiIYSHLAL.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5D4D3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNLFYRDTW AEIDLDAIYY NVSQLKNFLQ NDIRIMAVVK ANAYGHGDVQ
60 70 80 90 100
VAKTALEAGA SYLAVAFLDE AIALRKKGVT APILVLGACR PSDINIAAKH
110 120 130 140 150
RITLTVFQPE WIEQAANVYS ETSPVLFHLK MDTGMGRLGV REETETKRVI
160 170 180 190 200
EQIDRHPYFS LEGAYTHFAT ADEINTDYFS FQYDNFLRML EWLPYKPPII
210 220 230 240 250
HCGNSATALR FPDKAFNMVR FGISMYGLSP SPEIKQYLPY ELKEAFSLHS
260 270 280 290 300
RLVHVKKLKP GEKVSYGATY TAETEQWVGT VPIGYADGWL RKLQNFHVLV
310 320 330 340 350
NGEKAPIIGR ICMDQLMVRL PKQMPVGTKV TLIGRQGDEY ISVDDVAQYL
360 370 380
GTINYEVPCT ISYRVPRIFF RNKSIMEVRN FVLDGND
Length:387
Mass (Da):43,964
Last modified:July 28, 2009 - v1
Checksum:i66637A3B6A4C9966
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS23141.1.
RefSeqiWP_012748964.1. NC_012793.1.
YP_002948407.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS23141; ACS23141; GWCH70_0210.
GeneIDi7977953.
KEGGigwc:GWCH70_0210.
PATRICi21969157. VBIGeoSp101709_0240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS23141.1 .
RefSeqi WP_012748964.1. NC_012793.1.
YP_002948407.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D4D3.
SMRi C5D4D3. Positions 3-382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_0210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS23141 ; ACS23141 ; GWCH70_0210 .
GeneIDi 7977953.
KEGGi gwc:GWCH70_0210.
PATRICi 21969157. VBIGeoSp101709_0240.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi IYSHLAL.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci GSP471223:GH2C-251-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70Imported.

Entry informationi

Entry nameiC5D4D3_GEOSW
AccessioniPrimary (citable) accession number: C5D4D3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3