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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:GWCH70_0199
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000002386 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002020231 – 357UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST357

Interactioni

Protein-protein interaction databases

STRINGi471223.GWCH70_0199.

Structurei

3D structure databases

ProteinModelPortaliC5D4C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218322.
KOiK02563.
OMAiNSIFEFL.
OrthoDBiPOG091H02FX.

Family and domain databases

CDDicd03785. GT1_MurG. 1 hit.
HAMAPiMF_00033. MurG. 1 hit.
InterProiView protein in InterPro
IPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
PfamiView protein in Pfam
PF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D4C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKIILTGG GTAGHVMVNL ALIPKLKEQG WDIAYIGSHQ GIERELISKV
60 70 80 90 100
EGVPYFPIST GKLRRYFDWN NFKDPFKVLK GTFQAYRIIK KEKPSIVFSK
110 120 130 140 150
GGFVSVPVII GAWLNGVPSI IHESDITPGL ANKIAMPFAT KICVTFPETL
160 170 180 190 200
RHVKEEKGIY IGAVVREELK RGNADKGRTL CQFEKGKPVL LVMGGSLGSK
210 220 230 240 250
RINDALRANL QTLLDDFQIV HICGKGNVDP QWTNKKGYKQ FEYVHEELPH
260 270 280 290 300
LMAMADIVLS RAGANSIFEF LALRKPMLLI PLSKEASRGD QILNARSFEK
310 320 330 340 350
SGYAEVLMEE NLTNESLRNA IYHLYQNKDR YRQNMDRSDA GDALQKLLTL

IEEARKS
Length:357
Mass (Da):40,119
Last modified:July 28, 2009 - v1
Checksum:iB274061D5B8474F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001638 Genomic DNA. Translation: ACS23130.1.
RefSeqiWP_012748953.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS23130; ACS23130; GWCH70_0199.
KEGGigwc:GWCH70_0199.

Similar proteinsi

Entry informationi

Entry nameiMURG_GEOSW
AccessioniPrimary (citable) accession number: C5D4C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: August 30, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families