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C5D2K6

- MASZ_GEOSW

UniProt

C5D2K6 - MASZ_GEOSW

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Protein
Malate synthase G
Gene
glcB, GWCH70_1913
Organism
Geobacillus sp. (strain WCH70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei275 – 2751Acetyl-CoA By similarity
Binding sitei312 – 3121Acetyl-CoA By similarity
Active sitei339 – 3391Proton acceptor By similarity
Binding sitei339 – 3391Glyoxylate By similarity
Metal bindingi431 – 4311Magnesium By similarity
Binding sitei431 – 4311Glyoxylate By similarity
Metal bindingi459 – 4591Magnesium By similarity
Binding sitei540 – 5401Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei630 – 6301Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciGSP471223:GH2C-1998-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:GWCH70_1913
OrganismiGeobacillus sp. (strain WCH70)
Taxonomic identifieri471223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000002386: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Malate synthase GUniRule annotation
PRO_1000212376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei616 – 6161Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi471223.GWCH70_1913.

Structurei

3D structure databases

ProteinModelPortaliC5D2K6.
SMRiC5D2K6. Positions 5-723.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252Acetyl-CoA binding By similarity
Regioni456 – 4594Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

C5D2K6-1 [UniParc]FASTAAdd to Basket

« Hide

MGEYVKVGNL QVAKLFYEFM NDEVLPGSEV NKEKFWKDFE TLIADLTPKN    50
KALLARRDEL QAKINEWHKE HRGNFDMEKY KAFLTDIGYL EPEVDDFEIT 100
TEGVDEEIAV QAGPQLVVPL TNARYALNAA NARWGSLYDA LYGTDAISEE 150
DGAERGDSYN PVRGAKVIAY AREFLDQAVP LKEYSHKDAV QYAVVDGKLV 200
VSVEGGSTTT LKEEEKFIGF QGNPENPTAI LLKNNGLHIE IQIDRNHPVG 250
KTDKAGVKDI YLEAAVTTIM DGEDSVAAVD AEDKVLVYRN LLGLVKGDLT 300
STFTKGGKTI TRALNPDRVY RTADGKEITL PGRSLMFVRN VGHLMTNNTI 350
LDANGEEVYE GIMDAVVTSL IMKHSLLGNT RYLNSRKGSF YIVKPKMHGS 400
EEVAFANELF DRVEDMLGLK RNTIKIGVMD EERRTTLNLK NCIYQVRDRI 450
IFINTGFLDR TGDEIHTSME AGPMIRKNDM KTSVWLQAYE KSNVTIGLAA 500
GFQGRAQIGK GMWAMPDMMA EMLKQKGGQL KAGANTAWVP SPTAATLHAL 550
HYHQVNVAEV QNELRKERKD YRDEILQIPV AVNPQWTPEE IQEELDNNCQ 600
GILGYVVRWI DQGIGCSKVP DINNIGLMED RATLRISSQH IANWLHHGIC 650
TKEQVLETLK RMAKVVDEQN AGDPNYRPMA PDYDNSVAFQ AACDLIFKGY 700
EQPNGYTEPI LHRRRLEAKA KYAAVQQ 727
Length:727
Mass (Da):81,560
Last modified:July 28, 2009 - v1
Checksum:i388CE77A1DDDCE1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS24648.1.
RefSeqiWP_015864085.1. NC_012793.1.
YP_002949914.1. NC_012793.1.

Genome annotation databases

EnsemblBacteriaiACS24648; ACS24648; GWCH70_1913.
GeneIDi7978740.
KEGGigwc:GWCH70_1913.
PATRICi21972822. VBIGeoSp101709_2022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001638 Genomic DNA. Translation: ACS24648.1 .
RefSeqi WP_015864085.1. NC_012793.1.
YP_002949914.1. NC_012793.1.

3D structure databases

ProteinModelPortali C5D2K6.
SMRi C5D2K6. Positions 5-723.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471223.GWCH70_1913.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS24648 ; ACS24648 ; GWCH70_1913 .
GeneIDi 7978740.
KEGGi gwc:GWCH70_1913.
PATRICi 21972822. VBIGeoSp101709_2022.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci GSP471223:GH2C-1998-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WCH70.

Entry informationi

Entry nameiMASZ_GEOSW
AccessioniPrimary (citable) accession number: C5D2K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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