C5D3Y4UPPP_GEOSWUndecaprenyl-diphosphatase3.6.1.27Bacitracin resistance proteinUndecaprenyl pyrophosphate phosphataseuppPGWCH70_0186Geobacillus sp. (strain WCH70)BacteriaBacillotaBacilliBacillalesBacillaceaeGeobacillusComplete sequence of chromosome of Geopacillus sp. WCH70.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphateCell membraneMulti-pass membrane proteinBacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.Belongs to the UppP family.Antibiotic resistanceCell membraneCell shapeCell wall biogenesis/degradationHydrolaseMembranePeptidoglycan synthesisTransmembraneTransmembrane helixMDIVEIIKAIILGMVEGLTEFAPVSSTGHMIIVDDMWLKSQEFLGKYAANTFKVVIQLGSILAVVVVFKDRFIDLLGLRGRHRDGKPRLKLMQVIVGLIPAGVLGVLFEDYIDEHLFSTATVLIGLVLGALLMIAADVFAKKAPKAQTVDQITYKQALIVGLVQCLSLWPGFSRSGSTISGGVLVGMSHRAAADFTFIMAVPIMMGASVLSLLKNWQYFTIDALPFFTAGFISAFLFALISIRFFLKLINQIRLVPFAVYRIVLALVIYIVYF
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