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C5D3E0 (AROB_GEOSW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:GWCH70_2145
OrganismGeobacillus sp. (strain WCH70) [Complete proteome] [HAMAP]
Taxonomic identifier471223 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3753753-dehydroquinate synthase HAMAP MF_00110
PRO_1000202911

Sequences

Sequence LengthMass (Da)Tools
C5D3E0 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: CD2DB11252562564

FASTA37542,365
        10         20         30         40         50         60 
MEQIVIETKT KQYPLFLGEG IIESLPDILR QLSFSKGTKL LIITDKTLEQ LYLSRLCALL 

        70         80         90        100        110        120 
ANDYDVYTYV IPSGEEAKSF EQYYACQTAA LQYGLDRKSL ILAFGGGVVG DLAGFVAATY 

       130        140        150        160        170        180 
MRGIPYIQIP TTLLAHDSAV GGKVAINHPL GKNMIGAFYQ PEAVVYDIAF LRSLPEKELR 

       190        200        210        220        230        240 
SGFAEVIKHA LIRDRDFYQW LRQEIRELAD LKGERLQYCI KKGIEVKASV VREDEKETGV 

       250        260        270        280        290        300 
RAHLNFGHTL GHALENELGY GAMTHGDAVA LGMLFAIFVS ERVYNISLDY DRFSSWFRTY 

       310        320        330        340        350        360 
GFPVSIPKQL NINRLLEKMK GDKKARAGTV RMVLLKDIGM AEIKPLDDET LLALLRKFQR 

       370 
EEGENDPRNS RCHYC

« Hide

References

[1]"Complete sequence of chromosome of Geopacillus sp. WCH70."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Brumm P., Mead D.A., Richardson P.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WCH70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001638 Genomic DNA. Translation: ACS24855.1.
RefSeqYP_002950121.1. NC_012793.1.

3D structure databases

ProteinModelPortalC5D3E0.
ModBaseSearch...

Protein-protein interaction databases

STRINGC5D3E0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7976955.
GenomeReviewsGene locus GWCH70_2145 in contig CP001638_GR.
KEGGgwc:GWCH70_2145.
PATRIC21973322. VBIGeoSp101709_2263.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAGTFTQPD.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_GEOSW
AccessionPrimary (citable) accession number: C5D3E0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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